{ "version": "VBASE3-2026.09", "title": "VBASE3 Pan-Vertebrate Constant Region Database with GenBank Traceability", "description": "Modular constant region cassettes (Secreted and Alternative-Spliced Membrane forms) linked directly to original GenBank/EMBL flat files with 5' sequence tags for single-cell read mapping", "total_entries": 108, "records": [ { "id": "VBASE3_C_HUMAN_IGHM_SEC_01", "genbank_accession": "M21624", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M21624", "genbank_record_file": "data/constant_regions/genbank_records/M21624.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHM", "allele": "01", "allotype": "Native", "isotype": "IgM", "class": "IgM", "form": "Secreted", "full_length": 453, "full_sequence": "GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY", "ch1_sequence": "GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPV", "hinge_sequence": "", "ch2_sequence": "VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVP", "ch3_sequence": "DQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPK", "ch4_sequence": "GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG", "tailpiece_sequence": "KPTLYNVSLVMSDTAGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 348, "fc_sequence": "VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "GSASAPTLFPLVSCE", "tag_5p_aa_30": "GSASAPTLFPLVSCENSPSDTSSVAVGCLA", "diagnostic_motif": "N-terminal GSASAPTLFPLVSCE distinguishes IgM from all other isotypes; tailpiece contains Cys575 for J-chain incorporation.", "genomic_locus_order": "IGH: 1/9 (Cmu)", "genbank_definition": "Human immunoglobulin heavy chain constant region mu gene, complete cds.", "description": "Human immunoglobulin heavy chain constant region mu gene, complete cds.", "notes": "Secreted pentameric/hexameric IgM backbone. Includes tailpiece C-terminal cysteine (Cys575) essential for J-chain covalent linkage." }, { "id": "VBASE3_C_HUMAN_IGHM_MEM_01", "genbank_accession": "X14939", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/X14939", "genbank_record_file": "data/constant_regions/genbank_records/X14939.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHM", "allele": "01", "allotype": "Native", "isotype": "IgM", "class": "IgM", "form": "Membrane", "full_length": 475, "full_sequence": "GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK", "ch1_sequence": "GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPV", "hinge_sequence": "", "ch2_sequence": "VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVP", "ch3_sequence": "DQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPK", "ch4_sequence": "GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG", "tailpiece_sequence": "", "m1_sequence": "EGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "EGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK", "fc_length": 329, "fc_sequence": "VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "GSASAPTLFPLVSCE", "tag_5p_aa_30": "GSASAPTLFPLVSCENSPSDTSSVAVGCLA", "diagnostic_motif": "Alternative splicing after CH4 residue 555 joins to M1/M2 exons; short KVK cytoplasmic tail interacts with CD79a/CD79b (Igalpha/Igbeta).", "genomic_locus_order": "IGH: 1/9 (Cmu)", "genbank_definition": "Homo sapiens mRNA for membrane-bound immunoglobulin mu chain.", "description": "Homo sapiens mRNA for membrane-bound immunoglobulin mu chain.", "notes": "Membrane-bound B-cell receptor (BCR) IgM monomer. Forms functional BCR signaling complex non-covalently coupled to CD79a/CD79b heterodimers." }, { "id": "VBASE3_C_HUMAN_IGHD_SEC_01", "genbank_accession": "K02875", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/K02875", "genbank_record_file": "data/constant_regions/genbank_records/K02875.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHD", "allele": "01", "allotype": "Native", "isotype": "IgD", "class": "IgD", "form": "Secreted", "full_length": 384, "full_sequence": "APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK", "ch1_sequence": "APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWP", "hinge_sequence": "ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECP", "ch2_sequence": "SHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPA", "ch3_sequence": "AQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS", "ch4_sequence": "", "tailpiece_sequence": "YVTDHGPMK", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 283, "fc_sequence": "ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "APTKAPDVFPIISGC", "tag_5p_aa_30": "APTKAPDVFPIISGCRHPKDNSPVVLACLI", "diagnostic_motif": "N-terminal APTKAPDVFPIISGC; elongated 64-aa highly flexible hinge; 9-aa secretory tailpiece.", "genomic_locus_order": "IGH: 2/9 (Cdelta)", "genbank_definition": "Human germline IgD chain gene, C-region, complete cds.", "description": "Human germline IgD chain gene, C-region, complete cds.", "notes": "Secreted serum IgD. Produced in trace amounts by alternative polyadenylation without class switch recombination." }, { "id": "VBASE3_C_HUMAN_IGHD_MEM_01", "genbank_accession": "BC063384", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BC063384", "genbank_record_file": "data/constant_regions/genbank_records/BC063384.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHD", "allele": "01", "allotype": "Native", "isotype": "IgD", "class": "IgD", "form": "Membrane", "full_length": 430, "full_sequence": "APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK", "ch1_sequence": "APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWP", "hinge_sequence": "ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECP", "ch2_sequence": "SHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPA", "ch3_sequence": "AQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "YLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIK", "m2_sequence": "VK", "membrane_anchor_sequence": "YLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK", "fc_length": 274, "fc_sequence": "ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "APTKAPDVFPIISGC", "tag_5p_aa_30": "APTKAPDVFPIISGCRHPKDNSPVVLACLI", "diagnostic_motif": "Membrane M1/M2 exons spliced after CH3; co-expressed with mIgM on mature naive follicular B cells via alternative splicing.", "genomic_locus_order": "IGH: 2/9 (Cdelta)", "genbank_definition": "Homo sapiens immunoglobulin heavy constant delta, mRNA (cDNA clone MGC:75200 IMAGE:6549048), complete cds.", "description": "Homo sapiens immunoglobulin heavy constant delta, mRNA (cDNA clone MGC:75200 IMAGE:6549048), complete cds.", "notes": "Membrane-bound IgD BCR. Co-expressed alongside membrane IgM on naive mature B cells through differential pre-mRNA cleavage and splicing." }, { "id": "VBASE3_C_HUMAN_IGHG1_SEC_01", "genbank_accession": "J00228", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00228", "genbank_record_file": "data/constant_regions/genbank_records/J00228.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG1", "allele": "01", "allotype": "G1m17,1", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 330, "full_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch1_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV", "hinge_sequence": "EPKSCDKTHTCPPCP", "ch2_sequence": "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 232, "fc_sequence": "EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPSS", "tag_5p_aa_30": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVK", "diagnostic_motif": "CH1 residue 14 (Ser) distinguishes IgG1 from IgG2/3/4 (which have Cys14); residue 18 (Gly) distinguishes IgG1/3 from IgG2/4 (Ser18).", "genomic_locus_order": "IGH: 4/9 (Cgamma1)", "genbank_definition": "Homo sapiens immunoglobulin gamma-1 heavy chain constant region (IGHG1) gene, partial cds.", "description": "Homo sapiens immunoglobulin gamma-1 heavy chain constant region (IGHG1) gene, partial cds.", "notes": "Canonical human IgG1 backbone. Backbone of Trastuzumab, Rituximab, Adalimumab. Potent ADCC and C1q complement activation." }, { "id": "VBASE3_C_HUMAN_IGHG1_MEM_01", "genbank_accession": "X52847", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/X52847", "genbank_record_file": "data/constant_regions/genbank_records/X52847.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG1", "allele": "01", "allotype": "G1m17,1", "isotype": "IgG1", "class": "IgG", "form": "Membrane", "full_length": 400, "full_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "ch1_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV", "hinge_sequence": "EPKSCDKTHTCPPCP", "ch2_sequence": "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK", "m2_sequence": "VKWIFSSVVDLKQTIIPDYRNMIGQGA", "membrane_anchor_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "fc_length": 231, "fc_sequence": "EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPSS", "tag_5p_aa_30": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVK", "diagnostic_motif": "Spliced after CH3 residue 445 (SPG); M1 contains 18-aa extracellular spacer + 26-aa TM domain; M2 has 27-aa cytoplasmic signaling tail.", "genomic_locus_order": "IGH: 4/9 (Cgamma1)", "genbank_definition": "Human mRNA for membrane-bound immunoglobulin gamma-1 chain.", "description": "Human mRNA for membrane-bound immunoglobulin gamma-1 chain.", "notes": "Membrane-bound IgG1 BCR. Expressed on memory B cells and plasmablasts following class switch recombination." }, { "id": "VBASE3_C_HUMAN_IGHG1_LALA", "genbank_accession": "J00228", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00228", "genbank_record_file": "data/constant_regions/genbank_records/J00228.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG1", "allele": "LALA-PG", "allotype": "Effector-Silent", "isotype": "IgG1", "class": "IgG", "form": "Engineered", "full_length": 330, "full_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch1_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV", "hinge_sequence": "EPKSCDKTHTCPPCP", "ch2_sequence": "APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 232, "fc_sequence": "EPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPSS", "tag_5p_aa_30": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVK", "diagnostic_motif": "Engineered triple mutation: L234A, L235A, and P329G in CH2 completely ablate Fc-gamma receptor and C1q binding.", "genomic_locus_order": "Engineered variant (derived from GenBank J00228 Cgamma1)", "genbank_definition": "Engineered derivative of GenBank J00228 with L234A, L235A, P329G mutations.", "description": "Engineered derivative of GenBank J00228 with L234A, L235A, P329G mutations.", "notes": "Engineered effector-silent Fc standard. Eliminates ADCC, ADCP, and CDC for receptor-blocking therapeutics." }, { "id": "VBASE3_C_HUMAN_IGHG2_SEC_01", "genbank_accession": "J00230", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00230", "genbank_record_file": "data/constant_regions/genbank_records/J00230.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG2", "allele": "01", "allotype": "G2m(..)", "isotype": "IgG2", "class": "IgG", "form": "Secreted", "full_length": 326, "full_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTV", "hinge_sequence": "ERKCCVECPPCP", "ch2_sequence": "APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK", "ch3_sequence": "GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 228, "fc_sequence": "ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSESTAALGCLVK", "diagnostic_motif": "CH1 residue 14 (Cys) + residue 18 (Ser); rigid 4-cysteine hinge (ERKCCVECPPCP) forming disulfide isomers A and B.", "genomic_locus_order": "IGH: 6/9 (Cgamma2)", "genbank_definition": "Human Ig germline H-chain G-E-A region B: gamma-2 constant region, 3' end.", "description": "Human Ig germline H-chain G-E-A region B: gamma-2 constant region, 3' end.", "notes": "Secreted IgG2 backbone. Specialized for carbohydrate and bacterial polysaccharide antigens. Panitumumab and Denosumab backbone." }, { "id": "VBASE3_C_HUMAN_IGHG2_MEM_01", "genbank_accession": "AB006775", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AB006775", "genbank_record_file": "data/constant_regions/genbank_records/AB006775.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG2", "allele": "01", "allotype": "G2m(..)", "isotype": "IgG2", "class": "IgG", "form": "Membrane", "full_length": 396, "full_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTV", "hinge_sequence": "ERKCCVECPPCP", "ch2_sequence": "APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK", "ch3_sequence": "GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFK", "m2_sequence": "VKWIFSSVVDLKQTIVPDYRNMIRQGA", "membrane_anchor_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA", "fc_length": 227, "fc_sequence": "ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSESTAALGCLVK", "diagnostic_motif": "M1 position 40 carries Ile (ATITFFK) vs Val in IgG1/3 (ATVTFFK); M2 position 23 carries Arg (MIRQGA) vs Gly in IgG1/3 (MIGQGA).", "genomic_locus_order": "IGH: 6/9 (Cgamma2)", "genbank_definition": "Homo sapiens gene for membrane-bound form of IgG2 heavy chain, complete cds.", "description": "Homo sapiens gene for membrane-bound form of IgG2 heavy chain, complete cds.", "notes": "Membrane-bound IgG2 BCR. Expressed on memory B cells responsive to encapsulated bacterial antigens." }, { "id": "VBASE3_C_HUMAN_IGHG3_SEC_01", "genbank_accession": "M12886", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M12886", "genbank_record_file": "data/constant_regions/genbank_records/M12886.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG3", "allele": "01", "allotype": "G3m(g)", "isotype": "IgG3", "class": "IgG", "form": "Secreted", "full_length": 377, "full_sequence": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRV", "hinge_sequence": "ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCP", "ch2_sequence": "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTK", "ch3_sequence": "GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 279, "fc_sequence": "ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVK", "diagnostic_motif": "62-amino acid elongated poly-proline hinge (11 interchain disulfides); strongest C1q binding and effector potency among all human IgG subclasses.", "genomic_locus_order": "IGH: 3/9 (Cgamma3)", "genbank_definition": "Homo sapiens immunoglobulin heavy chain constant region gamma 3 gene, complete cds.", "description": "Homo sapiens immunoglobulin heavy chain constant region gamma 3 gene, complete cds.", "notes": "Secreted IgG3 backbone. Highly flexible elongated hinge provides superior neutralization of viruses but shorter serum half-life (7 days)." }, { "id": "VBASE3_C_HUMAN_IGHG3_MEM_01", "genbank_accession": "D78345", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/D78345", "genbank_record_file": "data/constant_regions/genbank_records/D78345.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG3", "allele": "01", "allotype": "G3m(g)", "isotype": "IgG3", "class": "IgG", "form": "Membrane", "full_length": 447, "full_sequence": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRV", "hinge_sequence": "ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCP", "ch2_sequence": "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTK", "ch3_sequence": "GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPG", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK", "m2_sequence": "VKWIFSSVVDLKQTIIPDYRNMIGQGA", "membrane_anchor_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "fc_length": 278, "fc_sequence": "ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSGGTAALGCLVK", "diagnostic_motif": "Combines 62-aa extended hinge with transmembrane M1 and cytoplasmic M2 exons.", "genomic_locus_order": "IGH: 3/9 (Cgamma3)", "genbank_definition": "Human mRNA for membrane-bound immunoglobulin gamma-3 chain.", "description": "Human mRNA for membrane-bound immunoglobulin gamma-3 chain.", "notes": "Membrane-bound IgG3 BCR. Participates in early antiviral B-cell memory." }, { "id": "VBASE3_C_HUMAN_IGHG4_SEC_01", "genbank_accession": "K01316", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/K01316", "genbank_record_file": "data/constant_regions/genbank_records/K01316.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG4", "allele": "01", "allotype": "G4m(a)", "isotype": "IgG4", "class": "IgG", "form": "Secreted", "full_length": 327, "full_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV", "hinge_sequence": "ESKYGPPCPSCP", "ch2_sequence": "APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 229, "fc_sequence": "ESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSESTAALGCLVK", "diagnostic_motif": "Labile CPSCP core hinge disulfides enable in vivo Fab-arm exchange; poor C1q and Fc-gamma receptor activation.", "genomic_locus_order": "IGH: 7/9 (Cgamma4)", "genbank_definition": "Human immunoglobulin heavy chain gamma 4 constant region gene, complete cds.", "description": "Human immunoglobulin heavy chain gamma 4 constant region gene, complete cds.", "notes": "Wild-type human IgG4 backbone. Undergoes half-antibody exchange in vivo creating bispecific antibodies." }, { "id": "VBASE3_C_HUMAN_IGHG4_MEM_01", "genbank_accession": "AL928742", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AL928742", "genbank_record_file": "data/constant_regions/genbank_records/AL928742.