id genbank_accession genbank_url genbank_record_file species species_common locus gene allele allotype isotype class form full_length full_sequence ch1_sequence hinge_sequence ch2_sequence ch3_sequence ch4_sequence tailpiece_sequence m1_sequence m2_sequence membrane_anchor_sequence fc_length fc_sequence cl_sequence c_domain_sequence tag_5p_aa_15 tag_5p_aa_30 diagnostic_motif genomic_locus_order genbank_definition description notes VBASE3_C_HUMAN_IGHM_SEC_01 M21624 https://www.ncbi.nlm.nih.gov/nuccore/M21624 data/constant_regions/genbank_records/M21624.gb Homo sapiens Human IGH IGHM 01 Native IgM IgM Secreted 453 GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPV VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVP DQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPK GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG KPTLYNVSLVMSDTAGTCY 348 VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY GSASAPTLFPLVSCE GSASAPTLFPLVSCENSPSDTSSVAVGCLA N-terminal GSASAPTLFPLVSCE distinguishes IgM from all other isotypes; tailpiece contains Cys575 for J-chain incorporation. IGH: 1/9 (Cmu) Human immunoglobulin heavy chain constant region mu gene, complete cds. Human immunoglobulin heavy chain constant region mu gene, complete cds. Secreted pentameric/hexameric IgM backbone. Includes tailpiece C-terminal cysteine (Cys575) essential for J-chain covalent linkage. VBASE3_C_HUMAN_IGHM_MEM_01 X14939 https://www.ncbi.nlm.nih.gov/nuccore/X14939 data/constant_regions/genbank_records/X14939.gb Homo sapiens Human IGH IGHM 01 Native IgM IgM Membrane 475 GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPV VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVP DQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPK GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG EGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFK VK EGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK 329 VIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTG GSASAPTLFPLVSCE GSASAPTLFPLVSCENSPSDTSSVAVGCLA Alternative splicing after CH4 residue 555 joins to M1/M2 exons; short KVK cytoplasmic tail interacts with CD79a/CD79b (Igalpha/Igbeta). IGH: 1/9 (Cmu) Homo sapiens mRNA for membrane-bound immunoglobulin mu chain. Homo sapiens mRNA for membrane-bound immunoglobulin mu chain. Membrane-bound B-cell receptor (BCR) IgM monomer. Forms functional BCR signaling complex non-covalently coupled to CD79a/CD79b heterodimers. VBASE3_C_HUMAN_IGHD_SEC_01 K02875 https://www.ncbi.nlm.nih.gov/nuccore/K02875 data/constant_regions/genbank_records/K02875.gb Homo sapiens Human IGH IGHD 01 Native IgD IgD Secreted 384 APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWP ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECP SHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPA AQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS YVTDHGPMK 283 ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK APTKAPDVFPIISGC APTKAPDVFPIISGCRHPKDNSPVVLACLI N-terminal APTKAPDVFPIISGC; elongated 64-aa highly flexible hinge; 9-aa secretory tailpiece. IGH: 2/9 (Cdelta) Human germline IgD chain gene, C-region, complete cds. Human germline IgD chain gene, C-region, complete cds. Secreted serum IgD. Produced in trace amounts by alternative polyadenylation without class switch recombination. VBASE3_C_HUMAN_IGHD_MEM_01 BC063384 https://www.ncbi.nlm.nih.gov/nuccore/BC063384 data/constant_regions/genbank_records/BC063384.gb Homo sapiens Human IGH IGHD 01 Native IgD IgD Membrane 430 APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK APTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWP ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECP SHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPA AQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS YLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIK VK YLAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK 274 ESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPGSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVS APTKAPDVFPIISGC APTKAPDVFPIISGCRHPKDNSPVVLACLI Membrane M1/M2 exons spliced after CH3; co-expressed with mIgM on mature naive follicular B cells via alternative splicing. IGH: 2/9 (Cdelta) Homo sapiens immunoglobulin heavy constant delta, mRNA (cDNA clone MGC:75200 IMAGE:6549048), complete cds. Homo sapiens immunoglobulin heavy constant delta, mRNA (cDNA clone MGC:75200 IMAGE:6549048), complete cds. Membrane-bound IgD BCR. Co-expressed alongside membrane IgM on naive mature B cells through differential pre-mRNA cleavage and splicing. VBASE3_C_HUMAN_IGHG1_SEC_01 J00228 https://www.ncbi.nlm.nih.gov/nuccore/J00228 data/constant_regions/genbank_records/J00228.gb Homo sapiens Human IGH IGHG1 01 G1m17,1 IgG1 IgG Secreted 330 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV EPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 232 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPSS ASTKGPSVFPLAPSSKSTSGGTAALGCLVK CH1 residue 14 (Ser) distinguishes IgG1 from IgG2/3/4 (which have Cys14); residue 18 (Gly) distinguishes IgG1/3 from IgG2/4 (Ser18). IGH: 4/9 (Cgamma1) Homo sapiens immunoglobulin gamma-1 heavy chain constant region (IGHG1) gene, partial cds. Homo sapiens immunoglobulin gamma-1 heavy chain constant region (IGHG1) gene, partial cds. Canonical human IgG1 backbone. Backbone of Trastuzumab, Rituximab, Adalimumab. Potent ADCC and C1q complement activation. VBASE3_C_HUMAN_IGHG1_MEM_01 X52847 https://www.ncbi.nlm.nih.gov/nuccore/X52847 data/constant_regions/genbank_records/X52847.gb Homo sapiens Human IGH IGHG1 01 G1m17,1 IgG1 IgG Membrane 400 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV EPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIIPDYRNMIGQGA ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA 231 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG ASTKGPSVFPLAPSS ASTKGPSVFPLAPSSKSTSGGTAALGCLVK Spliced after CH3 residue 445 (SPG); M1 contains 18-aa extracellular spacer + 26-aa TM domain; M2 has 27-aa cytoplasmic signaling tail. IGH: 4/9 (Cgamma1) Human mRNA for membrane-bound immunoglobulin gamma-1 chain. Human mRNA for membrane-bound immunoglobulin gamma-1 chain. Membrane-bound IgG1 BCR. Expressed on memory B cells and plasmablasts following class switch recombination. VBASE3_C_HUMAN_IGHG1_LALA J00228 https://www.ncbi.nlm.nih.gov/nuccore/J00228 data/constant_regions/genbank_records/J00228.gb Homo sapiens Human IGH IGHG1 LALA-PG Effector-Silent IgG1 IgG Engineered 330 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV EPKSCDKTHTCPPCP APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 232 EPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPSS ASTKGPSVFPLAPSSKSTSGGTAALGCLVK Engineered triple mutation: L234A, L235A, and P329G in CH2 completely ablate Fc-gamma receptor and C1q binding. Engineered variant (derived from GenBank J00228 Cgamma1) Engineered derivative of GenBank J00228 with L234A, L235A, P329G mutations. Engineered derivative of GenBank J00228 with L234A, L235A, P329G mutations. Engineered effector-silent Fc standard. Eliminates ADCC, ADCP, and CDC for receptor-blocking therapeutics. VBASE3_C_HUMAN_IGHG2_SEC_01 J00230 https://www.ncbi.nlm.nih.gov/nuccore/J00230 data/constant_regions/genbank_records/J00230.gb Homo sapiens Human IGH IGHG2 01 G2m(..) IgG2 IgG Secreted 326 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTV ERKCCVECPPCP APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 228 ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSESTAALGCLVK CH1 residue 14 (Cys) + residue 18 (Ser); rigid 4-cysteine hinge (ERKCCVECPPCP) forming disulfide isomers A and B. IGH: 6/9 (Cgamma2) Human Ig germline H-chain G-E-A region B: gamma-2 constant region, 3' end. Human Ig germline H-chain G-E-A region B: gamma-2 constant region, 3' end. Secreted IgG2 backbone. Specialized for carbohydrate and bacterial polysaccharide antigens. Panitumumab and Denosumab backbone. VBASE3_C_HUMAN_IGHG2_MEM_01 AB006775 https://www.ncbi.nlm.nih.gov/nuccore/AB006775 data/constant_regions/genbank_records/AB006775.gb Homo sapiens Human IGH IGHG2 01 G2m(..) IgG2 IgG Membrane 396 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTV ERKCCVECPPCP APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFK VKWIFSSVVDLKQTIVPDYRNMIRQGA ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA 227 ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSESTAALGCLVK M1 position 40 carries