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG4", "allele": "01", "allotype": "G4m(a)", "isotype": "IgG4", "class": "IgG", "form": "Membrane", "full_length": 397, "full_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV", "hinge_sequence": "ESKYGPPCPSCP", "ch2_sequence": "APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK", "m2_sequence": "VKWIFSSVVDLKQTIVPDYRNMIRQGA", "membrane_anchor_sequence": "ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA", "fc_length": 228, "fc_sequence": "ESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSESTAALGCLVK", "diagnostic_motif": "Membrane form of IgG4 BCR; M1 spliced after CH3 SLG.", "genomic_locus_order": "IGH: 7/9 (Cgamma4)", "genbank_definition": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHG4 locus).", "description": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHG4 locus).", "notes": "Membrane-bound IgG4 BCR. Expressed on allergen-tolerant and Th2-skewed memory B cells." }, { "id": "VBASE3_C_HUMAN_IGHG4_S228P", "genbank_accession": "K01316", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/K01316", "genbank_record_file": "data/constant_regions/genbank_records/K01316.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHG4", "allele": "S228P", "allotype": "Engineered", "isotype": "IgG4", "class": "IgG", "form": "Engineered", "full_length": 327, "full_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "ch1_sequence": "ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV", "hinge_sequence": "ESKYGPPCPPCP", "ch2_sequence": "APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 229, "fc_sequence": "ESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTKGPSVFPLAPCS", "tag_5p_aa_30": "ASTKGPSVFPLAPCSRSTSESTAALGCLVK", "diagnostic_motif": "S228P core hinge mutation (CPPC) prevents intra-chain disulfide isomerism and abolishes in vivo Fab-arm exchange.", "genomic_locus_order": "Engineered variant (derived from GenBank K01316 Cgamma4)", "genbank_definition": "Engineered derivative of GenBank K01316 with S228P core hinge stabilizing mutation.", "description": "Engineered derivative of GenBank K01316 with S228P core hinge stabilizing mutation.", "notes": "Engineered IgG4 therapeutic standard. Backbone of Pembrolizumab (Keytruda) and Nivolumab (Opdivo)." }, { "id": "VBASE3_C_HUMAN_IGHA1_SEC_01", "genbank_accession": "J00220", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00220", "genbank_record_file": "data/constant_regions/genbank_records/J00220.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHA1", "allele": "01", "allotype": "Native", "isotype": "IgA1", "class": "IgA", "form": "Secreted", "full_length": 353, "full_sequence": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY", "ch1_sequence": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPV", "hinge_sequence": "PSTPPTPSPSTPPTPSPSC", "ch2_sequence": "CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS", "ch3_sequence": "GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK", "ch4_sequence": "", "tailpiece_sequence": "PTHVNVSVVMAEVDGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 250, "fc_sequence": "PSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASPTSPKVFPLSLCS", "tag_5p_aa_30": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQG", "diagnostic_motif": "N-terminal ASPTSPKVFPLSLC; 19-aa O-glycosylated hinge (PSTPPTPSPSTPPTPSPSC) sensitive to bacterial IgA1 proteases; 18-aa secretory tailpiece.", "genomic_locus_order": "IGH: 5/9 (Calpha1)", "genbank_definition": "Homo sapiens immunoglobulin alpha-1 heavy chain constant region (IGHA1) gene.", "description": "Homo sapiens immunoglobulin alpha-1 heavy chain constant region (IGHA1) gene.", "notes": "Secreted IgA1 monomer (serum) and dimer (mucosa). Tailpiece C-terminal cysteine forms disulfide bonds to J-chain." }, { "id": "VBASE3_C_HUMAN_IGHA1_MEM_01", "genbank_accession": "AL928742", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AL928742", "genbank_record_file": "data/constant_regions/genbank_records/AL928742.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHA1", "allele": "01", "allotype": "Native", "isotype": "IgA1", "class": "IgA", "form": "Membrane", "full_length": 405, "full_sequence": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKSCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY", "ch1_sequence": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPV", "hinge_sequence": "PSTPPTPSPSTPPTPSPSC", "ch2_sequence": "CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS", "ch3_sequence": "GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "SCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSV", "m2_sequence": "RGPSGNREGPQY", "membrane_anchor_sequence": "SCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY", "fc_length": 232, "fc_sequence": "PSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASPTSPKVFPLSLCS", "tag_5p_aa_30": "ASPTSPKVFPLSLCSTQPDGNVVIACLVQG", "diagnostic_motif": "M1 contains 58-aa extracellular stalk and TM domain; M2 contains 12-aa cytoplasmic tail with RGPSGN motif.", "genomic_locus_order": "IGH: 5/9 (Calpha1)", "genbank_definition": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA1 locus).", "description": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA1 locus).", "notes": "Membrane-bound IgA1 BCR. Expressed on mucosal-homing B cells and Peyer's patch germinal center B cells." }, { "id": "VBASE3_C_HUMAN_IGHA2_SEC_01", "genbank_accession": "J00221", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00221", "genbank_record_file": "data/constant_regions/genbank_records/J00221.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHA2", "allele": "01", "allotype": "A2m(1)", "isotype": "IgA2", "class": "IgA", "form": "Secreted", "full_length": 340, "full_sequence": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKPTHINVSVVMAEADGTCY", "ch1_sequence": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPV", "hinge_sequence": "PPPPPC", "ch2_sequence": "CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKS", "ch3_sequence": "GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK", "ch4_sequence": "", "tailpiece_sequence": "PTHINVSVVMAEADGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 237, "fc_sequence": "PPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKPTHINVSVVMAEADGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASPSVPKVFPLSLDS", "tag_5p_aa_30": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQG", "diagnostic_motif": "N-terminal ASPSVPKVFPLSLD (differs from IgA1 at positions 4, 5, 8, 9, 10); short 6-aa hinge lacking O-glycosylation is resistant to bacterial IgA1 proteases.", "genomic_locus_order": "IGH: 9/9 (Calpha2)", "genbank_definition": "Human Ig germline H-chain G-E-A region B: alpha-2 A2m(1) allele constant region.", "description": "Human Ig germline H-chain G-E-A region B: alpha-2 A2m(1) allele constant region.", "notes": "Secreted IgA2. Dominant secretory immunoglobulin in the distal gut and mucosal surfaces colonized by bacteria." }, { "id": "VBASE3_C_HUMAN_IGHA2_MEM_01", "genbank_accession": "AL928742", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AL928742", "genbank_record_file": "data/constant_regions/genbank_records/AL928742.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHA2", "allele": "01", "allotype": "A2m(1)", "isotype": "IgA2", "class": "IgA", "form": "Membrane", "full_length": 392, "full_sequence": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKSCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY", "ch1_sequence": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPV", "hinge_sequence": "PPPPPC", "ch2_sequence": "CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKS", "ch3_sequence": "GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "SCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSV", "m2_sequence": "RGPSGKREGPQY", "membrane_anchor_sequence": "SCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY", "fc_length": 219, "fc_sequence": "PPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASPSVPKVFPLSLDS", "tag_5p_aa_30": "ASPSVPKVFPLSLDSTPQDGNVVVACLVQG", "diagnostic_motif": "M1 carries N-terminal SCC (vs SCS in IgA1); M2 has RGPSGK motif (vs RGPSGN in IgA1).", "genomic_locus_order": "IGH: 9/9 (Calpha2)", "genbank_definition": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA2 locus).", "description": "Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA2 locus).", "notes": "Membrane-bound IgA2 BCR. Expressed on gut-associated lymphoid tissue B cells." }, { "id": "VBASE3_C_HUMAN_IGHE_SEC_01", "genbank_accession": "J00222", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00222", "genbank_record_file": "data/constant_regions/genbank_records/J00222.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHE", "allele": "01", "allotype": "Native", "isotype": "IgE", "class": "IgE", "form": "Secreted", "full_length": 428, "full_sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK", "ch1_sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFS", "hinge_sequence": "", "ch2_sequence": "VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA", "ch3_sequence": "DSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTS", "ch4_sequence": "GPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 325, "fc_sequence": "VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTQSPSVFPLTRCC", "tag_5p_aa_30": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCL", "diagnostic_motif": "Four constant domains (CH1-CH4) without hinge; CH2 serves as hinge equivalent; binds Fc-epsilon-RI with sub-nanomolar affinity.", "genomic_locus_order": "IGH: 8/9 (Cepsilon)", "genbank_definition": "Human Ig germline H-chain G-E-A region B: epsilon-1 C-region, 3' end.", "description": "Human Ig germline H-chain G-E-A region B: epsilon-1 C-region, 3' end.", "notes": "Secreted human IgE. Mediates antiparasitic immunity and allergic hypersensitivity. Target of omalizumab (Xolair)." }, { "id": "VBASE3_C_HUMAN_IGHE_MEM_01", "genbank_accession": "M55420", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M55420", "genbank_record_file": "data/constant_regions/genbank_records/M55420.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGH", "gene": "IGHE", "allele": "01", "allotype": "Native", "isotype": "IgE", "class": "IgE", "form": "Membrane", "full_length": 494, "full_sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLMVQRFLSATRQGRPQTSLDYTNVLQPHA", "ch1_sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFS", "hinge_sequence": "", "ch2_sequence": "VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA", "ch3_sequence": "DSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTS", "ch4_sequence": "GPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPG", "tailpiece_sequence": "", "m1_sequence": "LDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLM", "m2_sequence": "VQRFLSATRQGRPQTSLDYTNVLQPHA", "membrane_anchor_sequence": "LDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLMVQRFLSATRQGRPQTSLDYTNVLQPHA", "fc_length": 324, "fc_sequence": "VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTQSPSVFPLTRCC", "tag_5p_aa_30": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCL", "diagnostic_motif": "Membrane M1 carries LDVCVEE extracellular spacer + TM domain; M2 has 27-aa cytoplasmic tail.", "genomic_locus_order": "IGH: 8/9 (Cepsilon)", "genbank_definition": "Human immunoglobulin epsilon heavy chain membrane-bound form mRNA, complete cds.", "description": "Human immunoglobulin epsilon heavy chain membrane-bound form mRNA, complete cds.", "notes": "Membrane-bound IgE BCR. Regulates IgE commitment and allergic memory." }, { "id": "VBASE3_C_HUMAN_IGKC_01", "genbank_accession": "J00253", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00253", "genbank_record_file": "data/constant_regions/genbank_records/J00253.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGK", "gene": "IGKC", "allele": "01", "allotype": "Km(3)", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 107, "full_sequence": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "c_domain_sequence": "", "tag_5p_aa_15": "RTVAAPSVFIFPPSD", "tag_5p_aa_30": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLN", "diagnostic_motif": "N-terminal RTVAAPSVFIFPPSD; Km3 allotype carries Val153 and Leu191 (IMGT numbering); canonical C-terminal Cys forms interchain disulfide to heavy CH1.", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "Homo sapiens immunoglobulin kappa constant region (IGKC) gene.", "description": "Homo sapiens immunoglobulin kappa constant region (IGKC) gene.", "notes": "Dominant human kappa light chain constant region. Accounts for ~60% of human antibody light chains." }, { "id": "VBASE3_C_HUMAN_IGKC_KM1", "genbank_accession": "J00253", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00253", "genbank_record_file": "data/constant_regions/genbank_records/J00253.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGK", "gene": "IGKC", "allele": "02", "allotype": "Km(1)", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 107, "full_sequence": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKAYACEVTHQGLSSPVTKSFNRGEC", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKAYACEVTHQGLSSPVTKSFNRGEC", "c_domain_sequence": "", "tag_5p_aa_15": "RTVAAPSVFIFPPSD", "tag_5p_aa_30": "RTVAAPSVFIFPPSDEQLKSGTASVVCLLN", "diagnostic_motif": "Km1 allotype carries Ala153 and Leu191.", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "Homo sapiens immunoglobulin kappa constant region (IGKC) gene, Km1 allotype.", "description": "Homo sapiens immunoglobulin kappa constant region (IGKC) gene, Km1 allotype.", "notes": "Human kappa Km1 polymorphic variant." }, { "id": "VBASE3_C_HUMAN_IGLC1_01", "genbank_accession": "J00254", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00254", "genbank_record_file": "data/constant_regions/genbank_records/J00254.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGL", "gene": "IGLC1", "allele": "01", "allotype": "Mcg+", "isotype": "IgL1", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKANPTVTLFPPS", "tag_5p_aa_30": "GQPKANPTVTLFPPSSEELQANKATLVCLI", "diagnostic_motif": "N-terminal GQPKANPTVTLFPPS; position 6 has Asn (N), distinguishing IGLC1 from IGLC2/3/6/7 which carry Ala (A).", "genomic_locus_order": "IGL: 1/7 (Clambda1)", "genbank_definition": "Homo sapiens immunoglobulin lambda constant region 1 (IGLC1) gene.", "description": "Homo sapiens immunoglobulin lambda constant region 1 (IGLC1) gene.", "notes": "Human lambda-1 constant region." }, { "id": "VBASE3_C_HUMAN_IGLC2_01", "genbank_accession": "J00255", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00255", "genbank_record_file": "data/constant_regions/genbank_records/J00255.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGL", "gene": "IGLC2", "allele": "01", "allotype": "Kern- Oz-", "isotype": "IgL2", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKAAPSVTLFPPS", "tag_5p_aa_30": "GQPKAAPSVTLFPPSSEELQANKATLVCLI", "diagnostic_motif": "N-terminal GQPKAAPSVTLFPPS; position 45 has Ser (S) vs Gly in IGLC1; position 55 has Thr (T) vs Lys in IGLC1.", "genomic_locus_order": "IGL: 2/7 (Clambda2)", "genbank_definition": "Homo sapiens immunoglobulin lambda constant region 2 (IGLC2) gene.", "description": "Homo sapiens immunoglobulin lambda constant region 2 (IGLC2) gene.", "notes": "Most abundant human lambda light chain constant region. Used in Adalimumab-lambda, Dupilumab, etc." }, { "id": "VBASE3_C_HUMAN_IGLC3_01", "genbank_accession": "D87017", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/D87017", "genbank_record_file": "data/constant_regions/genbank_records/D87017.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGL", "gene": "IGLC3", "allele": "01", "allotype": "Kern- Oz+", "isotype": "IgL3", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKAAPSVTLFPPS", "tag_5p_aa_30": "GQPKAAPSVTLFPPSSEELQANKATLVCLI", "diagnostic_motif": "Oz+ marker carries Lys at position 100 (HKSYSC) vs Arg in IGLC2 (HRSYSC).", "genomic_locus_order": "IGL: 3/7 (Clambda3)", "genbank_definition": "Homo sapiens immunoglobulin lambda gene locus DNA, clone:75C12 (IGLC3).", "description": "Homo sapiens immunoglobulin lambda gene locus DNA, clone:75C12 (IGLC3).", "notes": "Human lambda-3 constant region." }, { "id": "VBASE3_C_HUMAN_IGLC6_01", "genbank_accession": "J03011", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J03011", "genbank_record_file": "data/constant_regions/genbank_records/J03011.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGL", "gene": "IGLC6", "allele": "01", "allotype": "Kern+", "isotype": "IgL6", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVKVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVKVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKAAPSVTLFPPS", "tag_5p_aa_30": "GQPKAAPSVTLFPPSSEELQANKATLVCLI", "diagnostic_motif": "Position 40 carries Lys (AVKVAW) vs Thr (AVTVAW) in IGLC1/2/3.", "genomic_locus_order": "IGL: 6/7 (Clambda6)", "genbank_definition": "Human immunoglobulin lambda-6 light chain gene, complete cds.", "description": "Human immunoglobulin lambda-6 light chain gene, complete cds.", "notes": "Human lambda-6 constant region." }, { "id": "VBASE3_C_HUMAN_IGLC7_01", "genbank_accession": "KM455557", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/KM455557", "genbank_record_file": "data/constant_regions/genbank_records/KM455557.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "IGL", "gene": "IGLC7", "allele": "01", "allotype": "Native", "isotype": "IgL7", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKAAPSVTLFPPS", "tag_5p_aa_30": "GQPKAAPSVTLFPPSSEELQANKATLVCLV", "diagnostic_motif": "Position 23 has Val (CLVSDF) vs Ile (CLISDF); position 28 has Asn (DFNPG) vs Tyr (DFYPG).", "genomic_locus_order": "IGL: 7/7 (Clambda7)", "genbank_definition": "Homo sapiens isolate HPOL3 immunoglobulin lambda constant region 7 (IGLC7) gene.", "description": "Homo sapiens isolate HPOL3 immunoglobulin lambda constant region 7 (IGLC7) gene.", "notes": "Human lambda-7 constant region." }, { "id": "VBASE3_C_HUMAN_TRAC_01", "genbank_accession": "M12959", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M12959", "genbank_record_file": "data/constant_regions/genbank_records/M12959.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRA", "gene": "TRAC", "allele": "01", "allotype": "Native", "isotype": "TCR-Alpha", "class": "TCR", "form": "Membrane", "full_length": 140, "full_sequence": "IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS", "tag_5p_aa_15": "IQNPDPAVYQLRDSK", "tag_5p_aa_30": "IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQ", "diagnostic_motif": "N-terminal IQNPDPAVYQLRDSK; invariant single C-alpha gene pairs with all functional TRAV and shared TRAV/TRDV rearrangements.", "genomic_locus_order": "TRA: 1/1 (TRAC)", "genbank_definition": "Human T-cell receptor active alpha-chain mRNA from JM cell line, complete cds.", "description": "Human T-cell receptor active alpha-chain mRNA from JM cell line, complete cds.", "notes": "Human T-cell receptor alpha-chain constant region. Encodes extracellular Ig-like domain, connecting peptide with interchain cysteine, transmembrane, and cytoplasmic tail." }, { "id": "VBASE3_C_HUMAN_TRBC1_01", "genbank_accession": "M12887", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M12887", "genbank_record_file": "data/constant_regions/genbank_records/M12887.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRB", "gene": "TRBC1", "allele": "01", "allotype": "Native", "isotype": "TCR-Beta1", "class": "TCR", "form": "Membrane", "full_length": 177, "full_sequence": "EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF", "tag_5p_aa_15": "EDLNKVFPPEVAVFE", "tag_5p_aa_30": "EDLNKVFPPEVAVFEPSEAEISHTQKATLV", "diagnostic_motif": "Position 5: Lys (EDLNKV); position 27: Phe (GFFPD); position 134: Gln (SASYQQ); position 169: Ala; C-terminus: RKDF.", "genomic_locus_order": "TRB: 1/2 (TRBC1)", "genbank_definition": "Human T-cell receptor germline beta-chain gene C-region C-beta-1, partial cds.", "description": "Human T-cell receptor germline beta-chain gene C-region C-beta-1, partial cds.", "notes": "Human TCR beta-chain constant region 1. Linked to TRBD1 and TRBJ1 clusters in tandem genomic cassette." }, { "id": "VBASE3_C_HUMAN_TRBC2_01", "genbank_accession": "M12888", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M12888", "genbank_record_file": "data/constant_regions/genbank_records/M12888.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRB", "gene": "TRBC2", "allele": "01", "allotype": "Native", "isotype": "TCR-Beta2", "class": "TCR", "form": "Membrane", "full_length": 177, "full_sequence": "EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS", "tag_5p_aa_15": "EDLKNVFPPEVAVFE", "tag_5p_aa_30": "EDLKNVFPPEVAVFEPSEAEISHTQKATLV", "diagnostic_motif": "Position 5: Asn (EDLKNV); position 27: Tyr (GFYPD); position 134: His (SASYHQ); position 169: Gly; C-terminus: KKNS.", "genomic_locus_order": "TRB: 2/2 (TRBC2)", "genbank_definition": "Human T-cell receptor germline beta-chain gene C-region C-beta-2, complete cds.", "description": "Human T-cell receptor germline beta-chain gene C-region C-beta-2, complete cds.", "notes": "Human TCR beta-chain constant region 2. Linked to TRBD2 and TRBJ2 clusters. Can be utilized by TRBD1/TRBJ1 or TRBD2/TRBJ2 rearrangements." }, { "id": "VBASE3_C_HUMAN_TRGC1_01", "genbank_accession": "BC030554", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BC030554", "genbank_record_file": "data/constant_regions/genbank_records/BC030554.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRG", "gene": "TRGC1", "allele": "01", "allotype": "Native", "isotype": "TCR-Gamma1", "class": "TCR", "form": "Membrane", "full_length": 173, "full_sequence": "DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS", "tag_5p_aa_15": "DKQLDADVSPKPTIF", "tag_5p_aa_30": "DKQLDADVSPKPTIFLPSIAETKLQKAGTY", "diagnostic_motif": "N-terminal DKQLDADVSPKPTIF; connects with TRG V-J rearrangements; encodes single connecting peptide exon forming disulfide-linked gammadelta TCR.", "genomic_locus_order": "TRG: 1/2 (TRGC1)", "genbank_definition": "Homo sapiens T cell receptor gamma constant 1, mRNA (cDNA clone MGC:46162), complete cds.", "description": "Homo sapiens T cell receptor gamma constant 1, mRNA (cDNA clone MGC:46162), complete cds.", "notes": "Human TCR gamma-chain constant region 1. Forms disulfide-linked heterodimer with TRDC." }, { "id": "VBASE3_C_HUMAN_TRGC2_01", "genbank_accession": "BC017861", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BC017861", "genbank_record_file": "data/constant_regions/genbank_records/BC017861.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRG", "gene": "TRGC2", "allele": "01", "allotype": "Native", "isotype": "TCR-Gamma2", "class": "TCR", "form": "Membrane", "full_length": 173, "full_sequence": "DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDIIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGIDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDIIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGIDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS", "tag_5p_aa_15": "DKQLDADVSPKPTIF", "tag_5p_aa_30": "DKQLDADVSPKPTIFLPSIAETKLQKAGTY", "diagnostic_motif": "Position 33: Ile (IIKIHW) vs Val in TRGC1; position 82: Ile (GIDQEI) vs Val in TRGC1; often forms non-disulfide-linked gammadelta TCR.", "genomic_locus_order": "TRG: 2/2 (TRGC2)", "genbank_definition": "Homo sapiens TCR gamma alternate reading frame protein, mRNA (cDNA clone MGC:22026), complete cds.", "description": "Homo sapiens TCR gamma alternate reading frame protein, mRNA (cDNA clone MGC:22026), complete cds.", "notes": "Human TCR gamma-chain constant region 2. Often associated with non-disulfide linked gamma-delta TCR forms." }, { "id": "VBASE3_C_HUMAN_TRDC_01", "genbank_accession": "M21624", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M21624", "genbank_record_file": "data/constant_regions/genbank_records/M21624.gb", "species": "Homo sapiens", "species_common": "Human", "locus": "TRD", "gene": "TRDC", "allele": "01", "allotype": "Native", "isotype": "TCR-Delta", "class": "TCR", "form": "Membrane", "full_length": 153, "full_sequence": "SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL", "tag_5p_aa_15": "SQPHTKPSVFVMKNG", "tag_5p_aa_30": "SQPHTKPSVFVMKNGTNVACLVKEFYPKDI", "diagnostic_motif": "N-terminal SQPHTKPSVFVMKNG; single C-delta gene located within the TRA locus between TRAV and TRAJ.", "genomic_locus_order": "TRD: 1/1 (TRDC)", "genbank_definition": "Human T-cell receptor delta chain mRNA (VJC-region), complete cds.", "description": "Human T-cell receptor delta chain mRNA (VJC-region), complete cds.", "notes": "Human TCR delta-chain constant region. Pairs with TRGC to form gammadelta T-cell receptor." }, { "id": "VBASE3_C_MOUSE_IGHM_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighm", "allele": "01", "allotype": "129S1 (Igh-6a)", "isotype": "IgM", "class": "IgM", "form": "Secreted", "full_length": 473, "full_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY", "ch1_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP", "hinge_sequence": "", "ch2_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA", "ch3_sequence": "PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN", "ch4_sequence": "VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCY", "tailpiece_sequence": "GKPTLYNVSLIMSDTGGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 368, "fc_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ESQSFPNVFPLVSCE", "tag_5p_aa_30": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLA", "diagnostic_motif": "N-terminal ESQSFPNVFPLVSCE distinguishes IgM from other isotypes; tailpiece contains Cys575 for J-chain incorporation.", "genomic_locus_order": "IGH: 1/8 (Cmu)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (Retter et al. 2007).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (Retter et al. 2007).", "notes": "Secreted pentameric/hexameric IgM heavy chain from strain 129S1. Terminal Cys575 forms disulfide link to J-chain." }, { "id": "VBASE3_C_MOUSE_IGHM_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighm", "allele": "01", "allotype": "129S1 (Igh-6a)", "isotype": "IgM", "class": "IgM", "form": "Membrane", "full_length": 474, "full_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTEGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK", "ch1_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP", "hinge_sequence": "", "ch2_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA", "ch3_sequence": "PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN", "ch4_sequence": "VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKST", "tailpiece_sequence": "", "m1_sequence": "EGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "EGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK", "fc_length": 328, "fc_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKST", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ESQSFPNVFPLVSCE", "tag_5p_aa_30": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLA", "diagnostic_motif": "Alternative splicing after CH4 residue 555 joins to M1/M2 exons; short KVK cytoplasmic tail interacts with CD79a/CD79b.", "genomic_locus_order": "IGH: 1/8 (Cmu)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00444).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00444).", "notes": "Membrane-bound B-cell receptor (BCR) IgM monomer from 129S1. Forms functional BCR complex non-covalently with CD79a/CD79b." }, { "id": "VBASE3_C_MOUSE_IGHD_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighd", "allele": "01", "allotype": "129S1 (Igh-5a)", "isotype": "IgD", "class": "IgD", "form": "Secreted", "full_length": 299, "full_sequence": "DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFPSWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPLDATTSCLSQTVLPGDLMVLPL", "ch1_sequence": "DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFP", "hinge_sequence": "SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIE", "ch2_sequence": "", "ch3_sequence": "AMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPL", "ch4_sequence": "", "tailpiece_sequence": "DATTSCLSQTVLPGDLMVLPL", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 190, "fc_sequence": "SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPLDATTSCLSQTVLPGDLMVLPL", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "DKKEPDMFLLSECKA", "tag_5p_aa_30": "DKKEPDMFLLSECKAPEENEKINLGCLVIG", "diagnostic_motif": "N-terminal DKKEPDMFLLSECKA; contains elongated flexible hinge and secretory tailpiece.", "genomic_locus_order": "IGH: 2/8 (Cdelta)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00448).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00448).", "notes": "Secreted murine serum IgD from strain 129S1. Produced in trace amounts via differential alternative polyadenylation." }, { "id": "VBASE3_C_MOUSE_IGHD_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighd", "allele": "01", "allotype": "129S1 (Igh-5a)", "isotype": "IgD", "class": "IgD", "form": "Membrane", "full_length": 314, "full_sequence": "DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFPSWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSIVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIKVK", "ch1_sequence": "DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFP", "hinge_sequence": "SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIE", "ch2_sequence": "", "ch3_sequence": "AMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPS", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "IVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIK", "m2_sequence": "VK", "membrane_anchor_sequence": "IVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIKVK", "fc_length": 148, "fc_sequence": "SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPS", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "DKKEPDMFLLSECKA", "tag_5p_aa_30": "DKKEPDMFLLSECKAPEENEKINLGCLVIG", "diagnostic_motif": "Spliced after CH3 to 52-aa extracellular stalk/TM exon (M1) and short cytoplasmic VK tail (M2).", "genomic_locus_order": "IGH: 2/8 (Cdelta)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00450).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00450).", "notes": "Membrane-bound IgD BCR from strain 129S1. Co-expressed with membrane IgM on naive follicular mature B cells." }, { "id": "VBASE3_C_MOUSE_IGHG3_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg3", "allele": "01", "allotype": "129S1 (Igh-8a)", "isotype": "IgG3", "class": "IgG", "form": "Secreted", "full_length": 330, "full_sequence": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "ch1_sequence": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI", "hinge_sequence": "EPRIPKPSTPPGSSCP", "ch2_sequence": "PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK", "ch3_sequence": "GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 233, "fc_sequence": "EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ATTTAPSVYPLVPGC", "tag_5p_aa_30": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVK", "diagnostic_motif": "N-terminal ATTTAPSVYPLVPGC; characteristic 15-aa proline-rich hinge.", "genomic_locus_order": "IGH: 3/8 (Cgamma3)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451).", "notes": "Secreted murine IgG3 heavy chain from 129S1. Self-associates via Fc-Fc contacts; primary response against carbohydrate antigens." }, { "id": "VBASE3_C_MOUSE_IGHG3_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg3", "allele": "01", "allotype": "129S1 (Igh-8a)", "isotype": "IgG3", "class": "IgG", "form": "Membrane", "full_length": 398, "full_sequence": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPLELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVQVKQTAIPDYRNMIGQGA", "ch1_sequence": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI", "hinge_sequence": "EPRIPKPSTPPGSSCP", "ch2_sequence": "PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK", "ch3_sequence": "GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "LELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK", "m2_sequence": "VKWIFSSVVQVKQTAIPDYRNMIGQGA", "membrane_anchor_sequence": "LELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVQVKQTAIPDYRNMIGQGA", "fc_length": 231, "fc_sequence": "EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ATTTAPSVYPLVPGC", "tag_5p_aa_30": "ATTTAPSVYPLVPGCSDTSGSSVTLGCLVK", "diagnostic_motif": "Spliced after CH3 to 44-aa M1 TM domain and 27-aa cytoplasmic signaling tail.", "genomic_locus_order": "IGH: 3/8 (Cgamma3)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / D78343).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / D78343).", "notes": "Membrane-bound IgG3 BCR monomer from strain 129S1." }, { "id": "VBASE3_C_MOUSE_IGHG1_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg1", "allele": "01", "allotype": "129S1 (Igh-4a)", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 324, "full_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "ch1_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI", "hinge_sequence": "VPRDCGCKPCI", "ch2_sequence": "CTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK", "ch3_sequence": "GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 227, "fc_sequence": "VPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGS", "tag_5p_aa_30": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK", "diagnostic_motif": "N-terminal AKTTPPSVYPLAPGS; canonical mouse Th2-switched subclass.", "genomic_locus_order": "IGH: 4/8 (Cgamma1)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00443).