Ile (ATITFFK) vs Val in IgG1/3 (ATVTFFK); M2 position 23 carries Arg (MIRQGA) vs Gly in IgG1/3 (MIGQGA). IGH: 6/9 (Cgamma2) Homo sapiens gene for membrane-bound form of IgG2 heavy chain, complete cds. Homo sapiens gene for membrane-bound form of IgG2 heavy chain, complete cds. Membrane-bound IgG2 BCR. Expressed on memory B cells responsive to encapsulated bacterial antigens. VBASE3_C_HUMAN_IGHG3_SEC_01 M12886 https://www.ncbi.nlm.nih.gov/nuccore/M12886 data/constant_regions/genbank_records/M12886.gb Homo sapiens Human IGH IGHG3 01 G3m(g) IgG3 IgG Secreted 377 ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRV ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK 279 ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSGGTAALGCLVK 62-amino acid elongated poly-proline hinge (11 interchain disulfides); strongest C1q binding and effector potency among all human IgG subclasses. IGH: 3/9 (Cgamma3) Homo sapiens immunoglobulin heavy chain constant region gamma 3 gene, complete cds. Homo sapiens immunoglobulin heavy chain constant region gamma 3 gene, complete cds. Secreted IgG3 backbone. Highly flexible elongated hinge provides superior neutralization of viruses but shorter serum half-life (7 days). VBASE3_C_HUMAN_IGHG3_MEM_01 D78345 https://www.ncbi.nlm.nih.gov/nuccore/D78345 data/constant_regions/genbank_records/D78345.gb Homo sapiens Human IGH IGHG3 01 G3m(g) IgG3 IgG Membrane 447 ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRV ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPG ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIIPDYRNMIGQGA ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA 278 ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPG ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSGGTAALGCLVK Combines 62-aa extended hinge with transmembrane M1 and cytoplasmic M2 exons. IGH: 3/9 (Cgamma3) Human mRNA for membrane-bound immunoglobulin gamma-3 chain. Human mRNA for membrane-bound immunoglobulin gamma-3 chain. Membrane-bound IgG3 BCR. Participates in early antiviral B-cell memory. VBASE3_C_HUMAN_IGHG4_SEC_01 K01316 https://www.ncbi.nlm.nih.gov/nuccore/K01316 data/constant_regions/genbank_records/K01316.gb Homo sapiens Human IGH IGHG4 01 G4m(a) IgG4 IgG Secreted 327 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV ESKYGPPCPSCP APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 229 ESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSESTAALGCLVK Labile CPSCP core hinge disulfides enable in vivo Fab-arm exchange; poor C1q and Fc-gamma receptor activation. IGH: 7/9 (Cgamma4) Human immunoglobulin heavy chain gamma 4 constant region gene, complete cds. Human immunoglobulin heavy chain gamma 4 constant region gene, complete cds. Wild-type human IgG4 backbone. Undergoes half-antibody exchange in vivo creating bispecific antibodies. VBASE3_C_HUMAN_IGHG4_MEM_01 AL928742 https://www.ncbi.nlm.nih.gov/nuccore/AL928742 data/constant_regions/genbank_records/AL928742.gb Homo sapiens Human IGH IGHG4 01 G4m(a) IgG4 IgG Membrane 397 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV ESKYGPPCPSCP APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIVPDYRNMIRQGA ELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIVPDYRNMIRQGA 228 ESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSESTAALGCLVK Membrane form of IgG4 BCR; M1 spliced after CH3 SLG. IGH: 7/9 (Cgamma4) Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHG4 locus). Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHG4 locus). Membrane-bound IgG4 BCR. Expressed on allergen-tolerant and Th2-skewed memory B cells. VBASE3_C_HUMAN_IGHG4_S228P K01316 https://www.ncbi.nlm.nih.gov/nuccore/K01316 data/constant_regions/genbank_records/K01316.gb Homo sapiens Human IGH IGHG4 S228P Engineered IgG4 IgG Engineered 327 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV ESKYGPPCPPCP APEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 229 ESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK ASTKGPSVFPLAPCS ASTKGPSVFPLAPCSRSTSESTAALGCLVK S228P core hinge mutation (CPPC) prevents intra-chain disulfide isomerism and abolishes in vivo Fab-arm exchange. Engineered variant (derived from GenBank K01316 Cgamma4) Engineered derivative of GenBank K01316 with S228P core hinge stabilizing mutation. Engineered derivative of GenBank K01316 with S228P core hinge stabilizing mutation. Engineered IgG4 therapeutic standard. Backbone of Pembrolizumab (Keytruda) and Nivolumab (Opdivo). VBASE3_C_HUMAN_IGHA1_SEC_01 J00220 https://www.ncbi.nlm.nih.gov/nuccore/J00220 data/constant_regions/genbank_records/J00220.gb Homo sapiens Human IGH IGHA1 01 Native IgA1 IgA Secreted 353 ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPV PSTPPTPSPSTPPTPSPSC CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK PTHVNVSVVMAEVDGTCY 250 PSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY ASPTSPKVFPLSLCS ASPTSPKVFPLSLCSTQPDGNVVIACLVQG N-terminal ASPTSPKVFPLSLC; 19-aa O-glycosylated hinge (PSTPPTPSPSTPPTPSPSC) sensitive to bacterial IgA1 proteases; 18-aa secretory tailpiece. IGH: 5/9 (Calpha1) Homo sapiens immunoglobulin alpha-1 heavy chain constant region (IGHA1) gene. Homo sapiens immunoglobulin alpha-1 heavy chain constant region (IGHA1) gene. Secreted IgA1 monomer (serum) and dimer (mucosa). Tailpiece C-terminal cysteine forms disulfide bonds to J-chain. VBASE3_C_HUMAN_IGHA1_MEM_01 AL928742 https://www.ncbi.nlm.nih.gov/nuccore/AL928742 data/constant_regions/genbank_records/AL928742.gb Homo sapiens Human IGH IGHA1 01 Native IgA1 IgA Membrane 405 ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKSCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPV PSTPPTPSPSTPPTPSPSC CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK SCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSV RGPSGNREGPQY SCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY 232 PSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK ASPTSPKVFPLSLCS ASPTSPKVFPLSLCSTQPDGNVVIACLVQG M1 contains 58-aa extracellular stalk and TM domain; M2 contains 12-aa cytoplasmic tail with RGPSGN motif. IGH: 5/9 (Calpha1) Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA1 locus). Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA1 locus). Membrane-bound IgA1 BCR. Expressed on mucosal-homing B cells and Peyer's patch germinal center B cells. VBASE3_C_HUMAN_IGHA2_SEC_01 J00221 https://www.ncbi.nlm.nih.gov/nuccore/J00221 data/constant_regions/genbank_records/J00221.gb Homo sapiens Human IGH IGHA2 01 A2m(1) IgA2 IgA Secreted 340 ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKPTHINVSVVMAEADGTCY ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPV PPPPPC CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKS GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK PTHINVSVVMAEADGTCY 237 PPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKPTHINVSVVMAEADGTCY ASPSVPKVFPLSLDS ASPSVPKVFPLSLDSTPQDGNVVVACLVQG N-terminal ASPSVPKVFPLSLD (differs from IgA1 at positions 4, 5, 8, 9, 10); short 6-aa hinge lacking O-glycosylation is resistant to bacterial IgA1 proteases. IGH: 9/9 (Calpha2) Human Ig germline H-chain G-E-A region B: alpha-2 A2m(1) allele constant region. Human Ig germline H-chain G-E-A region B: alpha-2 A2m(1) allele constant region. Secreted IgA2. Dominant secretory immunoglobulin in the distal gut and mucosal surfaces colonized by bacteria. VBASE3_C_HUMAN_IGHA2_MEM_01 AL928742 https://www.ncbi.nlm.nih.gov/nuccore/AL928742 data/constant_regions/genbank_records/AL928742.gb Homo sapiens Human IGH IGHA2 01 A2m(1) IgA2 IgA Membrane 392 ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGKSCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY ASPSVPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPV PPPPPC CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKS GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK SCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSV RGPSGKREGPQY SCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY 219 PPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRMAGK ASPSVPKVFPLSLDS ASPSVPKVFPLSLDSTPQDGNVVVACLVQG M1 carries N-terminal SCC (vs SCS in IgA1); M2 has RGPSGK motif (vs RGPSGN in IgA1). IGH: 9/9 (Calpha2) Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA2 locus). Homo sapiens chromosome 14, clone RP11-731F24, complete sequence (IGHA2 locus). Membrane-bound IgA2 BCR. Expressed on gut-associated lymphoid tissue B cells. VBASE3_C_HUMAN_IGHE_SEC_01 