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00443).", "notes": "Secreted murine IgG1 heavy chain from 129S1. Dominant antibody in Th2-mediated responses; binds Fc\u03b3RIII." }, { "id": "VBASE3_C_MOUSE_IGHG1_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg1", "allele": "01", "allotype": "129S1 (Igh-4a)", "isotype": "IgG1", "class": "IgG", "form": "Membrane", "full_length": 391, "full_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPLQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFKVKWIFSSVVELKQTLVPEYKNMIGQAP", "ch1_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI", "hinge_sequence": "VPRDCGCKPCI", "ch2_sequence": "CTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK", "ch3_sequence": "GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "LQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFK", "m2_sequence": "VKWIFSSVVELKQTLVPEYKNMIGQAP", "membrane_anchor_sequence": "LQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFKVKWIFSSVVELKQTLVPEYKNMIGQAP", "fc_length": 225, "fc_sequence": "VPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGS", "tag_5p_aa_30": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK", "diagnostic_motif": "Spliced after CH3 residue 448 to 43-aa M1 TM exon and 27-aa cytoplasmic signaling tail (M2).", "genomic_locus_order": "IGH: 4/8 (Cgamma1)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00454).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00454).", "notes": "Membrane-bound IgG1 BCR monomer from strain 129S1." }, { "id": "VBASE3_C_MOUSE_IGHG2B_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2b", "allele": "01", "allotype": "129S1 (Igh-3a)", "isotype": "IgG2b", "class": "IgG", "form": "Secreted", "full_length": 336, "full_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "ch1_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL", "hinge_sequence": "EPSGPISTINPCPPCKECHKCP", "ch2_sequence": "APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK", "ch3_sequence": "GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 239, "fc_sequence": "EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGC", "tag_5p_aa_30": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK", "diagnostic_motif": "N-terminal AKTTPPSVYPLAPGC; potent Fc\u03b3RIV engagement.", "genomic_locus_order": "IGH: 5/8 (Cgamma2b)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00445).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00445).", "notes": "Secreted murine IgG2b heavy chain from 129S1. High affinity for mouse Fc\u03b3RIV; widely utilized in target-depleting monoclonal antibodies." }, { "id": "VBASE3_C_MOUSE_IGHG2B_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2b", "allele": "01", "allotype": "129S1 (Igh-3a)", "isotype": "IgG2b", "class": "IgG", "form": "Membrane", "full_length": 404, "full_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA", "ch1_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL", "hinge_sequence": "EPSGPISTINPCPPCKECHKCP", "ch2_sequence": "APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK", "ch3_sequence": "GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "LDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFK", "m2_sequence": "VKWIFSSVVELKQKISPDYRNMIGQGA", "membrane_anchor_sequence": "LDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA", "fc_length": 237, "fc_sequence": "EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGC", "tag_5p_aa_30": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK", "diagnostic_motif": "Spliced after CH3 to 44-aa M1 TM domain and 27-aa cytoplasmic signaling tail.", "genomic_locus_order": "IGH: 5/8 (Cgamma2b)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00462).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00462).", "notes": "Membrane-bound IgG2b BCR monomer from strain 129S1." }, { "id": "VBASE3_C_MOUSE_IGHG2A_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2a", "allele": "01", "allotype": "129S1 / BALB/c (Igh-1a)", "isotype": "IgG2a", "class": "IgG", "form": "Secreted", "full_length": 330, "full_sequence": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "ch1_sequence": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI", "hinge_sequence": "EPRGPTIKPCPPCKCP", "ch2_sequence": "APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK", "ch3_sequence": "GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 233, "fc_sequence": "EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTAPSVYPLAPVC", "tag_5p_aa_30": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVK", "diagnostic_motif": "N-terminal AKTTAPSVYPLAPVC with APVCGD motif; authentic Igh-1a allotype present in 129 and BALB/c (absent in C57BL/6).", "genomic_locus_order": "IGH: 6/8 (Cgamma2a)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00444).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00444).", "notes": "Secreted murine IgG2a heavy chain. Potent complement fixation and ADCC; replaced by IgG2c in C57BL/6 mice." }, { "id": "VBASE3_C_MOUSE_IGHG2A_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2a", "allele": "01", "allotype": "129S1 / BALB/c (Igh-1a)", "isotype": "IgG2a", "class": "IgG", "form": "Membrane", "full_length": 398, "full_sequence": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "ch1_sequence": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI", "hinge_sequence": "EPRGPTIKPCPPCKCP", "ch2_sequence": "APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK", "ch3_sequence": "GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK", "m2_sequence": "VKWIFSSVVELKQTISPDYRNMIGQGA", "membrane_anchor_sequence": "LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "fc_length": 231, "fc_sequence": "EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTAPSVYPLAPVC", "tag_5p_aa_30": "AKTTAPSVYPLAPVCGDTTGSSVTLGCLVK", "diagnostic_motif": "Spliced after CH3 residue 448 to 44-aa M1 TM domain and 27-aa cytoplasmic tail.", "genomic_locus_order": "IGH: 6/8 (Cgamma2a)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00471).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00471).", "notes": "Membrane-bound IgG2a BCR monomer from 129S1 / BALB/c." }, { "id": "VBASE3_C_MOUSE_IGHE_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighe", "allele": "01", "allotype": "129S1 (Igh-7a)", "isotype": "IgE", "class": "IgE", "form": "Secreted", "full_length": 465, "full_sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPCNIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCYGKPTLYNVSLVMSDTAGTCY", "ch1_sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPC", "hinge_sequence": "", "ch2_sequence": "NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPK", "ch3_sequence": "ELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGK", "ch4_sequence": "GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY", "tailpiece_sequence": "GKPTLYNVSLVMSDTAGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 369, "fc_sequence": "NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCYGKPTLYNVSLVMSDTAGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SIRNPQLYPLKPCKG", "tag_5p_aa_30": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFP", "diagnostic_motif": "N-terminal SIRNPQLYPLKPC; 4-domain CH1-CH4 architecture lacking distinct genetic hinge.", "genomic_locus_order": "IGH: 7/8 (Cepsilon)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451).", "notes": "Secreted murine IgE heavy chain from 129S1. High-affinity binder to mouse Fc\u03b5RI on mast cells and basophils." }, { "id": "VBASE3_C_MOUSE_IGHE_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighe", "allele": "01", "allotype": "129S1 (Igh-7a)", "isotype": "IgE", "class": "IgE", "form": "Membrane", "full_length": 494, "full_sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPCNIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTLQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "ch1_sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPC", "hinge_sequence": "", "ch2_sequence": "NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPK", "ch3_sequence": "ELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGK", "ch4_sequence": "GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKST", "tailpiece_sequence": "", "m1_sequence": "LQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFK", "m2_sequence": "VKWIFSSVVELKQTISPDYRNMIGQGA", "membrane_anchor_sequence": "LQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "fc_length": 329, "fc_sequence": "NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKST", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SIRNPQLYPLKPCKG", "tag_5p_aa_30": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFP", "diagnostic_motif": "Spliced after CH4 to M1 TM stalk and cytoplasmic signaling tail (M2).", "genomic_locus_order": "IGH: 7/8 (Cepsilon)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / X03624).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / X03624).", "notes": "Membrane-bound IgE BCR monomer from strain 129S1." }, { "id": "VBASE3_C_MOUSE_IGHA_01", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Igha", "allele": "01", "allotype": "129S1 (Igh-2)", "isotype": "IgA", "class": "IgA", "form": "Secreted", "full_length": 362, "full_sequence": "SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSGPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY", "ch1_sequence": "SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS", "hinge_sequence": "GPTPPPPITIP", "ch2_sequence": "SCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT", "ch3_sequence": "NTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICY", "ch4_sequence": "", "tailpiece_sequence": "GKPTNVSVSVIMSEGDGICY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 262, "fc_sequence": "GPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SARNPTIYPLTLPPA", "tag_5p_aa_30": "SARNPTIYPLTLPPALSSDPVIIGCLIHDY", "diagnostic_motif": "N-terminal SARNPTIYPLTLPP distinguishes 129/C57 IgA from BALB/c IgA (which starts with EDLNPRVFPLSLCT).", "genomic_locus_order": "IGH: 8/8 (Calpha)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00475).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00475).", "notes": "Secreted murine dimeric/polymeric mucosal IgA from strain 129S1. Terminal Cys495 links to J-chain." }, { "id": "VBASE3_C_MOUSE_IGHA_01_MEMBRANE", "genbank_accession": "AJ851868", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ851868", "genbank_record_file": "data/constant_regions/genbank_records/AJ851868.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Igha", "allele": "01", "allotype": "129S1 (Igh-2)", "isotype": "IgA", "class": "IgA", "form": "Membrane", "full_length": 322, "full_sequence": "SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSGPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS", "ch1_sequence": "SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS", "hinge_sequence": "GPTPPPPITIP", "ch2_sequence": "SCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT", "ch3_sequence": "NTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 222, "fc_sequence": "GPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SARNPTIYPLTLPPA", "tag_5p_aa_30": "SARNPTIYPLTLPPALSSDPVIIGCLIHDY", "diagnostic_motif": "Spliced after CH3 residue 445 to 64-aa CH-M transmembrane and cytoplasmic signaling tail.", "genomic_locus_order": "IGH: 8/8 (Calpha)", "genbank_definition": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / K00691).", "description": "Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / K00691).", "notes": "Membrane-bound IgA BCR monomer from strain 129S1." }, { "id": "VBASE3_C_MOUSE_IGHM_C57BL6", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighm", "allele": "04", "allotype": "C57BL/6 (Igh-6b)", "isotype": "IgM", "class": "IgM", "form": "Secreted", "full_length": 473, "full_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY", "ch1_sequence": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP", "hinge_sequence": "", "ch2_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA", "ch3_sequence": "PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN", "ch4_sequence": "VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCY", "tailpiece_sequence": "GKPTLYNVSLIMSDTGGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 368, "fc_sequence": "AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ESQSFPNVFPLVSCE", "tag_5p_aa_30": "ESQSFPNVFPLVSCESPLSDKNLVAMGCLA", "diagnostic_motif": "N-terminal ESQSFPNVFPLVSCE; C57BL/6 Igh-6b allotype.", "genomic_locus_order": "IGH: 1/8 (Cmu)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cmu gene (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cmu gene (BK063712).", "notes": "Secreted IgM heavy chain from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHG1_C57BL6", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg1", "allele": "02", "allotype": "C57BL/6 (Igh-4b)", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 324, "full_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTCPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "ch1_sequence": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI", "hinge_sequence": "VPRDCGCKPCICT", "ch2_sequence": "CPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK", "ch3_sequence": "GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 227, "fc_sequence": "VPRDCGCKPCICTCPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGS", "tag_5p_aa_30": "AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK", "diagnostic_motif": "N-terminal AKTTPPSVYPLAPGS; C57BL/6 Igh-4b allotype.", "genomic_locus_order": "IGH: 4/8 (Cgamma1)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma1 gene (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma1 gene (BK063712).", "notes": "Secreted IgG1 heavy chain from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHG2B_C57BL6", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2b", "allele": "03", "allotype": "C57BL/6 (Igh-3b)", "isotype": "IgG2b", "class": "IgG", "form": "Secreted", "full_length": 336, "full_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "ch1_sequence": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL", "hinge_sequence": "EPSGPISTINPCPPCKECHKCP", "ch2_sequence": "APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK", "ch3_sequence": "GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 239, "fc_sequence": "EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTPPSVYPLAPGC", "tag_5p_aa_30": "AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK", "diagnostic_motif": "N-terminal AKTTPPSVYPLAPGC; C57BL/6 Igh-3b allotype.", "genomic_locus_order": "IGH: 5/8 (Cgamma2b)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2b gene (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2b gene (BK063712).", "notes": "Secreted IgG2b heavy chain from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHG2C_01", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2c", "allele": "03", "allotype": "C57BL/6 (Igh-1b)", "isotype": "IgG2c", "class": "IgG", "form": "Secreted", "full_length": 330, "full_sequence": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "ch1_sequence": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI", "hinge_sequence": "EPRGPTIKPCPPCKCP", "ch2_sequence": "APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK", "ch3_sequence": "GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 233, "fc_sequence": "EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTAPSVYPLAPVC", "tag_5p_aa_30": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVK", "diagnostic_motif": "N-terminal AKTTAPSVYPLAPVC with APVCGG motif; authentic C57BL/6 Igh-1b product replacing IgG2a.", "genomic_locus_order": "IGH: 6/8 (Cgamma2c)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c gene (BK063712 / AB097847).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c gene (BK063712 / AB097847).", "notes": "Secreted murine IgG2c heavy chain. The authentic C57BL/6 isotype (Igh-1b allele). C57BL/6 mice lack the Ighg2a gene." }, { "id": "VBASE3_C_MOUSE_IGHG2C_01_MEMBRANE", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg2c", "allele": "03", "allotype": "C57BL/6 (Igh-1b)", "isotype": "IgG2c", "class": "IgG", "form": "Membrane", "full_length": 398, "full_sequence": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "ch1_sequence": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI", "hinge_sequence": "EPRGPTIKPCPPCKCP", "ch2_sequence": "APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK", "ch3_sequence": "GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK", "m2_sequence": "VKWIFSSVVELKQTISPDYRNMIGQGA", "membrane_anchor_sequence": "LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA", "fc_length": 231, "fc_sequence": "EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "AKTTAPSVYPLAPVC", "tag_5p_aa_30": "AKTTAPSVYPLAPVCGGTTGSSVTLGCLVK", "diagnostic_motif": "Spliced after CH3 residue 448 to 44-aa M1 TM domain and 27-aa cytoplasmic tail.", "genomic_locus_order": "IGH: 6/8 (Cgamma2c)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c membrane exons (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c membrane exons (BK063712).", "notes": "Membrane-bound IgG2c BCR monomer from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHG3_C57BL6", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Ighg3", "allele": "03", "allotype": "C57BL/6 (Igh-8b)", "isotype": "IgG3", "class": "IgG", "form": "Secreted", "full_length": 330, "full_sequence": "ATTTAPSVYPLVPGCGDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "ch1_sequence": "ATTTAPSVYPLVPGCGDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI", "hinge_sequence": "EPRIPKPSTPPGSSCP", "ch2_sequence": "PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK", "ch3_sequence": "GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 233, "fc_sequence": "EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ATTTAPSVYPLVPGC", "tag_5p_aa_30": "ATTTAPSVYPLVPGCGDTSGSSVTLGCLVK", "diagnostic_motif": "N-terminal ATTTAPSVYPLVPGC with PGCGDTS motif; C57BL/6 Igh-8b allotype.", "genomic_locus_order": "IGH: 3/8 (Cgamma3)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma3 gene (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma3 gene (BK063712).", "notes": "Secreted IgG3 heavy chain from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHA_C57BL6", "genbank_accession": "BK063712", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK063712", "genbank_record_file": "data/constant_regions/genbank_records/BK063712.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Igha", "allele": "09", "allotype": "C57BL/6 (Igh-2b)", "isotype": "IgA", "class": "IgA", "form": "Secreted", "full_length": 364, "full_sequence": "ESARNPTIYPLTLPRALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSPPPPPCPPCPPSCHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY", "ch1_sequence": "ESARNPTIYPLTLPRALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS", "hinge_sequence": "PPPPPCPPCPPS", "ch2_sequence": "CHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT", "ch3_sequence": "NNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICY", "ch4_sequence": "", "tailpiece_sequence": "GKPTNVSVSVIMSEGDGICY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 263, "fc_sequence": "PPPPPCPPCPPSCHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ESARNPTIYPLTLPR", "tag_5p_aa_30": "ESARNPTIYPLTLPRALSSDPVIIGCLIHD", "diagnostic_motif": "N-terminal ESARNPTIYPLTLPR; C57BL/6 Igh-2b allotype.", "genomic_locus_order": "IGH: 8/8 (Calpha)", "genbank_definition": "Mus musculus C57BL/6 chromosome 12 IGH locus: Calpha gene (BK063712).", "description": "Mus musculus C57BL/6 chromosome 12 IGH locus: Calpha gene (BK063712).", "notes": "Secreted IgA heavy chain from C57BL/6." }, { "id": "VBASE3_C_MOUSE_IGHA_BALBC", "genbank_accession": "J00449", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/J00449", "genbank_record_file": "data/constant_regions/genbank_records/J00449.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGH", "gene": "Igha", "allele": "02", "allotype": "BALB/c (Igh-2a)", "isotype": "IgA", "class": "IgA", "form": "Secreted", "full_length": 374, "full_sequence": "EDLNPRVFPLSLCTTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCYLAGKPTHVNVSVVMAEVDGTCY", "ch1_sequence": "EDLNPRVFPLSLCTTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVP", "hinge_sequence": "CPVPSTPPTPSPSTPPTPSPSC", "ch2_sequence": "CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS", "ch3_sequence": "GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY", "ch4_sequence": "", "tailpiece_sequence": "LAGKPTHVNVSVVMAEVDGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 275, "fc_sequence": "CPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCYLAGKPTHVNVSVVMAEVDGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "EDLNPRVFPLSLCTT", "tag_5p_aa_30": "EDLNPRVFPLSLCTTQPDGNVVIACLVQGF", "diagnostic_motif": "N-terminal EDLNPRVFPLSLCTT; BALB/c Igh-2a allotype with characteristic proline-rich hinge.", "genomic_locus_order": "IGH: 8/8 (Calpha)", "genbank_definition": "Mouse germline IgA chain gene, complete cds (BALB/c strain J00449).", "description": "Mouse germline IgA chain gene, complete cds (BALB/c strain J00449).", "notes": "Secreted BALB/c IgA heavy chain. Forms dimeric secretory IgA (sIgA) across mucosal surfaces." }, { "id": "VBASE3_C_MOUSE_IGKC_01", "genbank_accession": "V00807", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/V00807", "genbank_record_file": "data/constant_regions/genbank_records/V00807.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGK", "gene": "Igkc", "allele": "01", "allotype": "Standard (129 / BALB/c)", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 107, "full_sequence": "RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "c_domain_sequence": "", "tag_5p_aa_15": "RADAAPTVSIFPPSS", "tag_5p_aa_30": "RADAAPTVSIFPPSSEQLTSGGASVVCFLN", "diagnostic_motif": "N-terminal RADAAPTVSIFPPS; invariant C-terminal Cys214 pairs with heavy chain CH1 Cys.", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "Part of the germ line murine gene for kappa-immunoglobulin (V00807).", "description": "Part of the germ line murine gene for kappa-immunoglobulin (V00807).", "notes": "Pairs with >95% of all expressed murine antibody variable heavy domains." }, { "id": "VBASE3_C_MOUSE_IGKC_02", "genbank_accession": "AJ487682", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AJ487682", "genbank_record_file": "data/constant_regions/genbank_records/AJ487682.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGK", "gene": "Igkc", "allele": "02", "allotype": "C57BL/6", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 107, "full_sequence": "RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "c_domain_sequence": "", "tag_5p_aa_15": "RADAAPTVSIFPPSS", "tag_5p_aa_30": "RADAAPTVSIFPPSSEQLTSGGASVVCFLN", "diagnostic_motif": "N-terminal RADAAPTVSIFPPS.", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "Mus musculus IGKC gene for immunoglobulin kappa light chain, strain C57BL/6 (AJ487682).", "description": "Mus musculus IGKC gene for immunoglobulin kappa light chain, strain C57BL/6 (AJ487682).", "notes": "C57BL/6 mouse kappa constant region allele." }, { "id": "VBASE3_C_MOUSE_IGLC1_01", "genbank_accession": "BC119451", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BC119451", "genbank_record_file": "data/constant_regions/genbank_records/BC119451.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGL", "gene": "Iglc1", "allele": "01", "allotype": "Standard", "isotype": "IgL1", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKSSPSVTLFPPS", "tag_5p_aa_30": "GQPKSSPSVTLFPPSSEELETNKATLVCTI", "diagnostic_motif": "N-terminal GQPKSSPSVTLFPPS; primary mouse lambda isotype (~80% of rare mouse lambda chains).", "genomic_locus_order": "IGL: Tandem Cassette 1 (J1-C1)", "genbank_definition": "Mus musculus immunoglobulin lambda chain, variable 1, mRNA (cDNA clone BC119451).", "description": "Mus musculus immunoglobulin lambda chain, variable 1, mRNA (cDNA clone BC119451).", "notes": "Primary mouse lambda light chain constant region. Rearranges preferentially with Vlambda1." }, { "id": "VBASE3_C_MOUSE_IGLC2_01", "genbank_accession": "IMGT000117", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/IMGT000117", "genbank_record_file": "data/constant_regions/genbank_records/IMGT000117.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGL", "gene": "Iglc2", "allele": "01", "allotype": "Standard", "isotype": "IgL2", "class": "Lambda", "form": "Secreted", "full_length": 105, "full_sequence": "GQPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKSTPTLTVFPPS", "tag_5p_aa_30": "GQPKSTPTLTVFPPSSEELKENKATLVCLI", "diagnostic_motif": "N-terminal GQPKSTPTLTVFPPS.", "genomic_locus_order": "IGL: Tandem Cassette 2 (J2-C2)", "genbank_definition": "Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 2.", "description": "Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 2.", "notes": "Mouse lambda-2 constant region. Rearranges preferentially with Vlambda2." }, { "id": "VBASE3_C_MOUSE_IGLC3_01", "genbank_accession": "IMGT000117", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/IMGT000117", "genbank_record_file": "data/constant_regions/genbank_records/IMGT000117.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "IGL", "gene": "Iglc3", "allele": "01", "allotype": "Standard", "isotype": "IgL3", "class": "Lambda", "form": "Secreted", "full_length": 105, "full_sequence": "GQPKSTPTLTMFPPSPEELQENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEDNKYMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKSTPTLTMFPPSPEELQENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEDNKYMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKSTPTLTMFPPS", "tag_5p_aa_30": "GQPKSTPTLTMFPPSPEELQENKATLVCLI", "diagnostic_motif": "N-terminal GQPKSTPTLTMFPPS; distinguished by Met9 in tag.", "genomic_locus_order": "IGL: Tandem Cassette 3 (J3-C3)", "genbank_definition": "Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 3.", "description": "Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 3.", "notes": "Mouse lambda-3 constant region. Rearranges preferentially with Vlambda1." }, { "id": "VBASE3_C_MOUSE_TRAC_01", "genbank_accession": "M14506", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/M14506", "genbank_record_file": "data/constant_regions/genbank_records/M14506.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRA", "gene": "Trac", "allele": "01", "allotype": "Standard", "isotype": "TRAC", "class": "TCR", "form": "Membrane", "full_length": 137, "full_sequence": "DIQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNGAIAWSNQTSFTCQDIFKETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLRILLLKVAGFNLLMTLRLWSS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "DIQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNGAIAWSNQTSFTCQDIFKETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLRILLLKVAGFNLLMTLRLWSS", "tag_5p_aa_15": "DIQNPEPAVYQLKDP", "tag_5p_aa_30": "DIQNPEPAVYQLKDPRSQDSTLCLFTDFDS", "diagnostic_motif": "N-terminal DIQNPEPAVYQLKDP; pairs with TRBC beta chain in alpha/beta TCR.", "genomic_locus_order": "TRA: 1/1 (Calpha)", "genbank_definition": "Mouse T-cell receptor active alpha-chain mRNA from hybridoma T-s 34S-281 (M14506).", "description": "Mouse T-cell receptor active alpha-chain mRNA from hybridoma T-s 34S-281 (M14506).", "notes": "Mouse TCR alpha chain constant domain. Extracellular immunoglobulin domain, connecting peptide with interchain cysteine, TM and cytoplasmic tail." }, { "id": "VBASE3_C_MOUSE_TRBC1_01", "genbank_accession": "AE000665", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AE000665", "genbank_record_file": "data/constant_regions/genbank_records/AE000665.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRB", "gene": "Trbc1", "allele": "01", "allotype": "Standard", "isotype": "TRBC1", "class": "TCR", "form": "Membrane", "full_length": 172, "full_sequence": "EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKNS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKNS", "tag_5p_aa_15": "EDLRNVTPPKVSLFE", "tag_5p_aa_30": "EDLRNVTPPKVSLFEPSKAEIANKQKATLV", "diagnostic_motif": "N-terminal EDLRNVTPPKVSLFE; distinguished from TRBC2 by SYQQ (residues 133-136), SALV (163-166), and VKRK (173-176).", "genomic_locus_order": "TRB: Tandem Cassette 1 (Dbeta1-Jbeta1-Cbeta1)", "genbank_definition": "Mus musculus TCR beta locus: Cbeta1 constant gene (AE000665 / IMGT000132).", "description": "Mus musculus TCR beta locus: Cbeta1 constant gene (AE000665 / IMGT000132).", "notes": "Mouse TCR beta constant domain 1. Part of the first tandem cassette (Dbeta1-Jbeta1-Cbeta1); used exclusively by Jbeta1 cluster joins." }, { "id": "VBASE3_C_MOUSE_TRBC2_01", "genbank_accession": "AE000665", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AE000665", "genbank_record_file": "data/constant_regions/genbank_records/AE000665.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRB", "gene": "Trbc2", "allele": "03", "allotype": "Standard", "isotype": "TRBC2", "class": "TCR", "form": "Membrane", "full_length": 172, "full_sequence": "EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS", "tag_5p_aa_15": "EDLRNVTPPKVSLFE", "tag_5p_aa_30": "EDLRNVTPPKVSLFEPSKAEIANKQKATLV", "diagnostic_motif": "N-terminal EDLRNVTPPKVSLFE; distinguished from TRBC1 by SYHQ (residues 133-136), SGLV (163-166), and VKKK (173-176).", "genomic_locus_order": "TRB: Tandem Cassette 2 (Dbeta2-Jbeta2-Cbeta2)", "genbank_definition": "Mus musculus TCR beta locus: Cbeta2 constant gene (AE000665 / IMGT000132).", "description": "Mus musculus TCR beta locus: Cbeta2 constant gene (AE000665 / IMGT000132).", "notes": "Mouse TCR beta constant domain 2. Part of the second tandem cassette (Dbeta2-Jbeta2-Cbeta2); used by Jbeta2 cluster joins." }, { "id": "VBASE3_C_MOUSE_TRGC1_01", "genbank_accession": "AF037352", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF037352", "genbank_record_file": "data/constant_regions/genbank_records/AF037352.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRG", "gene": "Trgc1", "allele": "01", "allotype": "Standard", "isotype": "TRGC1", "class": "TCR", "form": "Membrane", "full_length": 109, "full_sequence": "KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKDGNTILDSQEGDTLKTNDTYMKFSWLTVPERAMGKEHRCIVKHENNKGGADQEIFFPSIKK", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKDGNTILDSQEGDTLKTNDTYMKFSWLTVPERAMGKEHRCIVKHENNKGGADQEIFFPSIKK", "tag_5p_aa_15": "KRLDADISPKPTIFL", "tag_5p_aa_30": "KRLDADISPKPTIFLPSVAETNLHKTGTYL", "diagnostic_motif": "N-terminal KRLDADISPKPTIFL.", "genomic_locus_order": "TRG: Cassette 1 (Jgamma1-Cgamma1)", "genbank_definition": "Mus musculus T cell receptor gamma locus: Cgamma1 gene (AF037352).", "description": "Mus musculus T cell receptor gamma locus: Cgamma1 gene (AF037352).", "notes": "Mouse TCR gamma constant domain 1. Expressed on canonical intraepithelial and dermal gamma/delta T cells." }, { "id": "VBASE3_C_MOUSE_TRGC2_01", "genbank_accession": "AF021335", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF021335", "genbank_record_file": "data/constant_regions/genbank_records/AF021335.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRG", "gene": "Trgc2", "allele": "01", "allotype": "Standard", "isotype": "TRGC2", "class": "TCR", "form": "Membrane", "full_length": 109, "full_sequence": "KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKNGNTILDSQEGDTLKTKGTYMKFSWLTVPERAMGKEHSCIVKHENNKGGADQEIFFPSIKK", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKNGNTILDSQEGDTLKTKGTYMKFSWLTVPERAMGKEHSCIVKHENNKGGADQEIFFPSIKK", "tag_5p_aa_15": "KRLDADISPKPTIFL", "tag_5p_aa_30": "KRLDADISPKPTIFLPSVAETNLHKTGTYL", "diagnostic_motif": "N-terminal KRLDADISPKPTIFL; distinguished by Asn50 and Ser84.", "genomic_locus_order": "TRG: Cassette 2 (Jgamma2-Cgamma2)", "genbank_definition": "Mus musculus T cell receptor gamma locus: Cgamma2 gene (AF021335).", "description": "Mus musculus T cell receptor gamma locus: Cgamma2 gene (AF021335).", "notes": "Mouse TCR gamma constant domain 2." }, { "id": "VBASE3_C_MOUSE_TRGC4_01", "genbank_accession": "AF021335", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF021335", "genbank_record_file": "data/constant_regions/genbank_records/AF021335.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRG", "gene": "Trgc4", "allele": "01", "allotype": "Standard", "isotype": "TRGC4", "class": "TCR", "form": "Membrane", "full_length": 109, "full_sequence": "KRTDSDFSPKPTIFLPSAAETNLHKAGTYLCLLEKFFPEVIRVYWKEKDGEKILESQEGNTIKTNDRYMKFSWLTVTEDSMAKEHSCIVKHENNKRGVDQEILFPPIGK", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "KRTDSDFSPKPTIFLPSAAETNLHKAGTYLCLLEKFFPEVIRVYWKEKDGEKILESQEGNTIKTNDRYMKFSWLTVTEDSMAKEHSCIVKHENNKRGVDQEILFPPIGK", "tag_5p_aa_15": "KRTDSDFSPKPTIFL", "tag_5p_aa_30": "KRTDSDFSPKPTIFLPSAAETNLHKAGTYL", "diagnostic_motif": "N-terminal KRTDSDFSPKPTIFL; distinguished by KRTDS and AAETN.", "genomic_locus_order": "TRG: Cassette 4 (Jgamma4-Cgamma4)", "genbank_definition": "Mus musculus T cell receptor gamma locus: Cgamma4 gene (AF021335).", "description": "Mus musculus T cell receptor gamma locus: Cgamma4 gene (AF021335).", "notes": "Mouse TCR gamma constant domain 4." }, { "id": "VBASE3_C_MOUSE_TRDC_01", "genbank_accession": "AE007512", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AE007512", "genbank_record_file": "data/constant_regions/genbank_records/AE007512.gb", "species": "Mus musculus", "species_common": "Mouse", "locus": "TRD", "gene": "Trdc", "allele": "01", "allotype": "Standard", "isotype": "TRDC", "class": "TCR", "form": "Membrane", "full_length": 92, "full_sequence": "SQPPAKPSVFIMKNGTNVACLVKDFYPKEVTISLRSSKKIVEFDPAIVISPSGKYSAVKLGQYGDSNSVTCSVQHNSETVHSTDFEPYANSF", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "SQPPAKPSVFIMKNGTNVACLVKDFYPKEVTISLRSSKKIVEFDPAIVISPSGKYSAVKLGQYGDSNSVTCSVQHNSETVHSTDFEPYANSF", "tag_5p_aa_15": "SQPPAKPSVFIMKNG", "tag_5p_aa_30": "SQPPAKPSVFIMKNGTNVACLVKDFYPKEV", "diagnostic_motif": "N-terminal SQPPAKPSVFIMKNG; pairs with TRGC gamma chain in gamma/delta TCR.", "genomic_locus_order": "TRD: 1/1 (Cdelta)", "genbank_definition": "Mus musculus T-cell receptor alpha/delta locus, complete sequence (AE007512).", "description": "Mus musculus T-cell receptor alpha/delta locus, complete sequence (AE007512).", "notes": "Mouse TCR delta constant domain." }, { "id": "VBASE3_C_CANINE_IGHG_A_01", "genbank_accession": "AF354264", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354264", "genbank_record_file": "data/constant_regions/genbank_records/AF354264.