J00222 https://www.ncbi.nlm.nih.gov/nuccore/J00222 data/constant_regions/genbank_records/J00222.gb Homo sapiens Human IGH IGHE 01 Native IgE IgE Secreted 428 ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFS VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA DSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTS GPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK 325 VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK ASTQSPSVFPLTRCC ASTQSPSVFPLTRCCKNIPSNATSVTLGCL Four constant domains (CH1-CH4) without hinge; CH2 serves as hinge equivalent; binds Fc-epsilon-RI with sub-nanomolar affinity. IGH: 8/9 (Cepsilon) Human Ig germline H-chain G-E-A region B: epsilon-1 C-region, 3' end. Human Ig germline H-chain G-E-A region B: epsilon-1 C-region, 3' end. Secreted human IgE. Mediates antiparasitic immunity and allergic hypersensitivity. Target of omalizumab (Xolair). VBASE3_C_HUMAN_IGHE_MEM_01 M55420 https://www.ncbi.nlm.nih.gov/nuccore/M55420 data/constant_regions/genbank_records/M55420.gb Homo sapiens Human IGH IGHE 01 Native IgE IgE Membrane 494 ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLMVQRFLSATRQGRPQTSLDYTNVLQPHA ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTWVVDNKTFS VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA DSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTS GPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPG LDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLM VQRFLSATRQGRPQTSLDYTNVLQPHA LDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLMVQRFLSATRQGRPQTSLDYTNVLQPHA 324 VCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPG ASTQSPSVFPLTRCC ASTQSPSVFPLTRCCKNIPSNATSVTLGCL Membrane M1 carries LDVCVEE extracellular spacer + TM domain; M2 has 27-aa cytoplasmic tail. IGH: 8/9 (Cepsilon) Human immunoglobulin epsilon heavy chain membrane-bound form mRNA, complete cds. Human immunoglobulin epsilon heavy chain membrane-bound form mRNA, complete cds. Membrane-bound IgE BCR. Regulates IgE commitment and allergic memory. VBASE3_C_HUMAN_IGKC_01 J00253 https://www.ncbi.nlm.nih.gov/nuccore/J00253 data/constant_regions/genbank_records/J00253.gb Homo sapiens Human IGK IGKC 01 Km(3) IgK Kappa Secreted 107 RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 0 RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC RTVAAPSVFIFPPSD RTVAAPSVFIFPPSDEQLKSGTASVVCLLN N-terminal RTVAAPSVFIFPPSD; Km3 allotype carries Val153 and Leu191 (IMGT numbering); canonical C-terminal Cys forms interchain disulfide to heavy CH1. IGK: 1/1 (Ckappa) Homo sapiens immunoglobulin kappa constant region (IGKC) gene. Homo sapiens immunoglobulin kappa constant region (IGKC) gene. Dominant human kappa light chain constant region. Accounts for ~60% of human antibody light chains. VBASE3_C_HUMAN_IGKC_KM1 J00253 https://www.ncbi.nlm.nih.gov/nuccore/J00253 data/constant_regions/genbank_records/J00253.gb Homo sapiens Human IGK IGKC 02 Km(1) IgK Kappa Secreted 107 RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKAYACEVTHQGLSSPVTKSFNRGEC 0 RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKAYACEVTHQGLSSPVTKSFNRGEC RTVAAPSVFIFPPSD RTVAAPSVFIFPPSDEQLKSGTASVVCLLN Km1 allotype carries Ala153 and Leu191. IGK: 1/1 (Ckappa) Homo sapiens immunoglobulin kappa constant region (IGKC) gene, Km1 allotype. Homo sapiens immunoglobulin kappa constant region (IGKC) gene, Km1 allotype. Human kappa Km1 polymorphic variant. VBASE3_C_HUMAN_IGLC1_01 J00254 https://www.ncbi.nlm.nih.gov/nuccore/J00254 data/constant_regions/genbank_records/J00254.gb Homo sapiens Human IGL IGLC1 01 Mcg+ IgL1 Lambda Secreted 106 GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 0 GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS GQPKANPTVTLFPPS GQPKANPTVTLFPPSSEELQANKATLVCLI N-terminal GQPKANPTVTLFPPS; position 6 has Asn (N), distinguishing IGLC1 from IGLC2/3/6/7 which carry Ala (A). IGL: 1/7 (Clambda1) Homo sapiens immunoglobulin lambda constant region 1 (IGLC1) gene. Homo sapiens immunoglobulin lambda constant region 1 (IGLC1) gene. Human lambda-1 constant region. VBASE3_C_HUMAN_IGLC2_01 J00255 https://www.ncbi.nlm.nih.gov/nuccore/J00255 data/constant_regions/genbank_records/J00255.gb Homo sapiens Human IGL IGLC2 01 Kern- Oz- IgL2 Lambda Secreted 106 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 0 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS GQPKAAPSVTLFPPS GQPKAAPSVTLFPPSSEELQANKATLVCLI N-terminal GQPKAAPSVTLFPPS; position 45 has Ser (S) vs Gly in IGLC1; position 55 has Thr (T) vs Lys in IGLC1. IGL: 2/7 (Clambda2) Homo sapiens immunoglobulin lambda constant region 2 (IGLC2) gene. Homo sapiens immunoglobulin lambda constant region 2 (IGLC2) gene. Most abundant human lambda light chain constant region. Used in Adalimumab-lambda, Dupilumab, etc. VBASE3_C_HUMAN_IGLC3_01 D87017 https://www.ncbi.nlm.nih.gov/nuccore/D87017 data/constant_regions/genbank_records/D87017.gb Homo sapiens Human IGL IGLC3 01 Kern- Oz+ IgL3 Lambda Secreted 106 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS 0 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS GQPKAAPSVTLFPPS GQPKAAPSVTLFPPSSEELQANKATLVCLI Oz+ marker carries Lys at position 100 (HKSYSC) vs Arg in IGLC2 (HRSYSC). IGL: 3/7 (Clambda3) Homo sapiens immunoglobulin lambda gene locus DNA, clone:75C12 (IGLC3). Homo sapiens immunoglobulin lambda gene locus DNA, clone:75C12 (IGLC3). Human lambda-3 constant region. VBASE3_C_HUMAN_IGLC6_01 J03011 https://www.ncbi.nlm.nih.gov/nuccore/J03011 data/constant_regions/genbank_records/J03011.gb Homo sapiens Human IGL IGLC6 01 Kern+ IgL6 Lambda Secreted 106 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVKVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 0 GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVKVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS GQPKAAPSVTLFPPS GQPKAAPSVTLFPPSSEELQANKATLVCLI Position 40 carries Lys (AVKVAW) vs Thr (AVTVAW) in IGLC1/2/3. IGL: 6/7 (Clambda6) Human immunoglobulin lambda-6 light chain gene, complete cds. Human immunoglobulin lambda-6 light chain gene, complete cds. Human lambda-6 constant region. VBASE3_C_HUMAN_IGLC7_01 KM455557 https://www.ncbi.nlm.nih.gov/nuccore/KM455557 data/constant_regions/genbank_records/KM455557.gb Homo sapiens Human IGL IGLC7 01 Native IgL7 Lambda Secreted 106 GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 0 GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS GQPKAAPSVTLFPPS GQPKAAPSVTLFPPSSEELQANKATLVCLV Position 23 has Val (CLVSDF) vs Ile (CLISDF); position 28 has Asn (DFNPG) vs Tyr (DFYPG). IGL: 7/7 (Clambda7) Homo sapiens isolate HPOL3 immunoglobulin lambda constant region 7 (IGLC7) gene. Homo sapiens isolate HPOL3 immunoglobulin lambda constant region 7 (IGLC7) gene. Human lambda-7 constant region. VBASE3_C_HUMAN_TRAC_01 M12959 https://www.ncbi.nlm.nih.gov/nuccore/M12959 data/constant_regions/genbank_records/M12959.gb Homo sapiens Human TRA TRAC 01 Native TCR-Alpha TCR Membrane 140 IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS 0 IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS IQNPDPAVYQLRDSK IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQ N-terminal IQNPDPAVYQLRDSK; invariant single C-alpha gene pairs with all functional TRAV and shared TRAV/TRDV rearrangements. TRA: 1/1 (TRAC) Human T-cell receptor active alpha-chain mRNA from JM cell line, complete cds. Human T-cell receptor active alpha-chain mRNA from JM cell line, complete cds. Human T-cell receptor alpha-chain constant region. Encodes extracellular Ig-like domain, connecting peptide with interchain cysteine, transmembrane, and cytoplasmic tail. VBASE3_C_HUMAN_TRBC1_01 M12887 https://www.ncbi.nlm.nih.gov/nuccore/M12887 data/constant_regions/genbank_records/M12887.gb Homo sapiens Human TRB TRBC1 01 Native TCR-Beta1 TCR Membrane 177 EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF 0 EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF EDLNKVFPPEVAVFE EDLNKVFPPEVAVFEPSEAEISHTQKATLV Position 5: Lys (EDLNKV); position 27: Phe (GFFPD); position 134: Gln (SASYQQ); position 169: Ala; C-terminus: RKDF. TRB: 1/2 (TRBC1) Human T-cell receptor germline beta-chain gene C-region C-beta-1, partial cds. Human T-cell receptor germline beta-chain gene C-region C-beta-1, partial cds. Human TCR beta-chain constant region 1. Linked to TRBD1 and TRBJ1 clusters in tandem genomic cassette. VBASE3_C_HUMAN_TRBC2_01 M12888 https://www.ncbi.nlm.nih.gov/nuccore/M12888 