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-a", "allele": "01", "allotype": "Standard", "isotype": "IgG-A", "class": "IgG", "form": "Secreted", "full_length": 331, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKP", "hinge_sequence": "VFNECRCTDTPPCP", "ch2_sequence": "VPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARG", "ch3_sequence": "RAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 234, "fc_sequence": "VFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSC with PASNTKVDKP and VFNECRCTDTPPCP hinge; low effector function (Bedinvetmab format).", "genomic_locus_order": "IGH: Cgamma-A", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain A mRNA, complete cds (AF354264).", "description": "Canis familiaris immunoglobulin gamma heavy chain A mRNA, complete cds (AF354264).", "notes": "Secreted canine IgG-A heavy chain. Naturally low effector function, ideal for receptor antagonists." }, { "id": "VBASE3_C_CANINE_IGHG_A_MEM_01", "genbank_accession": "AF354264", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354264", "genbank_record_file": "data/constant_regions/genbank_records/AF354264.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-a", "allele": "01", "allotype": "Standard", "isotype": "IgG-A", "class": "IgG", "form": "Membrane", "full_length": 362, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKP", "hinge_sequence": "VFNECRCTDTPPCP", "ch2_sequence": "VPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARG", "ch3_sequence": "RAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "fc_length": 232, "fc_sequence": "VFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "Canine membrane BCR IgG-A; M1 transmembrane domain and short cytoplasmic VK signaling tail.", "genomic_locus_order": "IGH: Cgamma-A", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain A mRNA, membrane spliced form (AF354264).", "description": "Canis familiaris immunoglobulin gamma heavy chain A mRNA, membrane spliced form (AF354264).", "notes": "Membrane-bound canine IgG-A BCR monomer." }, { "id": "VBASE3_C_CANINE_IGHG_B_01", "genbank_accession": "AF354265", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354265", "genbank_record_file": "data/constant_regions/genbank_records/AF354265.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-b", "allele": "01", "allotype": "Standard", "isotype": "IgG-B", "class": "IgG", "form": "Secreted", "full_length": 335, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKP", "hinge_sequence": "VPKRENGRVPRPPDCPKCP", "ch2_sequence": "APEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARG", "ch3_sequence": "QAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 238, "fc_sequence": "VPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSC with PASKTKVDKP and VPKRENGR hinge; potent ADCC/CDC effector function (Lokivetmab format).", "genomic_locus_order": "IGH: Cgamma-B", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain B mRNA, complete cds (AF354265).", "description": "Canis familiaris immunoglobulin gamma heavy chain B mRNA, complete cds (AF354265).", "notes": "Secreted canine IgG-B heavy chain. The primary effector workhorse in canine therapeutic monoclonal antibodies." }, { "id": "VBASE3_C_CANINE_IGHG_B_MEM_01", "genbank_accession": "AF354265", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354265", "genbank_record_file": "data/constant_regions/genbank_records/AF354265.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-b", "allele": "01", "allotype": "Standard", "isotype": "IgG-B", "class": "IgG", "form": "Membrane", "full_length": 366, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKP", "hinge_sequence": "VPKRENGRVPRPPDCPKCP", "ch2_sequence": "APEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARG", "ch3_sequence": "QAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "fc_length": 236, "fc_sequence": "VPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "Canine membrane BCR IgG-B; M1 transmembrane domain and cytoplasmic VK signaling tail.", "genomic_locus_order": "IGH: Cgamma-B", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain B mRNA, membrane spliced form (AF354265).", "description": "Canis familiaris immunoglobulin gamma heavy chain B mRNA, membrane spliced form (AF354265).", "notes": "Membrane-bound canine IgG-B BCR monomer." }, { "id": "VBASE3_C_CANINE_IGHG_C_01", "genbank_accession": "AF354266", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354266", "genbank_record_file": "data/constant_regions/genbank_records/AF354266.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-c", "allele": "01", "allotype": "Standard", "isotype": "IgG-C", "class": "IgG", "form": "Secreted", "full_length": 333, "full_sequence": "ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKPVAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKP", "hinge_sequence": "VAKECECKCNCNNCPCP", "ch2_sequence": "GCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTP", "ch3_sequence": "GQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 236, "fc_sequence": "VAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSQSGSTVALACLVS", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSCGSQSG with VAKECECK hinge; intermediate canine IgG subclass.", "genomic_locus_order": "IGH: Cgamma-C", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain C mRNA, complete cds (AF354266).", "description": "Canis familiaris immunoglobulin gamma heavy chain C mRNA, complete cds (AF354266).", "notes": "Secreted canine IgG-C heavy chain." }, { "id": "VBASE3_C_CANINE_IGHG_C_MEM_01", "genbank_accession": "AF354266", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354266", "genbank_record_file": "data/constant_regions/genbank_records/AF354266.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-c", "allele": "01", "allotype": "Standard", "isotype": "IgG-C", "class": "IgG", "form": "Membrane", "full_length": 364, "full_sequence": "ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKPVAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "ch1_sequence": "ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKP", "hinge_sequence": "VAKECECKCNCNNCPCP", "ch2_sequence": "GCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTP", "ch3_sequence": "GQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "fc_length": 234, "fc_sequence": "VAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSQSGSTVALACLVS", "diagnostic_motif": "Canine membrane BCR IgG-C.", "genomic_locus_order": "IGH: Cgamma-C", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain C mRNA, membrane spliced form (AF354266).", "description": "Canis familiaris immunoglobulin gamma heavy chain C mRNA, membrane spliced form (AF354266).", "notes": "Membrane-bound canine IgG-C BCR monomer." }, { "id": "VBASE3_C_CANINE_IGHG_D_01", "genbank_accession": "AF354267", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354267", "genbank_record_file": "data/constant_regions/genbank_records/AF354267.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-d", "allele": "01", "allotype": "Standard", "isotype": "IgG-D", "class": "IgG", "form": "Secreted", "full_length": 331, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKPVPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKP", "hinge_sequence": "VPKESTCKCISPCP", "ch2_sequence": "VPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARG", "ch3_sequence": "QAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 234, "fc_sequence": "VPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSC with PASNTKVDKP and VPKESTCKCISPCP hinge; low effector function.", "genomic_locus_order": "IGH: Cgamma-D", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain D mRNA, complete cds (AF354267).", "description": "Canis familiaris immunoglobulin gamma heavy chain D mRNA, complete cds (AF354267).", "notes": "Secreted canine IgG-D heavy chain. Natural low-effector isotype." }, { "id": "VBASE3_C_CANINE_IGHG_D_MEM_01", "genbank_accession": "AF354267", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF354267", "genbank_record_file": "data/constant_regions/genbank_records/AF354267.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighg-d", "allele": "01", "allotype": "Standard", "isotype": "IgG-D", "class": "IgG", "form": "Membrane", "full_length": 362, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKPVPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKP", "hinge_sequence": "VPKESTCKCISPCP", "ch2_sequence": "VPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARG", "ch3_sequence": "QAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK", "fc_length": 232, "fc_sequence": "VPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "Canine membrane BCR IgG-D.", "genomic_locus_order": "IGH: Cgamma-D", "genbank_definition": "Canis familiaris immunoglobulin gamma heavy chain D mRNA, membrane spliced form (AF354267).", "description": "Canis familiaris immunoglobulin gamma heavy chain D mRNA, membrane spliced form (AF354267).", "notes": "Membrane-bound canine IgG-D BCR monomer." }, { "id": "VBASE3_C_CANINE_IGHM_SEC_01", "genbank_accession": "P01874", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/P01874", "genbank_record_file": "data/constant_regions/genbank_records/P01874.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighm", "allele": "01", "allotype": "Standard", "isotype": "IgM", "class": "IgM", "form": "Secreted", "full_length": 450, "full_sequence": "GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPVMLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGKPTLYNVSLVLSDTAGTCY", "ch1_sequence": "GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPV", "hinge_sequence": "", "ch2_sequence": "MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSD", "ch3_sequence": "QPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPK", "ch4_sequence": "GVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG", "tailpiece_sequence": "KPTLYNVSLVLSDTAGTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 346, "fc_sequence": "MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGKPTLYNVSLVLSDTAGTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "GSASAPSIFPLVSCE", "tag_5p_aa_30": "GSASAPSIFPLVSCENSNPTSTVAMGCLAR", "diagnostic_motif": "N-terminal GSASAPSIFPLVSCE distinguishes IgM from all other canine isotypes; tailpiece contains Cys for J-chain.", "genomic_locus_order": "IGH: 1/8 (Cmu)", "genbank_definition": "Canis lupus familiaris immunoglobulin mu heavy chain constant region protein (P01874).", "description": "Canis lupus familiaris immunoglobulin mu heavy chain constant region protein (P01874).", "notes": "Secreted pentameric/hexameric canine IgM backbone." }, { "id": "VBASE3_C_CANINE_IGHM_MEM_01", "genbank_accession": "P01874", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/P01874", "genbank_record_file": "data/constant_regions/genbank_records/P01874.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighm", "allele": "01", "allotype": "Standard", "isotype": "IgM", "class": "IgM", "form": "Membrane", "full_length": 472, "full_sequence": "GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPVMLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGEGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK", "ch1_sequence": "GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPV", "hinge_sequence": "", "ch2_sequence": "MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSD", "ch3_sequence": "QPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPK", "ch4_sequence": "GVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG", "tailpiece_sequence": "", "m1_sequence": "EGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "EGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK", "fc_length": 327, "fc_sequence": "MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "GSASAPSIFPLVSCE", "tag_5p_aa_30": "GSASAPSIFPLVSCENSNPTSTVAMGCLAR", "diagnostic_motif": "Canine membrane BCR IgM monomer; short KVK cytoplasmic signaling tail.", "genomic_locus_order": "IGH: 1/8 (Cmu)", "genbank_definition": "Canis lupus familiaris immunoglobulin mu heavy chain membrane BCR form (P01874 / AAEX03006126).", "description": "Canis lupus familiaris immunoglobulin mu heavy chain membrane BCR form (P01874 / AAEX03006126).", "notes": "Membrane-bound canine IgM BCR monomer." }, { "id": "VBASE3_C_CANINE_IGHA_SEC_01", "genbank_accession": "L36871", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/L36871", "genbank_record_file": "data/constant_regions/genbank_records/L36871.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Igha", "allele": "01", "allotype": "Standard", "isotype": "IgA", "class": "IgA", "form": "Secreted", "full_length": 343, "full_sequence": "SKTSPSVFPLSLCHQESEGYVVIGCLVQGFFPPEPVNVTWNAGKDSTSVKNFPPMKAATGSLYTMSSQLTLPAAQCPDDSSVKCQVQHASSPSKAVSVPCKDNSHPCHPCPSCNEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTEHIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLAGKPTHVNVSVVMAEVDGICY", "ch1_sequence": "SKTSPSVFPLSLCHQESEGYVVIGCLVQGFFPPEPVNVTWNAGKDSTSVKNFPPMKAATGSLYTMSSQLTLPAAQCPDDSSVKCQVQHASSPSKAVSVPCKD", "hinge_sequence": "NSHPCHPCPSC", "ch2_sequence": "NEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTE", "ch3_sequence": "HIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLA", "ch4_sequence": "", "tailpiece_sequence": "GKPTHVNVSVVMAEVDGICY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 241, "fc_sequence": "NSHPCHPCPSCNEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTEHIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLAGKPTHVNVSVVMAEVDGICY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SKTSPSVFPLSLCHQ", "tag_5p_aa_30": "SKTSPSVFPLSLCHQESEGYVVIGCLVQGF", "diagnostic_motif": "N-terminal SKTSPSVFPLSLCHQ; secretory IgA tailpiece with penultimate Cys for J-chain binding.", "genomic_locus_order": "IGH: 8/8 (Calpha)", "genbank_definition": "Canis familiaris IgA heavy chain constant region gene, partial cds (L36871).", "description": "Canis familiaris IgA heavy chain constant region gene, partial cds (L36871).", "notes": "Secreted dimeric canine IgA heavy chain." }, { "id": "VBASE3_C_CANINE_IGHE_SEC_01", "genbank_accession": "L36872", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/L36872", "genbank_record_file": "data/constant_regions/genbank_records/L36872.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGH", "gene": "Ighe", "allele": "01", "allotype": "Standard", "isotype": "IgE", "class": "IgE", "form": "Secreted", "full_length": 426, "full_sequence": "TSQDLSVFPLASCCKDNIASTSVTLGCLVTGYLPMSTTVTWDTGSLNKNVTTFPTTFHETYGLHSIVSQVTASGKWAKQRFTCSVAHAESTAINKTFSACALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSESDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPGKRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK", "ch1_sequence": "TSQDLSVFPLASCCKDNIASTSVTLGCLVTGYLPMSTTVTWDTGSLNKNVTTFPTTFHETYGLHSIVSQVTASGKWAKQRFTCSVAHAESTAINKTFSA", "hinge_sequence": "", "ch2_sequence": "CALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSE", "ch3_sequence": "SDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPG", "ch4_sequence": "KRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 327, "fc_sequence": "CALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSESDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPGKRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "TSQDLSVFPLASCCK", "tag_5p_aa_30": "TSQDLSVFPLASCCKDNIASTSVTLGCLVT", "diagnostic_motif": "N-terminal TSQDLSVFPLASCCK; four constant domains (CH1-CH4) without independent hinge.", "genomic_locus_order": "IGH: 7/8 (Cepsilon)", "genbank_definition": "Canis familiaris IgE heavy chain constant region gene, partial cds (L36872).", "description": "Canis familiaris IgE heavy chain constant region gene, partial cds (L36872).", "notes": "Secreted canine IgE heavy chain. High affinity for canine Fc-epsilon-RI; key mediator in canine atopic dermatitis." }, { "id": "VBASE3_C_CANINE_IGKC_01", "genbank_accession": "BK066061", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK066061", "genbank_record_file": "data/constant_regions/genbank_records/BK066061.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGK", "gene": "Igkc", "allele": "01", "allotype": "Standard (Boxer / Bernese)", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 110, "full_sequence": "RNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", "c_domain_sequence": "", "tag_5p_aa_15": "RNDAQPAVYLFQPSP", "tag_5p_aa_30": "RNDAQPAVYLFQPSPDQLHTGSASVVCLLN", "diagnostic_motif": "N-terminal RNDAQPAVYLFQPSP; minority canine light chain (~10% of canine antibodies).", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "TPA: Canis lupus familiaris IGKC*01 gene for immunoglobulin kappa light chain (BK066061).", "description": "TPA: Canis lupus familiaris IGKC*01 gene for immunoglobulin kappa light chain (BK066061).", "notes": "Secreted canine kappa light chain constant region." }, { "id": "VBASE3_C_CANINE_IGLC1_01", "genbank_accession": "NC_051830", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/NC_051830", "genbank_record_file": "data/constant_regions/genbank_records/NC_051830.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGL", "gene": "Iglc1", "allele": "01", "allotype": "Standard", "isotype": "IgL1", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKASPSVTLFPPS", "tag_5p_aa_30": "GQPKASPSVTLFPPSSEELGANKATLVCLI", "diagnostic_motif": "N-terminal GQPKASPSVTLFPPS; predominant light chain in canine antibodies (~90% Lambda).", "genomic_locus_order": "IGL: Tandem Cassette 1 (J1-C1)", "genbank_definition": "Canis lupus familiaris chromosome 26, IGLC1 constant region (NC_051830 / IMGT000003).", "description": "Canis lupus familiaris chromosome 26, IGLC1 constant region (NC_051830 / IMGT000003).", "notes": "Dominant canine lambda constant cassette. Standard light chain backbone for caninized therapeutic mAbs (Lokivetmab, Librela)." }, { "id": "VBASE3_C_CANINE_IGLC2_01", "genbank_accession": "NC_051830", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/NC_051830", "genbank_record_file": "data/constant_regions/genbank_records/NC_051830.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "IGL", "gene": "Iglc2", "allele": "01", "allotype": "Standard", "isotype": "IgL2", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKASPSVTLFPPS", "tag_5p_aa_30": "GQPKASPSVTLFPPSSEELGANKATLVCLI", "diagnostic_motif": "N-terminal GQPKASPSVTLFPPS with Val47 variant (SPVTQG); functional lambda cassette.", "genomic_locus_order": "IGL: Tandem Cassette 2 (J2-C2)", "genbank_definition": "Canis lupus familiaris chromosome 26, IGLC2 constant region (NC_051830 / IMGT000003).", "description": "Canis lupus familiaris chromosome 26, IGLC2 constant region (NC_051830 / IMGT000003).", "notes": "Canine lambda constant region allele with Val47." }, { "id": "VBASE3_C_CANINE_TRAC_01", "genbank_accession": "BK065026", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK065026", "genbank_record_file": "data/constant_regions/genbank_records/BK065026.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "TRA", "gene": "Trac", "allele": "01", "allotype": "Standard", "isotype": "TRAC", "class": "TCR", "form": "Membrane", "full_length": 133, "full_sequence": "VQDPDPSVYQMRSPKTGRTVCLFTDFDSQADFQKPEGATVISLNSTVLDMKVMDSKSNGALTWNSETNIECKENFQQPFYPSSNYSCDAKLIEKSFETDMDLNFYNLLVIGLRILLLKVIGFNLFMTLRLWSC", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "VQDPDPSVYQMRSPKTGRTVCLFTDFDSQADFQKPEGATVISLNSTVLDMKVMDSKSNGALTWNSETNIECKENFQQPFYPSSNYSCDAKLIEKSFETDMDLNFYNLLVIGLRILLLKVIGFNLFMTLRLWSC", "tag_5p_aa_15": "VQDPDPSVYQMRSPK", "tag_5p_aa_30": "VQDPDPSVYQMRSPKTGRTVCLFTDFDSQA", "diagnostic_motif": "N-terminal VQDPDPSVYQMRSPK; pairs with TRBC beta chain in canine alpha/beta TCR.", "genomic_locus_order": "TRA: 1/1 (Calpha)", "genbank_definition": "TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRAC gene (BK065026).", "description": "TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRAC gene (BK065026).", "notes": "Canine TCR alpha constant domain." }, { "id": "VBASE3_C_CANINE_TRBC1_01", "genbank_accession": "PV684572", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/PV684572", "genbank_record_file": "data/constant_regions/genbank_records/PV684572.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "TRB", "gene": "Trbc1", "allele": "01", "allotype": "Standard", "isotype": "TRBC1", "class": "TCR", "form": "Membrane", "full_length": 178, "full_sequence": "AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSVLVLMAKVKRKGS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSVLVLMAKVKRKGS", "tag_5p_aa_15": "AEDLQKVTPPTVTVF", "tag_5p_aa_30": "AEDLQKVTPPTVTVFEPSEAEISRTQKATL", "diagnostic_motif": "N-terminal AEDLQKVTPPTVTVF; distinguished from TRBC2 by Val168 in transmembrane domain.", "genomic_locus_order": "TRB: Tandem Cassette 1 (Dbeta1-Jbeta1-Cbeta1)", "genbank_definition": "Canis lupus familiaris T cell receptor beta constant region 1 (TRBC1) mRNA, partial cds (PV684572).", "description": "Canis lupus familiaris T cell receptor beta constant region 1 (TRBC1) mRNA, partial cds (PV684572).", "notes": "Canine TCR beta constant domain 1." }, { "id": "VBASE3_C_CANINE_TRBC2_01", "genbank_accession": "PV684573", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/PV684573", "genbank_record_file": "data/constant_regions/genbank_records/PV684573.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "TRB", "gene": "Trbc2", "allele": "01", "allotype": "Standard", "isotype": "TRBC2", "class": "TCR", "form": "Membrane", "full_length": 178, "full_sequence": "AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSILVLMAKVKRKGS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSILVLMAKVKRKGS", "tag_5p_aa_15": "AEDLQKVTPPTVTVF", "tag_5p_aa_30": "AEDLQKVTPPTVTVFEPSEAEISRTQKATL", "diagnostic_motif": "N-terminal AEDLQKVTPPTVTVF; distinguished from TRBC1 by Ile168 in transmembrane domain.", "genomic_locus_order": "TRB: Tandem Cassette 2 (Dbeta2-Jbeta2-Cbeta2)", "genbank_definition": "Canis lupus familiaris T cell receptor beta constant region 2 (TRBC2) mRNA, partial cds (PV684573).", "description": "Canis lupus familiaris T cell receptor beta constant region 2 (TRBC2) mRNA, partial cds (PV684573).", "notes": "Canine TCR beta constant domain 2." }, { "id": "VBASE3_C_CANINE_TRDC_01", "genbank_accession": "BK065026", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK065026", "genbank_record_file": "data/constant_regions/genbank_records/BK065026.gb", "species": "Canis lupus familiaris", "species_common": "Dog", "locus": "TRD", "gene": "Trdc", "allele": "01", "allotype": "Standard", "isotype": "TRDC", "class": "TCR", "form": "Membrane", "full_length": 157, "full_sequence": "SQLPAKPSVFTMRNGTAVACLVKDFYPKAINIRLESSKKLEEYDTAIAISPSGKYSAVKLGRYADPNSVTCSVEHNNEIVHSTDFEPKKKPSGNTKPTEPANVEQMSESFYAPKVHHSSEFTTGTVNMLSLTVLGLRMVFAKSLAINFVLTAKLFFF", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "SQLPAKPSVFTMRNGTAVACLVKDFYPKAINIRLESSKKLEEYDTAIAISPSGKYSAVKLGRYADPNSVTCSVEHNNEIVHSTDFEPKKKPSGNTKPTEPANVEQMSESFYAPKVHHSSEFTTGTVNMLSLTVLGLRMVFAKSLAINFVLTAKLFFF", "tag_5p_aa_15": "SQLPAKPSVFTMRNG", "tag_5p_aa_30": "SQLPAKPSVFTMRNGTAVACLVKDFYPKAI", "diagnostic_motif": "N-terminal SQLPAKPSVFTMRNG; pairs with TRGC gamma chain in canine gamma/delta TCR.", "genomic_locus_order": "TRD: 1/1 (Cdelta)", "genbank_definition": "TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRDC gene (BK065026).", "description": "TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRDC gene (BK065026).", "notes": "Canine TCR delta constant domain." }, { "id": "VBASE3_C_RABBIT_IGHG_01", "genbank_accession": "X51647", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/X51647", "genbank_record_file": "data/constant_regions/genbank_records/X51647.gb", "species": "Oryctolagus cuniculus", "species_common": "Rabbit", "locus": "IGH", "gene": "IGHG", "allele": "01", "allotype": "Native", "isotype": "IgG", "class": "IgG", "form": "Secreted", "full_length": 324, "full_sequence": "GQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKPTCPPPELLGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK", "ch1_sequence": "GQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTV", "hinge_sequence": "APSTCSKPTCPPPEL", "ch2_sequence": "LGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARG", "ch3_sequence": "QPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 229, "fc_sequence": "APSTCSKPTCPPPELLGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKAPSVFPLAPCC", "tag_5p_aa_30": "GQPKAPSVFPLAPCCGDTPSSTVTLGCLVK", "diagnostic_motif": "N-terminal GQPKAPSVFPLAPCC.", "genomic_locus_order": "IGH: Cgamma", "genbank_definition": "O.cuniculus gene for C alpha1 IgA heavy chain constant region.", "description": "O.cuniculus gene for C alpha1 IgA heavy chain constant region.", "notes": "Standard rabbit IgG backbone. Widely used for ultra-high affinity research and diagnostic mAbs." }, { "id": "VBASE3_C_LLAMA_IGHG1_01", "genbank_accession": "AF246473", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF246473", "genbank_record_file": "data/constant_regions/genbank_records/AF246473.gb", "species": "Lama glama", "species_common": "Llama", "locus": "IGH", "gene": "IGHG1", "allele": "01", "allotype": "Classical", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 350, "full_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSQTFTCNVAHPASKTKVDKPVEPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSQTFTCNVAHPASKTKVDKPV", "hinge_sequence": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCP", "ch2_sequence": "APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 252, "fc_sequence": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGSTSGSTVALACLVS", "diagnostic_motif": "Conventional heavy chain with full CH1; pairs with light chains.", "genomic_locus_order": "IGH: Cgamma1", "genbank_definition": "Lama glama immunoglobulin gamma-1 heavy chain constant region gene.", "description": "Lama glama immunoglobulin gamma-1 heavy chain constant region gene.", "notes": "Conventional heavy chain with full CH1. Pairs with light chains." }, { "id": "VBASE3_C_LLAMA_IGHG2_01", "genbank_accession": "AF246474", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF246474", "genbank_record_file": "data/constant_regions/genbank_records/AF246474.gb", "species": "Lama glama", "species_common": "Llama", "locus": "IGH", "gene": "IGHG2", "allele": "01", "allotype": "HCAb-LongHinge", "isotype": "IgG2", "class": "HCAb", "form": "Secreted", "full_length": 252, "full_sequence": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch1_sequence": "", "hinge_sequence": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCP", "ch2_sequence": "APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 252, "fc_sequence": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "EPKIPQPQPKPQPQP", "tag_5p_aa_30": "EPKIPQPQPKPQPQPQPQPKPQPKPEPECT", "diagnostic_motif": "Lacks CH1 domain; long 35-aa hinge directly connects VHH domain to CH2.", "genomic_locus_order": "IGH: Cgamma2", "genbank_definition": "Lama glama immunoglobulin gamma-2 heavy chain constant region (HCAb, lacks CH1).", "description": "Lama glama immunoglobulin gamma-2 heavy chain constant region (HCAb, lacks CH1).", "notes": "Autonomous Heavy-Chain-Only (HCAb) antibody. Splice site mutation causes direct splicing from VHH to long hinge." }, { "id": "VBASE3_C_LLAMA_IGHG3_01", "genbank_accession": "AF246475", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF246475", "genbank_record_file": "data/constant_regions/genbank_records/AF246475.gb", "species": "Lama glama", "species_common": "Llama", "locus": "IGH", "gene": "IGHG3", "allele": "01", "allotype": "HCAb-ShortHinge", "isotype": "IgG3", "class": "HCAb", "form": "Secreted", "full_length": 228, "full_sequence": "EPKTPKPQPCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch1_sequence": "", "hinge_sequence": "EPKTPKPQPCP", "ch2_sequence": "APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK", "ch3_sequence": "GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 228, "fc_sequence": "EPKTPKPQPCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "EPKTPKPQPCPAPEL", "tag_5p_aa_30": "EPKTPKPQPCPAPELLGGPSVFIFPPKPKD", "diagnostic_motif": "Lacks CH1 domain; short 11-aa hinge (EPKTPKPQPCP) connects VHH to CH2.", "genomic_locus_order": "IGH: Cgamma3", "genbank_definition": "Lama glama immunoglobulin gamma-3 heavy chain constant region (HCAb, lacks CH1).", "description": "Lama glama immunoglobulin gamma-3 heavy chain constant region (HCAb, lacks CH1).", "notes": "Short 11-residue hinge HCAb. Directly connects VHH nanobody domain to Fc." }, { "id": "VBASE3_C_BOVINE_IGHG1_01", "genbank_accession": "X16701", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/X16701", "genbank_record_file": "data/constant_regions/genbank_records/X16701.gb", "species": "Bos taurus", "species_common": "Cattle", "locus": "IGH", "gene": "IGHG1", "allele": "01", "allotype": "Native", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 325, "full_sequence": "ASTTAPKVYPLSSCCGDKSSSTVTLGCLVSSYMPEPVTVTWNSGALKSGVHTFPAVLQSGLYSLSSMVTVPSSSWLSQTVTCSVAHPASSTTVDKTVPPCPCPPCPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAKGQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK", "ch1_sequence": "ASTTAPKVYPLSSCCGDKSSSTVTLGCLVSSYMPEPVTVTWNSGALKSGVHTFPAVLQSGLYSLSSMVTVPSSSWLSQTVTCSVAHPASSTTVDKTV", "hinge_sequence": "PPCPCPP", "ch2_sequence": "CPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAK", "ch3_sequence": "GQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 228, "fc_sequence": "PPCPCPPCPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAKGQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPKVYPLSSCC", "tag_5p_aa_30": "ASTTAPKVYPLSSCCGDKSSSTVTLGCLVS", "diagnostic_motif": "N-terminal ASTTAPKVYPLSSCC; pairs with bovine ultralong CDR-H3 antibodies.", "genomic_locus_order": "IGH: Cgamma1", "genbank_definition": "Bovine Ig germline heavy chain gamma-1-chain gene C-region, 3' end.", "description": "Bovine Ig germline heavy chain gamma-1-chain gene C-region, 3' end.", "notes": "Bovine IgG1 heavy chain constant region. Naturally pairs with bovine ultralong CDR-H3 antibodies." }, { "id": "VBASE3_C_FELINE_IGHG1A_01", "genbank_accession": "AB016710", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AB016710", "genbank_record_file": "data/constant_regions/genbank_records/AB016710.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHG1A", "allele": "01", "allotype": "IgG1a", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 335, "full_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV", "hinge_sequence": "RKTDHPPGPKPCDCPKCP", "ch2_sequence": "PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAK", "ch3_sequence": "GQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 237, "fc_sequence": "RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGTTSGATVALACLVL", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSC with Pro at pos 6 (vs Ser in IgG2); Hinge RKTDHPPGPKPCDCPKCP (18 aa).", "genomic_locus_order": "IGH: 3/6 (Cgamma1a)", "genbank_definition": "Felis catus mRNA for IgG1 heavy chain, partial cds (AB016710, Kanai et al. 2000).", "description": "Felis catus mRNA for IgG1 heavy chain, partial cds (AB016710, Kanai et al. 2000).", "notes": "Primary feline IgG1 subclass backbone used in recombinant therapeutics including Frunevetmab (Solensia, Zoetis) for feline arthritis pain." }, { "id": "VBASE3_C_FELINE_IGHG1A_01_MBR", "genbank_accession": "BK083199", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK083199", "genbank_record_file": "data/constant_regions/genbank_records/BK083199.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHG1A", "allele": "01", "allotype": "IgG1a-BCR", "isotype": "IgG1", "class": "IgG", "form": "Membrane", "full_length": 404, "full_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQGA", "ch1_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV", "hinge_sequence": "RKTDHPPGPKPCDCPKCP", "ch2_sequence": "PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAK", "ch3_sequence": "GQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFK", "m2_sequence": "VKWIFSSVVELKRTIVPDYRNMIGQGA", "membrane_anchor_sequence": "ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQGA", "fc_length": 235, "fc_sequence": "RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGTTSGATVALACLVL", "diagnostic_motif": "Membrane BCR: 44-aa extracellular/transmembrane M1 stalk + 27-aa cytoplasmic signaling M2 tail.", "genomic_locus_order": "IGH: 3/6 (Cgamma1a-M)", "genbank_definition": "Felis catus isolate OcraZ1 IGH locus, IGHG1A membrane BCR form (BK083199 / AB016710).", "description": "Felis catus isolate OcraZ1 IGH locus, IGHG1A membrane BCR form (BK083199 / AB016710).", "notes": "Membrane-bound feline BCR IgG1a isoform expressed on memory B-cells." }, { "id": "VBASE3_C_FELINE_IGHG1B_01", "genbank_accession": "AB016711", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AB016711", "genbank_record_file": "data/constant_regions/genbank_records/AB016711.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHG1B", "allele": "01", "allotype": "IgG1b", "isotype": "IgG1", "class": "IgG", "form": "Secreted", "full_length": 335, "full_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDKGQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch1_sequence": "ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV", "hinge_sequence": "RKTDHPPGPKPCDCPKCP", "ch2_sequence": "PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDK", "ch3_sequence": "GQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 237, "fc_sequence": "RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDKGQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTAPSVFPLAPSC", "tag_5p_aa_30": "ASTTAPSVFPLAPSCGTTSGATVALACLVL", "diagnostic_motif": "N-terminal ASTTAPSVFPLAPSC; Allelic variant b differs by 8 residues in CH2/CH3 from allele a.", "genomic_locus_order": "IGH: 3/6 (Cgamma1b)", "genbank_definition": "Felis catus mRNA for IgG1 heavy chain, allele-b (AB016711, Kanai et al. 2000).", "description": "Felis catus mRNA for IgG1 heavy chain, allele-b (AB016711, Kanai et al. 2000).", "notes": "Feline IgG1b allelic variant (Kanai et al. 2000)." }, { "id": "VBASE3_C_FELINE_IGHG2_01", "genbank_accession": "KF811175", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/KF811175", "genbank_record_file": "data/constant_regions/genbank_records/KF811175.