data/constant_regions/genbank_records/M12888.gb Homo sapiens Human TRB TRBC2 01 Native TCR-Beta2 TCR Membrane 177 EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS 0 EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS EDLKNVFPPEVAVFE EDLKNVFPPEVAVFEPSEAEISHTQKATLV Position 5: Asn (EDLKNV); position 27: Tyr (GFYPD); position 134: His (SASYHQ); position 169: Gly; C-terminus: KKNS. TRB: 2/2 (TRBC2) Human T-cell receptor germline beta-chain gene C-region C-beta-2, complete cds. Human T-cell receptor germline beta-chain gene C-region C-beta-2, complete cds. Human TCR beta-chain constant region 2. Linked to TRBD2 and TRBJ2 clusters. Can be utilized by TRBD1/TRBJ1 or TRBD2/TRBJ2 rearrangements. VBASE3_C_HUMAN_TRGC1_01 BC030554 https://www.ncbi.nlm.nih.gov/nuccore/BC030554 data/constant_regions/genbank_records/BC030554.gb Homo sapiens Human TRG TRGC1 01 Native TCR-Gamma1 TCR Membrane 173 DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS 0 DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS DKQLDADVSPKPTIF DKQLDADVSPKPTIFLPSIAETKLQKAGTY N-terminal DKQLDADVSPKPTIF; connects with TRG V-J rearrangements; encodes single connecting peptide exon forming disulfide-linked gammadelta TCR. TRG: 1/2 (TRGC1) Homo sapiens T cell receptor gamma constant 1, mRNA (cDNA clone MGC:46162), complete cds. Homo sapiens T cell receptor gamma constant 1, mRNA (cDNA clone MGC:46162), complete cds. Human TCR gamma-chain constant region 1. Forms disulfide-linked heterodimer with TRDC. VBASE3_C_HUMAN_TRGC2_01 BC017861 https://www.ncbi.nlm.nih.gov/nuccore/BC017861 data/constant_regions/genbank_records/BC017861.gb Homo sapiens Human TRG TRGC2 01 Native TCR-Gamma2 TCR Membrane 173 DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDIIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGIDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS 0 DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDIIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGIDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS DKQLDADVSPKPTIF DKQLDADVSPKPTIFLPSIAETKLQKAGTY Position 33: Ile (IIKIHW) vs Val in TRGC1; position 82: Ile (GIDQEI) vs Val in TRGC1; often forms non-disulfide-linked gammadelta TCR. TRG: 2/2 (TRGC2) Homo sapiens TCR gamma alternate reading frame protein, mRNA (cDNA clone MGC:22026), complete cds. Homo sapiens TCR gamma alternate reading frame protein, mRNA (cDNA clone MGC:22026), complete cds. Human TCR gamma-chain constant region 2. Often associated with non-disulfide linked gamma-delta TCR forms. VBASE3_C_HUMAN_TRDC_01 M21624 https://www.ncbi.nlm.nih.gov/nuccore/M21624 data/constant_regions/genbank_records/M21624.gb Homo sapiens Human TRD TRDC 01 Native TCR-Delta TCR Membrane 153 SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL 0 SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL SQPHTKPSVFVMKNG SQPHTKPSVFVMKNGTNVACLVKEFYPKDI N-terminal SQPHTKPSVFVMKNG; single C-delta gene located within the TRA locus between TRAV and TRAJ. TRD: 1/1 (TRDC) Human T-cell receptor delta chain mRNA (VJC-region), complete cds. Human T-cell receptor delta chain mRNA (VJC-region), complete cds. Human TCR delta-chain constant region. Pairs with TRGC to form gammadelta T-cell receptor. VBASE3_C_MOUSE_IGHM_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighm 01 129S1 (Igh-6a) IgM IgM Secreted 473 ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCY GKPTLYNVSLIMSDTGGTCY 368 AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY ESQSFPNVFPLVSCE ESQSFPNVFPLVSCESPLSDKNLVAMGCLA N-terminal ESQSFPNVFPLVSCE distinguishes IgM from other isotypes; tailpiece contains Cys575 for J-chain incorporation. IGH: 1/8 (Cmu) Mus musculus Ig heavy chain locus constant region, strain 129S1 (Retter et al. 2007). Mus musculus Ig heavy chain locus constant region, strain 129S1 (Retter et al. 2007). Secreted pentameric/hexameric IgM heavy chain from strain 129S1. Terminal Cys575 forms disulfide link to J-chain. VBASE3_C_MOUSE_IGHM_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighm 01 129S1 (Igh-6a) IgM IgM Membrane 474 ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTEGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKST EGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK VK EGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK 328 AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKST ESQSFPNVFPLVSCE ESQSFPNVFPLVSCESPLSDKNLVAMGCLA Alternative splicing after CH4 residue 555 joins to M1/M2 exons; short KVK cytoplasmic tail interacts with CD79a/CD79b. IGH: 1/8 (Cmu) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00444). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00444). Membrane-bound B-cell receptor (BCR) IgM monomer from 129S1. Forms functional BCR complex non-covalently with CD79a/CD79b. VBASE3_C_MOUSE_IGHD_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighd 01 129S1 (Igh-5a) IgD IgD Secreted 299 DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFPSWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPLDATTSCLSQTVLPGDLMVLPL DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFP SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIE AMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPL DATTSCLSQTVLPGDLMVLPL 190 SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSDATTSCLSQTVLPGDLMVLPLDATTSCLSQTVLPGDLMVLPL DKKEPDMFLLSECKA DKKEPDMFLLSECKAPEENEKINLGCLVIG N-terminal DKKEPDMFLLSECKA; contains elongated flexible hinge and secretory tailpiece. IGH: 2/8 (Cdelta) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00448). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00448). Secreted murine serum IgD from strain 129S1. Produced in trace amounts via differential alternative polyadenylation. VBASE3_C_MOUSE_IGHD_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighd 01 129S1 (Igh-5a) IgD IgD Membrane 314 DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFPSWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPSIVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIKVK DKKEPDMFLLSECKAPEENEKINLGCLVIGSQPLKISFTWTRQNKHLESGVPTLPTVLSTGTYSLSSTLTLSVADWERGAVYTCSVTHPALSSPVIKSLKRKEKPFKFP SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIE AMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPS IVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIK VK IVNTIQHSCIMDEQSDSYMDLEEENGGCLQTNTLSTFLALFISTLLYSGFVTFIKVK 148 SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLVDGKEVTNVVQGKEQTVSNKMKTMASMSTYKVTTTLTITKSNWLKSNVYTCQVEHRGLKTLKNTSTSCAMSPS DKKEPDMFLLSECKA DKKEPDMFLLSECKAPEENEKINLGCLVIG Spliced after CH3 to 52-aa extracellular stalk/TM exon (M1) and short cytoplasmic VK tail (M2). IGH: 2/8 (Cdelta) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00450). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00450). Membrane-bound IgD BCR from strain 129S1. Co-expressed with membrane IgM on naive follicular mature B cells. VBASE3_C_MOUSE_IGHG3_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg3 01 129S1 (Igh-8a) IgG3 IgG Secreted 330 ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI EPRIPKPSTPPGSSCP PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK 233 EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK ATTTAPSVYPLVPGC ATTTAPSVYPLVPGCSDTSGSSVTLGCLVK N-terminal ATTTAPSVYPLVPGC; characteristic 15-aa proline-rich hinge. IGH: 3/8 (Cgamma3) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451). Secreted murine IgG3 heavy chain from 129S1. Self-associates via Fc-Fc contacts; primary response against carbohydrate antigens. VBASE3_C_MOUSE_IGHG3_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg3 01 129S1 (Igh-8a) IgG3 IgG Membrane 398 ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPLELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVQVKQTAIPDYRNMIGQGA ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI EPRIPKPSTPPGSSCP PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSP LELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK VKWIFSSVVQVKQTAIPDYRNMIGQGA LELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVQVKQTAIPDYRNMIGQGA 231 EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSP ATTTAPSVYPLVPGC ATTTAPSVYPLVPGCSDTSGSSVTLGCLVK Spliced after CH3 to 44-aa M1 TM domain and 27-aa cytoplasmic signaling tail. IGH: 3/8 (Cgamma3) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / D78343). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / D78343). Membrane-bound IgG3 BCR monomer from strain 129S1. VBASE3_C_MOUSE_IGHG1_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg1 01 129S1 (Igh-4a) IgG1 IgG Secreted 324 AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI VPRDCGCKPCI CTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK 227 VPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK AKTTPPSVYPLAPGS AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK N-terminal AKTTPPSVYPLAPGS; canonical mouse Th2-switched subclass. IGH: 4/8 (Cgamma1) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00443). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00443). Secreted murine IgG1 heavy chain from 129S1. Dominant antibody in Th2-mediated responses; binds FcγRIII. VBASE3_C_MOUSE_IGHG1_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg1 01 129S1 (Igh-4a) IgG1 IgG Membrane 391 AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPLQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFKVKWIFSSVVELKQTLVPEYKNMIGQAP AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI VPRDCGCKPCI CTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSP LQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFK VKWIFSSVVELKQTLVPEYKNMIGQAP LQLDETCAEAQDGELDGLWTTITIFISLFLLSCYSAAVTLFKVKWIFSSVVELKQTLVPEYKNMIGQAP 225 VPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSP AKTTPPSVYPLAPGS AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK Spliced after CH3 residue 448 to 43-aa M1 TM exon and 27-aa cytoplasmic signaling tail (M2). IGH: 4/8 (Cgamma1) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00454). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00454). Membrane-bound IgG1 BCR monomer from strain 129S1. VBASE3_C_MOUSE_IGHG2B_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg2b 01 129S1 (Igh-3a) IgG2b IgG Secreted 336 AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL EPSGPISTINPCPPCKECHKCP APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK 239 EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK AKTTPPSVYPLAPGC AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK N-terminal AKTTPPSVYPLAPGC; potent FcγRIV engagement. IGH: 5/8 (Cgamma2b) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00445). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00445). Secreted murine IgG2b heavy chain from 129S1. High affinity for mouse FcγRIV; widely utilized in target-depleting monoclonal antibodies. VBASE3_C_MOUSE_IGHG2B_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg2b 01 129S1 (Igh-3a) IgG2b IgG Membrane 404 AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL EPSGPISTINPCPPCKECHKCP APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSP LDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFK VKWIFSSVVELKQKISPDYRNMIGQGA LDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA 237 EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSP AKTTPPSVYPLAPGC AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK Spliced after CH3 to 44-aa M1 TM domain and 27-aa cytoplasmic signaling tail. IGH: 5/8 (Cgamma2b) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00462). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00462). Membrane-bound IgG2b BCR monomer from strain 129S1. VBASE3_C_MOUSE_IGHG2A_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg2a 01 129S1 / BALB/c (Igh-1a) IgG2a IgG Secreted 330 AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI EPRGPTIKPCPPCKCP APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 233 EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK AKTTAPSVYPLAPVC AKTTAPSVYPLAPVCGDTTGSSVTLGCLVK N-terminal AKTTAPSVYPLAPVC with APVCGD motif; authentic Igh-1a allotype present in 129 and BALB/c (absent in C57BL/6). IGH: 6/8 (Cgamma2a) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00444). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00444). Secreted murine IgG2a heavy chain. Potent complement fixation and ADCC; replaced by IgG2c in C57BL/6 mice. VBASE3_C_MOUSE_IGHG2A_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighg2a 01 129S1 / BALB/c (Igh-1a) IgG2a IgG Membrane 398 AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI EPRGPTIKPCPPCKCP APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK VKWIFSSVVELKQTISPDYRNMIGQGA LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA 231 EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP AKTTAPSVYPLAPVC AKTTAPSVYPLAPVCGDTTGSSVTLGCLVK Spliced after CH3 residue 448 to 44-aa M1 TM domain and 27-aa cytoplasmic tail. IGH: 6/8 (Cgamma2a) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00471). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / J00471). Membrane-bound IgG2a BCR monomer from 129S1 / BALB/c. VBASE3_C_MOUSE_IGHE_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighe 01 129S1 (Igh-7a) IgE IgE Secreted 465 SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPCNIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCYGKPTLYNVSLVMSDTAGTCY SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPC NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPK ELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGK GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY GKPTLYNVSLVMSDTAGTCY 369 NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCYGKPTLYNVSLVMSDTAGTCY SIRNPQLYPLKPCKG SIRNPQLYPLKPCKGTASMTLGCLVKDYFP N-terminal SIRNPQLYPLKPC; 4-domain CH1-CH4 architecture lacking distinct genetic hinge. IGH: 7/8 (Cepsilon) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00451). Secreted murine IgE heavy chain from 129S1. High-affinity binder to mouse FcεRI on mast cells and basophils. VBASE3_C_MOUSE_IGHE_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Ighe 01 129S1 (Igh-7a) IgE IgE Membrane 494 SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPCNIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKSTLQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQTSMSGTWAKASTFTCEVTHTQPSTLKTITKCPPC NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPK ELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGK GVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKST LQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFK VKWIFSSVVELKQTISPDYRNMIGQGA LQLETCAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA 329 NIPCPVPEEVGGPVIFFPPKPKDVLMISLTPKVTCVVVDVSKDDPDVQISWFVDGKQVTETENAPTLIQEIRTHSVLPIQHQDWLNGKKFKCKVNNKTLPSPVDRTINKPKELPQKPAVFLLPPPEEELKRDTTLTCMISDFFPEDVSVQWKWNGDTGNTLKMKVTVEKTQDTGSYFLYSKLSVETDEWKSGDTFSCVVLHEALHNYHTQKSINKSLGKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTERTVDKST SIRNPQLYPLKPCKG SIRNPQLYPLKPCKGTASMTLGCLVKDYFP Spliced after CH4 to M1 TM stalk and cytoplasmic signaling tail (M2). IGH: 7/8 (Cepsilon) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / X03624). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / X03624). Membrane-bound IgE BCR monomer from strain 129S1. VBASE3_C_MOUSE_IGHA_01 AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Igha 01 129S1 (Igh-2) IgA IgA Secreted 362 SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSGPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS GPTPPPPITIP SCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT NTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICY GKPTNVSVSVIMSEGDGICY 262 GPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY SARNPTIYPLTLPPA SARNPTIYPLTLPPALSSDPVIIGCLIHDY N-terminal SARNPTIYPLTLPP distinguishes 129/C57 IgA from BALB/c IgA (which starts with EDLNPRVFPLSLCT). IGH: 8/8 (Calpha) Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00475). Mus musculus Ig heavy chain locus constant region, strain 129S1 (AJ851868 / J00475). Secreted murine dimeric/polymeric mucosal IgA from strain 129S1. Terminal Cys495 links to J-chain. VBASE3_C_MOUSE_IGHA_01_MEMBRANE AJ851868 https://www.ncbi.nlm.nih.gov/nuccore/AJ851868 data/constant_regions/genbank_records/AJ851868.gb Mus musculus Mouse IGH Igha 01 129S1 (Igh-2) IgA IgA Membrane 322 SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSGPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS SARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS GPTPPPPITIP SCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT NTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS 222 GPTPPPPITIPSCQPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLS SARNPTIYPLTLPPA SARNPTIYPLTLPPALSSDPVIIGCLIHDY Spliced after CH3 residue 445 to 64-aa CH-M transmembrane and cytoplasmic signaling tail. IGH: 8/8 (Calpha) Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / K00691). Mus musculus