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHG2", "allele": "01", "allotype": "IgG2", "isotype": "IgG2", "class": "IgG", "form": "Secreted", "full_length": 335, "full_sequence": "ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTVPKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch1_sequence": "ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTV", "hinge_sequence": "PKTASTIESKTGEGPKCP", "ch2_sequence": "VPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAK", "ch3_sequence": "GQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 237, "fc_sequence": "PKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTASSVFPLAPSC", "tag_5p_aa_30": "ASTTASSVFPLAPSCGTTSGATVALACLVL", "diagnostic_motif": "N-terminal ASTTASSVFPLAPSC with Ser at pos 6 (vs Pro in IgG1); Hinge PKTASTIESKTGEGPKCP (18 aa).", "genomic_locus_order": "IGH: 4/6 (Cgamma2)", "genbank_definition": "Felis catus immunoglobulin G2 heavy chain constant region mRNA (KF811175, Strietzel et al. 2014, Zoetis).", "description": "Felis catus immunoglobulin G2 heavy chain constant region mRNA (KF811175, Strietzel et al. 2014, Zoetis).", "notes": "Feline IgG2 constant region characterised by Strietzel et al. 2014 (Zoetis). Intermediate/distinct effector profile." }, { "id": "VBASE3_C_FELINE_IGHG2_01_MBR", "genbank_accession": "BK083199", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK083199", "genbank_record_file": "data/constant_regions/genbank_records/BK083199.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHG2", "allele": "01", "allotype": "IgG2-BCR", "isotype": "IgG2", "class": "IgG", "form": "Membrane", "full_length": 404, "full_sequence": "ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTVPKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQAA", "ch1_sequence": "ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTV", "hinge_sequence": "PKTASTIESKTGEGPKCP", "ch2_sequence": "VPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAK", "ch3_sequence": "GQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFK", "m2_sequence": "VKWIFSSVVELKRTIVPDYRNMIGQAA", "membrane_anchor_sequence": "ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQAA", "fc_length": 235, "fc_sequence": "PKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ASTTASSVFPLAPSC", "tag_5p_aa_30": "ASTTASSVFPLAPSCGTTSGATVALACLVL", "diagnostic_motif": "Membrane BCR: 44-aa M1 stalk + 27-aa cytoplasmic M2 tail ending in GQAA.", "genomic_locus_order": "IGH: 4/6 (Cgamma2-M)", "genbank_definition": "Felis catus isolate OcraZ1 IGH locus, IGHG2 membrane BCR form (BK083199 / KF811175).", "description": "Felis catus isolate OcraZ1 IGH locus, IGHG2 membrane BCR form (BK083199 / KF811175).", "notes": "Membrane-bound feline BCR IgG2 isoform." }, { "id": "VBASE3_C_FELINE_IGHM_01", "genbank_accession": "BK083199", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK083199", "genbank_record_file": "data/constant_regions/genbank_records/BK083199.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHM", "allele": "01", "allotype": "Native", "isotype": "IgM", "class": "IgM", "form": "Secreted", "full_length": 454, "full_sequence": "TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPVPVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTGKPTLYNVSLVLSDTATTCY", "ch1_sequence": "TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPV", "hinge_sequence": "", "ch2_sequence": "PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACIL", "ch3_sequence": "NTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPK", "ch4_sequence": "DVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST", "tailpiece_sequence": "GKPTLYNVSLVLSDTATTCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 348, "fc_sequence": "PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTGKPTLYNVSLVLSDTATTCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "TSSRPNLFPLITCES", "tag_5p_aa_30": "TSSRPNLFPLITCESSLSDEPLVAMGCLAR", "diagnostic_motif": "N-terminal TSSRPNLFPLITCES; Secretory tailpiece GKPTLYNVSLVLSDTATTCY (20 aa).", "genomic_locus_order": "IGH: 1/6 (Cmu)", "genbank_definition": "Felis catus isolate OcraZ1 IGH locus, IGHM gene secreted form (BK083199 / D89025).", "description": "Felis catus isolate OcraZ1 IGH locus, IGHM gene secreted form (BK083199 / D89025).", "notes": "Feline IgM secreted heavy chain (454 aa, CH1-CH4 + tailpiece)." }, { "id": "VBASE3_C_FELINE_IGHM_01_MBR", "genbank_accession": "BK083199", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK083199", "genbank_record_file": "data/constant_regions/genbank_records/BK083199.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHM", "allele": "01", "allotype": "Native-BCR", "isotype": "IgM", "class": "IgM", "form": "Membrane", "full_length": 475, "full_sequence": "TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPVPVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTEGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFKVK", "ch1_sequence": "TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPV", "hinge_sequence": "", "ch2_sequence": "PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACIL", "ch3_sequence": "NTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPK", "ch4_sequence": "DVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST", "tailpiece_sequence": "", "m1_sequence": "EGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFK", "m2_sequence": "VK", "membrane_anchor_sequence": "EGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFKVK", "fc_length": 328, "fc_sequence": "PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "TSSRPNLFPLITCES", "tag_5p_aa_30": "TSSRPNLFPLITCESSLSDEPLVAMGCLAR", "diagnostic_motif": "Membrane BCR: Spliced after CH4 to 39-aa transmembrane M1 + 2-aa cytoplasmic tail VK.", "genomic_locus_order": "IGH: 1/6 (Cmu-M)", "genbank_definition": "Felis catus isolate OcraZ1 IGH locus, IGHM membrane BCR form (BK083199).", "description": "Felis catus isolate OcraZ1 IGH locus, IGHM membrane BCR form (BK083199).", "notes": "Feline membrane-bound naive B-cell receptor (BCR) IgM isoform (475 aa)." }, { "id": "VBASE3_C_FELINE_IGHA_01", "genbank_accession": "KY795050", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/KY795050", "genbank_record_file": "data/constant_regions/genbank_records/KY795050.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHA", "allele": "01", "allotype": "Native", "isotype": "IgA", "class": "IgA", "form": "Secreted", "full_length": 344, "full_sequence": "ESKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVEHYSSTSPAVSVPCRADPPPPCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMSDVEGVCY", "ch1_sequence": "ESKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVEHYSSTSPAVSVP", "hinge_sequence": "CRADPPPPCSPCNE", "ch2_sequence": "PRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVL", "ch3_sequence": "ENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRL", "ch4_sequence": "", "tailpiece_sequence": "AGKPTHVNVSVVMSDVEGVCY", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 244, "fc_sequence": "CRADPPPPCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMSDVEGVCY", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "ESKTSPRVFPLSLRT", "tag_5p_aa_30": "ESKTSPRVFPLSLRTSDPAGQVVIACLVQG", "diagnostic_motif": "N-terminal ESKTSPRVFPLSLRT; Hinge CRADPPPPCSPCNE (14 aa); Tailpiece AGKPTHVNVSVVMSDVEGVCY (21 aa).", "genomic_locus_order": "IGH: 6/6 (Calpha)", "genbank_definition": "Felis catus clone cat 2-IGHA-12 IgA constant region mRNA (KY795050, Lu et al. 2017).", "description": "Felis catus clone cat 2-IGHA-12 IgA constant region mRNA (KY795050, Lu et al. 2017).", "notes": "Feline mucosal IgA heavy chain constant region (335 aa, Lu et al. 2017)." }, { "id": "VBASE3_C_FELINE_IGHA_01_MBR", "genbank_accession": "BK083199", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/BK083199", "genbank_record_file": "data/constant_regions/genbank_records/BK083199.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGH", "gene": "IGHA", "allele": "01", "allotype": "Native-BCR", "isotype": "IgA", "class": "IgA", "form": "Membrane", "full_length": 394, "full_sequence": "SKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVQHYSSTSPAVSVPCRADPPPQCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLADSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTSVRGPADSREGPQY", "ch1_sequence": "SKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVQHYSSTSPAVSVPCRA", "hinge_sequence": "DPPPQCSPCNE", "ch2_sequence": "PRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVL", "ch3_sequence": "ENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLA", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "DSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTS", "m2_sequence": "VRGPADSREGPQY", "membrane_anchor_sequence": "DSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTSVRGPADSREGPQY", "fc_length": 221, "fc_sequence": "DPPPQCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLA", "cl_sequence": "", "c_domain_sequence": "", "tag_5p_aa_15": "SKTSPRVFPLSLRTS", "tag_5p_aa_30": "SKTSPRVFPLSLRTSDPAGQVVIACLVQGF", "diagnostic_motif": "Membrane BCR: Spliced after CH3 to 59-aa transmembrane M1 + 13-aa cytoplasmic tail VRGPADSREGPQY.", "genomic_locus_order": "IGH: 6/6 (Calpha-M)", "genbank_definition": "Felis catus isolate OcraZ1 IGH locus, IGHA membrane BCR form (BK083199 / KY795050).", "description": "Felis catus isolate OcraZ1 IGH locus, IGHA membrane BCR form (BK083199 / KY795050).", "notes": "Feline membrane-bound IgA BCR isoform (394 aa)." }, { "id": "VBASE3_C_FELINE_IGKC_01", "genbank_accession": "AF198257", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/AF198257", "genbank_record_file": "data/constant_regions/genbank_records/AF198257.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGK", "gene": "IGKC", "allele": "01", "allotype": "Native", "isotype": "IgK", "class": "Kappa", "form": "Secreted", "full_length": 110, "full_sequence": "RSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "RSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE", "c_domain_sequence": "", "tag_5p_aa_15": "RSDAQPSVFLFQPSL", "tag_5p_aa_30": "RSDAQPSVFLFQPSLDELHTGSASIVCILN", "diagnostic_motif": "N-terminal RSDAQPSVFLFQPSL; diagnostic RSDAQPS motif distinguishes cat kappa from dog (RNDAQPA) and human (RTVAAPS).", "genomic_locus_order": "IGK: 1/1 (Ckappa)", "genbank_definition": "Felis catus immunoglobulin kappa light chain mRNA, complete cds (AF198257, Heska Corp).", "description": "Felis catus immunoglobulin kappa light chain mRNA, complete cds (AF198257, Heska Corp).", "notes": "Feline kappa light chain constant region (107 aa). Natural light chain for Frunevetmab (Solensia)." }, { "id": "VBASE3_C_FELINE_IGLC1_01", "genbank_accession": "KY795178", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/KY795178", "genbank_record_file": "data/constant_regions/genbank_records/KY795178.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "IGL", "gene": "IGLC1", "allele": "01", "allotype": "Native", "isotype": "IgL1", "class": "Lambda", "form": "Secreted", "full_length": 106, "full_sequence": "GQPKSAPSVTLFPPSSEELSANKATLVCLISDFYPSGLTVAWKADGTPVTQGVETTKPSKQSNNKYAASSYLSLSPNEWKSHSRFTCQVTHEGSTVEKSVVPAECS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "GQPKSAPSVTLFPPSSEELSANKATLVCLISDFYPSGLTVAWKADGTPVTQGVETTKPSKQSNNKYAASSYLSLSPNEWKSHSRFTCQVTHEGSTVEKSVVPAECS", "c_domain_sequence": "", "tag_5p_aa_15": "GQPKSAPSVTLFPPS", "tag_5p_aa_30": "GQPKSAPSVTLFPPSSEELSANKATLVCLI", "diagnostic_motif": "N-terminal GQPKSAPSVTLFPPS with Ser at pos 6 (vs Ala in canine GQPKASPS and human GQPKAAPS).", "genomic_locus_order": "IGL: 1/11 (Clambda1)", "genbank_definition": "Felis catus clone cat 2-IGLC-1 IgG lambda chain constant region (KY795178 / KY795194, Lu et al. 2017).", "description": "Felis catus clone cat 2-IGLC-1 IgG lambda chain constant region (KY795178 / KY795194, Lu et al. 2017).", "notes": "Feline lambda light chain constant region (106 aa). Cat repertoires are ~60-80% lambda dominant." }, { "id": "VBASE3_C_FELINE_TRAC_01", "genbank_accession": "D89022", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/D89022", "genbank_record_file": "data/constant_regions/genbank_records/D89022.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "TRA", "gene": "TRAC", "allele": "01", "allotype": "Native", "isotype": "TRAC", "class": "TCR", "form": "Secreted", "full_length": 113, "full_sequence": "TSSKASNPSTISVCLFTDFDSEVNVNPSTESNMIRLKSTSLDMKTMDSKSNWALAWSNSFDLGCNSTFNYTFHSSSEFPCDANVVEKGFETDMNLNFDNLTVIMLRIIFLKAV", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "TSSKASNPSTISVCLFTDFDSEVNVNPSTESNMIRLKSTSLDMKTMDSKSNWALAWSNSFDLGCNSTFNYTFHSSSEFPCDANVVEKGFETDMNLNFDNLTVIMLRIIFLKAV", "tag_5p_aa_15": "TSSKASNPSTISVCL", "tag_5p_aa_30": "TSSKASNPSTISVCLFTDFDSEVNVNPSTE", "diagnostic_motif": "N-terminal TSSKASNPSTISVCL; single feline TRAC gene located on chromosome B3.", "genomic_locus_order": "TRA: 1/1 (Calpha)", "genbank_definition": "Felis catus mRNA for TCR alpha constant chain, partial cds (D89022, Cho et al. 1998 / Radtanakatikanon 2020).", "description": "Felis catus mRNA for TCR alpha constant chain, partial cds (D89022, Cho et al. 1998 / Radtanakatikanon 2020).", "notes": "Feline T-cell receptor alpha chain constant domain (113 aa)." }, { "id": "VBASE3_C_FELINE_TRBC1_01", "genbank_accession": "XM_045052894", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/XM_045052894", "genbank_record_file": "data/constant_regions/genbank_records/XM_045052894.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "TRB", "gene": "TRBC1", "allele": "01", "allotype": "Native", "isotype": "TRBC1", "class": "TCR", "form": "Secreted", "full_length": 177, "full_sequence": "EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGANVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGANVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS", "tag_5p_aa_15": "EDLKKVSPPKVTVFE", "tag_5p_aa_30": "EDLKKVSPPKVTVFEPSEAEISRTLKATLV", "diagnostic_motif": "N-terminal EDLKKVSPPKVTVFE; diagnostic Lys5 Lys6 (EDLKK) distinguishes feline TRBC from human (EDLNK/EDLKN) and canine (AEDLQ).", "genomic_locus_order": "TRB: Tandem Cassette 1", "genbank_definition": "Felis catus T cell receptor beta constant region 1 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020).", "description": "Felis catus T cell receptor beta constant region 1 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020).", "notes": "Feline T-cell receptor beta constant cassette 1 on chromosome A2 (177 aa, Radtanakatikanon et al. 2020)." }, { "id": "VBASE3_C_FELINE_TRBC2_01", "genbank_accession": "XM_045052894", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/XM_045052894", "genbank_record_file": "data/constant_regions/genbank_records/XM_045052894.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "TRB", "gene": "TRBC2", "allele": "01", "allotype": "Native", "isotype": "TRBC2", "class": "TCR", "form": "Secreted", "full_length": 177, "full_sequence": "EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGASVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGASVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS", "tag_5p_aa_15": "EDLKKVSPPKVTVFE", "tag_5p_aa_30": "EDLKKVSPPKVTVFEPSEAEISRTLKATLV", "diagnostic_motif": "N-terminal EDLKKVSPPKVTVFE; Ser101 (GASV) distinguishes TRBC2 from Asn101 (GANV) in TRBC1.", "genomic_locus_order": "TRB: Tandem Cassette 2", "genbank_definition": "Felis catus T cell receptor beta constant region 2 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020).", "description": "Felis catus T cell receptor beta constant region 2 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020).", "notes": "Feline T-cell receptor beta constant cassette 2 on chromosome A2 (177 aa)." }, { "id": "VBASE3_C_FELINE_TRDC_01", "genbank_accession": "D89018", "genbank_url": "https://www.ncbi.nlm.nih.gov/nuccore/D89018", "genbank_record_file": "data/constant_regions/genbank_records/D89018.gb", "species": "Felis catus", "species_common": "Domestic cat", "locus": "TRD", "gene": "TRDC", "allele": "01", "allotype": "Native", "isotype": "TRDC", "class": "TCR", "form": "Secreted", "full_length": 125, "full_sequence": "DFYPKDINIKLEPTKKLEEFDPAIVVSPSGKYSAVKLGRYEDPNSVTCSVEHNSEVVSSTNFEPRTNSSGTVKPKPTESENIKLTPKSISEPKATVRHSSQFTAGNVNMLSLTVLGLRMVFAKSL", "ch1_sequence": "", "hinge_sequence": "", "ch2_sequence": "", "ch3_sequence": "", "ch4_sequence": "", "tailpiece_sequence": "", "m1_sequence": "", "m2_sequence": "", "membrane_anchor_sequence": "", "fc_length": 0, "fc_sequence": "", "cl_sequence": "", "c_domain_sequence": "DFYPKDINIKLEPTKKLEEFDPAIVVSPSGKYSAVKLGRYEDPNSVTCSVEHNSEVVSSTNFEPRTNSSGTVKPKPTESENIKLTPKSISEPKATVRHSSQFTAGNVNMLSLTVLGLRMVFAKSL", "tag_5p_aa_15": "DFYPKDINIKLEPTK", "tag_5p_aa_30": "DFYPKDINIKLEPTKKLEEFDPAIVVSPSG", "diagnostic_motif": "N-terminal DFYPKDINIKLEPTK; nested within feline TRA locus on chromosome B3.", "genomic_locus_order": "TRD: 1/1 (Cdelta)", "genbank_definition": "Felis catus mRNA for TCR delta constant chain, partial cds (D89018, Cho et al. 1998 / Radtanakatikanon 2020).", "description": "Felis catus mRNA for TCR delta constant chain, partial cds (D89018, Cho et al. 1998 / Radtanakatikanon 2020).", "notes": "Feline T-cell receptor delta constant domain (125 aa)." } ] }