Ig heavy chain locus constant region, strain 129S1: membrane exons (AJ851868 / K00691). Membrane-bound IgA BCR monomer from strain 129S1. VBASE3_C_MOUSE_IGHM_C57BL6 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighm 04 C57BL/6 (Igh-6b) IgM IgM Secreted 473 ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY ESQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIP AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAA PSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPN VHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCY GKPTLYNVSLIMSDTGGTCY 368 AVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAAPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCYGKPTLYNVSLIMSDTGGTCY ESQSFPNVFPLVSCE ESQSFPNVFPLVSCESPLSDKNLVAMGCLA N-terminal ESQSFPNVFPLVSCE; C57BL/6 Igh-6b allotype. IGH: 1/8 (Cmu) Mus musculus C57BL/6 chromosome 12 IGH locus: Cmu gene (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Cmu gene (BK063712). Secreted IgM heavy chain from C57BL/6. VBASE3_C_MOUSE_IGHG1_C57BL6 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighg1 02 C57BL/6 (Igh-4b) IgG1 IgG Secreted 324 AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTCPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI VPRDCGCKPCICT CPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK 227 VPRDCGCKPCICTCPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK AKTTPPSVYPLAPGS AKTTPPSVYPLAPGSAAQTNSMVTLGCLVK N-terminal AKTTPPSVYPLAPGS; C57BL/6 Igh-4b allotype. IGH: 4/8 (Cgamma1) Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma1 gene (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma1 gene (BK063712). Secreted IgG1 heavy chain from C57BL/6. VBASE3_C_MOUSE_IGHG2B_C57BL6 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighg2b 03 C57BL/6 (Igh-3b) IgG2b IgG Secreted 336 AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK AKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKL EPSGPISTINPCPPCKECHKCP APNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK 239 EPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK AKTTPPSVYPLAPGC AKTTPPSVYPLAPGCGDTTGSSVTLGCLVK N-terminal AKTTPPSVYPLAPGC; C57BL/6 Igh-3b allotype. IGH: 5/8 (Cgamma2b) Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2b gene (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2b gene (BK063712). Secreted IgG2b heavy chain from C57BL/6. VBASE3_C_MOUSE_IGHG2C_01 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighg2c 03 C57BL/6 (Igh-1b) IgG2c IgG Secreted 330 AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI EPRGPTIKPCPPCKCP APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 233 EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK AKTTAPSVYPLAPVC AKTTAPSVYPLAPVCGGTTGSSVTLGCLVK N-terminal AKTTAPSVYPLAPVC with APVCGG motif; authentic C57BL/6 Igh-1b product replacing IgG2a. IGH: 6/8 (Cgamma2c) Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c gene (BK063712 / AB097847). Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c gene (BK063712 / AB097847). Secreted murine IgG2c heavy chain. The authentic C57BL/6 isotype (Igh-1b allele). C57BL/6 mice lack the Ighg2a gene. VBASE3_C_MOUSE_IGHG2C_01_MEMBRANE BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighg2c 03 C57BL/6 (Igh-1b) IgG2c IgG Membrane 398 AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA AKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI EPRGPTIKPCPPCKCP APNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPK GSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK VKWIFSSVVELKQTISPDYRNMIGQGA LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA 231 EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTP AKTTAPSVYPLAPVC AKTTAPSVYPLAPVCGGTTGSSVTLGCLVK Spliced after CH3 residue 448 to 44-aa M1 TM domain and 27-aa cytoplasmic tail. IGH: 6/8 (Cgamma2c) Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c membrane exons (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma2c membrane exons (BK063712). Membrane-bound IgG2c BCR monomer from C57BL/6. VBASE3_C_MOUSE_IGHG3_C57BL6 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Ighg3 03 C57BL/6 (Igh-8b) IgG3 IgG Secreted 330 ATTTAPSVYPLVPGCGDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRIEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK ATTTAPSVYPLVPGCGDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSSVLQSGFYSLSSLVTVPSSTWPSQTVICNVAHPASKTELIKRI EPRIPKPSTPPGSSCP PGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPK GRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK 233 EPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLSVETDTWLMENVFTCSVIHEALHNHHTQKNLSRSPGK ATTTAPSVYPLVPGC ATTTAPSVYPLVPGCGDTSGSSVTLGCLVK N-terminal ATTTAPSVYPLVPGC with PGCGDTS motif; C57BL/6 Igh-8b allotype. IGH: 3/8 (Cgamma3) Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma3 gene (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Cgamma3 gene (BK063712). Secreted IgG3 heavy chain from C57BL/6. VBASE3_C_MOUSE_IGHA_C57BL6 BK063712 https://www.ncbi.nlm.nih.gov/nuccore/BK063712 data/constant_regions/genbank_records/BK063712.gb Mus musculus Mouse IGH Igha 09 C57BL/6 (Igh-2b) IgA IgA Secreted 364 ESARNPTIYPLTLPRALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCSPPPPPCPPCPPSCHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY ESARNPTIYPLTLPRALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQELDVNCS PPPPPCPPCPPS CHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVT NNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICY GKPTNVSVSVIMSEGDGICY 263 PPPPPCPPCPPSCHPSLSLQRPALEDLLLGSDASITCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESGTLTGTIAKVTNNTFPPQVHLLPPPSEELALNELLSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAETWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICYGKPTNVSVSVIMSEGDGICY ESARNPTIYPLTLPR ESARNPTIYPLTLPRALSSDPVIIGCLIHD N-terminal ESARNPTIYPLTLPR; C57BL/6 Igh-2b allotype. IGH: 8/8 (Calpha) Mus musculus C57BL/6 chromosome 12 IGH locus: Calpha gene (BK063712). Mus musculus C57BL/6 chromosome 12 IGH locus: Calpha gene (BK063712). Secreted IgA heavy chain from C57BL/6. VBASE3_C_MOUSE_IGHA_BALBC J00449 https://www.ncbi.nlm.nih.gov/nuccore/J00449 data/constant_regions/genbank_records/J00449.gb Mus musculus Mouse IGH Igha 02 BALB/c (Igh-2a) IgA IgA Secreted 374 EDLNPRVFPLSLCTTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCYLAGKPTHVNVSVVMAEVDGTCY EDLNPRVFPLSLCTTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVP CPVPSTPPTPSPSTPPTPSPSC CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKS GNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY LAGKPTHVNVSVVMAEVDGTCY 275 CPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCYLAGKPTHVNVSVVMAEVDGTCY EDLNPRVFPLSLCTT EDLNPRVFPLSLCTTQPDGNVVIACLVQGF N-terminal EDLNPRVFPLSLCTT; BALB/c Igh-2a allotype with characteristic proline-rich hinge. IGH: 8/8 (Calpha) Mouse germline IgA chain gene, complete cds (BALB/c strain J00449). Mouse germline IgA chain gene, complete cds (BALB/c strain J00449). Secreted BALB/c IgA heavy chain. Forms dimeric secretory IgA (sIgA) across mucosal surfaces. VBASE3_C_MOUSE_IGKC_01 V00807 https://www.ncbi.nlm.nih.gov/nuccore/V00807 data/constant_regions/genbank_records/V00807.gb Mus musculus Mouse IGK Igkc 01 Standard (129 / BALB/c) IgK Kappa Secreted 107 RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 0 RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC RADAAPTVSIFPPSS RADAAPTVSIFPPSSEQLTSGGASVVCFLN N-terminal RADAAPTVSIFPPS; invariant C-terminal Cys214 pairs with heavy chain CH1 Cys. IGK: 1/1 (Ckappa) Part of the germ line murine gene for kappa-immunoglobulin (V00807). Part of the germ line murine gene for kappa-immunoglobulin (V00807). Pairs with >95% of all expressed murine antibody variable heavy domains. VBASE3_C_MOUSE_IGKC_02 AJ487682 https://www.ncbi.nlm.nih.gov/nuccore/AJ487682 data/constant_regions/genbank_records/AJ487682.gb Mus musculus Mouse IGK Igkc 02 C57BL/6 IgK Kappa Secreted 107 RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 0 RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC RADAAPTVSIFPPSS RADAAPTVSIFPPSSEQLTSGGASVVCFLN N-terminal RADAAPTVSIFPPS. IGK: 1/1 (Ckappa) Mus musculus IGKC gene for immunoglobulin kappa light chain, strain C57BL/6 (AJ487682). Mus musculus IGKC gene for immunoglobulin kappa light chain, strain C57BL/6 (AJ487682). C57BL/6 mouse kappa constant region allele. VBASE3_C_MOUSE_IGLC1_01 BC119451 https://www.ncbi.nlm.nih.gov/nuccore/BC119451 data/constant_regions/genbank_records/BC119451.gb Mus musculus Mouse IGL Iglc1 01 Standard IgL1 Lambda Secreted 106 GQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS 0 GQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS GQPKSSPSVTLFPPS GQPKSSPSVTLFPPSSEELETNKATLVCTI N-terminal GQPKSSPSVTLFPPS; primary mouse lambda isotype (~80% of rare mouse lambda chains). IGL: Tandem Cassette 1 (J1-C1) Mus musculus immunoglobulin lambda chain, variable 1, mRNA (cDNA clone BC119451). Mus musculus immunoglobulin lambda chain, variable 1, mRNA (cDNA clone BC119451). Primary mouse lambda light chain constant region. Rearranges preferentially with Vlambda1. VBASE3_C_MOUSE_IGLC2_01 IMGT000117 https://www.ncbi.nlm.nih.gov/nuccore/IMGT000117 data/constant_regions/genbank_records/IMGT000117.gb Mus musculus Mouse IGL Iglc2 01 Standard IgL2 Lambda Secreted 105 GQPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL 0 GQPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL GQPKSTPTLTVFPPS GQPKSTPTLTVFPPSSEELKENKATLVCLI N-terminal GQPKSTPTLTVFPPS. IGL: Tandem Cassette 2 (J2-C2) Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 2. Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 2. Mouse lambda-2 constant region. Rearranges preferentially with Vlambda2. VBASE3_C_MOUSE_IGLC3_01 IMGT000117 https://www.ncbi.nlm.nih.gov/nuccore/IMGT000117 data/constant_regions/genbank_records/IMGT000117.gb Mus musculus Mouse IGL Iglc3 01 Standard IgL3 Lambda Secreted 105 GQPKSTPTLTMFPPSPEELQENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEDNKYMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL 0 GQPKSTPTLTMFPPSPEELQENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEDNKYMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL GQPKSTPTLTMFPPS GQPKSTPTLTMFPPSPEELQENKATLVCLI N-terminal GQPKSTPTLTMFPPS; distinguished by Met9 in tag. IGL: Tandem Cassette 3 (J3-C3) Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 3. Mus musculus strain C57BL/6J assembly GRCm39 lambda constant gene 3. Mouse lambda-3 constant region. Rearranges preferentially with Vlambda1. VBASE3_C_MOUSE_TRAC_01 M14506 https://www.ncbi.nlm.nih.gov/nuccore/M14506 data/constant_regions/genbank_records/M14506.gb Mus musculus Mouse TRA Trac 01 Standard TRAC TCR Membrane 137 DIQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNGAIAWSNQTSFTCQDIFKETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLRILLLKVAGFNLLMTLRLWSS 0 DIQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNGAIAWSNQTSFTCQDIFKETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLRILLLKVAGFNLLMTLRLWSS DIQNPEPAVYQLKDP DIQNPEPAVYQLKDPRSQDSTLCLFTDFDS N-terminal DIQNPEPAVYQLKDP; pairs with TRBC beta chain in alpha/beta TCR. TRA: 1/1 (Calpha) Mouse T-cell receptor active alpha-chain mRNA from hybridoma T-s 34S-281 (M14506). Mouse T-cell receptor active alpha-chain mRNA from hybridoma T-s 34S-281 (M14506). Mouse TCR alpha chain constant domain. Extracellular immunoglobulin domain, connecting peptide with interchain cysteine, TM and cytoplasmic tail. VBASE3_C_MOUSE_TRBC1_01 AE000665 https://www.ncbi.nlm.nih.gov/nuccore/AE000665 data/constant_regions/genbank_records/AE000665.gb Mus musculus Mouse TRB Trbc1 01 Standard TRBC1 TCR Membrane 172 EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKNS 0 EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKNS EDLRNVTPPKVSLFE EDLRNVTPPKVSLFEPSKAEIANKQKATLV N-terminal EDLRNVTPPKVSLFE; distinguished from TRBC2 by SYQQ (residues 133-136), SALV (163-166), and VKRK (173-176). TRB: Tandem Cassette 1 (Dbeta1-Jbeta1-Cbeta1) Mus musculus TCR beta locus: Cbeta1 constant gene (AE000665 / IMGT000132). Mus musculus TCR beta locus: Cbeta1 constant gene (AE000665 / IMGT000132). Mouse TCR beta constant domain 1. Part of the first tandem cassette (Dbeta1-Jbeta1-Cbeta1); used exclusively by Jbeta1 cluster joins. VBASE3_C_MOUSE_TRBC2_01 AE000665 https://www.ncbi.nlm.nih.gov/nuccore/AE000665 data/constant_regions/genbank_records/AE000665.gb Mus musculus Mouse TRB Trbc2 03 Standard TRBC2 TCR Membrane 172 EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS 0 EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSSYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS EDLRNVTPPKVSLFE EDLRNVTPPKVSLFEPSKAEIANKQKATLV N-terminal EDLRNVTPPKVSLFE; distinguished from TRBC1 by SYHQ (residues 133-136), SGLV (163-166), and VKKK (173-176). TRB: Tandem Cassette 2 (Dbeta2-Jbeta2-Cbeta2) Mus musculus TCR beta locus: Cbeta2 constant gene (AE000665 / IMGT000132). Mus musculus TCR beta locus: Cbeta2 constant gene (AE000665 / IMGT000132). Mouse TCR beta constant domain 2. Part of the second tandem cassette (Dbeta2-Jbeta2-Cbeta2); used by Jbeta2 cluster joins. VBASE3_C_MOUSE_TRGC1_01 AF037352 https://www.ncbi.nlm.nih.gov/nuccore/AF037352 data/constant_regions/genbank_records/AF037352.gb Mus musculus Mouse TRG Trgc1 01 Standard TRGC1 TCR Membrane 109 KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKDGNTILDSQEGDTLKTNDTYMKFSWLTVPERAMGKEHRCIVKHENNKGGADQEIFFPSIKK 0 KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKDGNTILDSQEGDTLKTNDTYMKFSWLTVPERAMGKEHRCIVKHENNKGGADQEIFFPSIKK KRLDADISPKPTIFL KRLDADISPKPTIFLPSVAETNLHKTGTYL N-terminal KRLDADISPKPTIFL. TRG: Cassette 1 (Jgamma1-Cgamma1) Mus musculus T cell receptor gamma locus: Cgamma1 gene (AF037352). Mus musculus T cell receptor gamma locus: Cgamma1 gene (AF037352). Mouse TCR gamma constant domain 1. Expressed on canonical intraepithelial and dermal gamma/delta T cells. VBASE3_C_MOUSE_TRGC2_01 AF021335 https://www.ncbi.nlm.nih.gov/nuccore/AF021335 data/constant_regions/genbank_records/AF021335.gb Mus musculus Mouse TRG Trgc2 01 Standard TRGC2 TCR Membrane 109 KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKNGNTILDSQEGDTLKTKGTYMKFSWLTVPERAMGKEHSCIVKHENNKGGADQEIFFPSIKK 0 KRLDADISPKPTIFLPSVAETNLHKTGTYLCLLEKFFPDVIRVYWKEKNGNTILDSQEGDTLKTKGTYMKFSWLTVPERAMGKEHSCIVKHENNKGGADQEIFFPSIKK KRLDADISPKPTIFL KRLDADISPKPTIFLPSVAETNLHKTGTYL N-terminal KRLDADISPKPTIFL; distinguished by Asn50 and Ser84. TRG: Cassette 2 (Jgamma2-Cgamma2) Mus musculus T cell receptor gamma locus: Cgamma2 gene (AF021335). Mus musculus T cell receptor gamma locus: Cgamma2 gene (AF021335). Mouse TCR gamma constant domain 2. VBASE3_C_MOUSE_TRGC4_01 AF021335 https://www.ncbi.nlm.nih.gov/nuccore/AF021335 data/constant_regions/genbank_records/AF021335.gb Mus musculus Mouse TRG Trgc4 01 Standard TRGC4 TCR Membrane 109 KRTDSDFSPKPTIFLPSAAETNLHKAGTYLCLLEKFFPEVIRVYWKEKDGEKILESQEGNTIKTNDRYMKFSWLTVTEDSMAKEHSCIVKHENNKRGVDQEILFPPIGK 0 KRTDSDFSPKPTIFLPSAAETNLHKAGTYLCLLEKFFPEVIRVYWKEKDGEKILESQEGNTIKTNDRYMKFSWLTVTEDSMAKEHSCIVKHENNKRGVDQEILFPPIGK KRTDSDFSPKPTIFL KRTDSDFSPKPTIFLPSAAETNLHKAGTYL N-terminal KRTDSDFSPKPTIFL; distinguished by KRTDS and AAETN. TRG: Cassette 4 (Jgamma4-Cgamma4) Mus musculus T cell receptor gamma locus: Cgamma4 gene (AF021335). Mus musculus T cell receptor gamma locus: Cgamma4 gene (AF021335). Mouse TCR gamma constant domain 4. VBASE3_C_MOUSE_TRDC_01 AE007512 https://www.ncbi.nlm.nih.gov/nuccore/AE007512 data/constant_regions/genbank_records/AE007512.gb Mus musculus Mouse TRD Trdc 01 Standard TRDC TCR Membrane 92 SQPPAKPSVFIMKNGTNVACLVKDFYPKEVTISLRSSKKIVEFDPAIVISPSGKYSAVKLGQYGDSNSVTCSVQHNSETVHSTDFEPYANSF 0 SQPPAKPSVFIMKNGTNVACLVKDFYPKEVTISLRSSKKIVEFDPAIVISPSGKYSAVKLGQYGDSNSVTCSVQHNSETVHSTDFEPYANSF SQPPAKPSVFIMKNG SQPPAKPSVFIMKNGTNVACLVKDFYPKEV N-terminal SQPPAKPSVFIMKNG; pairs with TRGC gamma chain in gamma/delta TCR. TRD: 1/1 (Cdelta) Mus musculus T-cell receptor alpha/delta locus, complete sequence (AE007512). Mus musculus T-cell receptor alpha/delta locus, complete sequence (AE007512). Mouse TCR delta constant domain. VBASE3_C_CANINE_IGHG_A_01 AF354264 https://www.ncbi.nlm.nih.gov/nuccore/AF354264 data/constant_regions/genbank_records/AF354264.gb Canis lupus familiaris Dog IGH Ighg-a 01 Standard IgG-A IgG Secreted 331 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKP VFNECRCTDTPPCP VPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARG RAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK 234 VFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS N-terminal ASTTAPSVFPLAPSC with PASNTKVDKP and VFNECRCTDTPPCP hinge; low effector function (Bedinvetmab format). IGH: Cgamma-A Canis familiaris immunoglobulin gamma heavy chain A mRNA, complete cds (AF354264). Canis familiaris immunoglobulin gamma heavy chain A mRNA, complete cds (AF354264). Secreted canine IgG-A heavy chain. Naturally low effector function, ideal for receptor antagonists. VBASE3_C_CANINE_IGHG_A_MEM_01 AF354264 https://www.ncbi.nlm.nih.gov/nuccore/AF354264 data/constant_regions/genbank_records/AF354264.gb Canis lupus familiaris Dog IGH Ighg-a 01 Standard IgG-A IgG Membrane 362 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKP VFNECRCTDTPPCP VPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARG RAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSP ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK VK ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK 232 VFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSP ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS Canine membrane BCR IgG-A; M1 transmembrane domain and short cytoplasmic VK signaling tail. IGH: Cgamma-A Canis familiaris immunoglobulin gamma heavy chain A mRNA, membrane spliced form (AF354264). Canis familiaris immunoglobulin gamma heavy chain A mRNA, membrane spliced form (AF354264). Membrane-bound canine IgG-A BCR monomer. VBASE3_C_CANINE_IGHG_B_01 AF354265 https://www.ncbi.nlm.nih.gov/nuccore/AF354265 data/constant_regions/genbank_records/AF354265.gb Canis lupus familiaris Dog IGH Ighg-b 01 Standard IgG-B IgG Secreted 335 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKP VPKRENGRVPRPPDCPKCP APEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARG QAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK 238 VPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS N-terminal ASTTAPSVFPLAPSC with PASKTKVDKP and VPKRENGR hinge; potent ADCC/CDC effector function (Lokivetmab format). IGH: Cgamma-B Canis familiaris immunoglobulin gamma heavy chain B mRNA, complete cds (AF354265). Canis familiaris immunoglobulin gamma heavy chain B mRNA, complete cds (AF354265). Secreted canine IgG-B heavy chain. The primary effector workhorse in canine therapeutic monoclonal antibodies. VBASE3_C_CANINE_IGHG_B_MEM_01 AF354265 https://www.ncbi.nlm.nih.gov/nuccore/AF354265 data/constant_regions/genbank_records/AF354265.gb Canis lupus familiaris Dog IGH Ighg-b 01 Standard IgG-B IgG Membrane 366 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKP VPKRENGRVPRPPDCPKCP APEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARG QAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSP ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK VK ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK 236 VPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSP ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS Canine membrane BCR IgG-B; M1 transmembrane domain and cytoplasmic VK signaling tail. IGH: Cgamma-B Canis familiaris immunoglobulin gamma heavy chain B mRNA, membrane spliced form (AF354265). Canis familiaris immunoglobulin gamma heavy chain B mRNA, membrane spliced form (AF354265). Membrane-bound canine IgG-B BCR monomer. VBASE3_C_CANINE_IGHG_C_01 AF354266 https://www.ncbi.nlm.nih.gov/nuccore/AF354266 data/constant_regions/genbank_records/AF354266.gb Canis lupus familiaris Dog IGH Ighg-c 01 Standard IgG-C IgG Secreted 333 ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKPVAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKP VAKECECKCNCNNCPCP GCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTP GQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK 236 VAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSQSGSTVALACLVS N-terminal ASTTAPSVFPLAPSCGSQSG with VAKECECK hinge; intermediate canine IgG subclass. IGH: Cgamma-C Canis familiaris immunoglobulin gamma heavy chain C mRNA, complete cds (AF354266). Canis familiaris immunoglobulin gamma heavy chain C mRNA, complete cds (AF354266). Secreted canine IgG-C heavy chain. VBASE3_C_CANINE_IGHG_C_MEM_01 AF354266 https://www.ncbi.nlm.nih.gov/nuccore/AF354266 data/constant_regions/genbank_records/AF354266.gb Canis lupus familiaris Dog IGH Ighg-c 01 Standard IgG-C IgG Membrane 364 ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKPVAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK ASTTAPSVFPLAPSCGSQSGSTVALACLVSGYIPEPVTVSWNSVSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPATNTKVDKP VAKECECKCNCNNCPCP GCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTP GQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSP ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK VK ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK 234 VAKECECKCNCNNCPCPGCGLLGGPSVFIFPPKPKDILVTARTPTVTCVVVDLDPENPEVQISWFVDSKQVQTANTQPREEQSNGTYRVVSVLPIGHQDWLSGKQFKCKVNNKALPSPIEEIISKTPGQAHQPNVYVLPPSRDEMSKNTVTLTCLVKDFFPPEIDVEWQSNGQQEPESKYRMTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQISLSHSP ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSQSGSTVALACLVS Canine membrane BCR IgG-C. IGH: Cgamma-C Canis familiaris immunoglobulin gamma heavy chain C mRNA, membrane spliced form (AF354266). Canis familiaris immunoglobulin gamma heavy chain C mRNA, membrane spliced form (AF354266). Membrane-bound canine IgG-C BCR monomer. VBASE3_C_CANINE_IGHG_D_01 AF354267 https://www.ncbi.nlm.nih.gov/nuccore/AF354267 data/constant_regions/genbank_records/AF354267.gb Canis lupus familiaris Dog IGH Ighg-d 01 Standard IgG-D IgG Secreted 331 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKPVPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKP VPKESTCKCISPCP VPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARG QAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK 234 VPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS N-terminal ASTTAPSVFPLAPSC with PASNTKVDKP and VPKESTCKCISPCP hinge; low effector function. IGH: Cgamma-D Canis familiaris immunoglobulin gamma heavy chain D mRNA, complete cds (AF354267). Canis familiaris immunoglobulin gamma heavy chain D mRNA, complete cds (AF354267). Secreted canine IgG-D heavy chain. Natural low-effector isotype. VBASE3_C_CANINE_IGHG_D_MEM_01 AF354267 https://www.ncbi.nlm.nih.gov/nuccore/AF354267 data/constant_regions/genbank_records/AF354267.gb Canis lupus familiaris Dog IGH Ighg-d 01 Standard IgG-D IgG Membrane 362 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKPVPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSPELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSTVTVPSSRWPSETFTCNVVHPASNTKVDKP VPKESTCKCISPCP VPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARG QAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSP ELDPEEQGWALVTLFLLLLFSVYSTTLTLFK VK ELDPEEQGWALVTLFLLLLFSVYSTTLTLFKVK 232 VPKESTCKCISPCPVPESLGGPSVFIFPPKPKDILRITRTPEITCVVLDLGREDPEVQISWFVDGKEVHTAKTQPREQQFNSTYRVVSVLPIEHQDWLTGKEFKCRVNHIGLPSPIERTISKARGQAHQPSVYVLPPSPKELSSSDTVTLTCLIKDFFPPEIDVEWQSNGQPEPESKYHTTAPQLDEDGSYFLYSKLSVDKSRWQQGDTFTCAVMHEALQNHYTDLSLSHSP ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS Canine membrane BCR IgG-D. IGH: Cgamma-D Canis familiaris immunoglobulin gamma heavy chain D mRNA, membrane spliced form (AF354267). Canis familiaris immunoglobulin gamma heavy chain D mRNA, membrane spliced form (AF354267). Membrane-bound canine IgG-D BCR monomer. VBASE3_C_CANINE_IGHM_SEC_01 P01874 https://www.ncbi.nlm.nih.gov/nuccore/P01874 data/constant_regions/genbank_records/P01874.gb Canis lupus familiaris Dog IGH Ighm 01 Standard IgM IgM Secreted 450 GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPVMLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGKPTLYNVSLVLSDTAGTCY GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPV MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSD QPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPK GVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG KPTLYNVSLVLSDTAGTCY 346 MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGKPTLYNVSLVLSDTAGTCY GSASAPSIFPLVSCE GSASAPSIFPLVSCENSNPTSTVAMGCLAR N-terminal GSASAPSIFPLVSCE distinguishes IgM from all other canine isotypes; tailpiece contains Cys for J-chain. IGH: 1/8 (Cmu) Canis lupus familiaris immunoglobulin mu heavy chain constant region protein (P01874). Canis lupus familiaris immunoglobulin mu heavy chain constant region protein (P01874). Secreted pentameric/hexameric canine IgM backbone. VBASE3_C_CANINE_IGHM_MEM_01 P01874 https://www.ncbi.nlm.nih.gov/nuccore/P01874 data/constant_regions/genbank_records/P01874.gb Canis lupus familiaris Dog IGH Ighm 01 Standard IgM IgM Membrane 472 GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPVMLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTGEGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK GSASAPSIFPLVSCENSNPTSTVAMGCLARDFLPGSITFSWKYENLSAINSTRGFPSVLRGGKYVATSQVFLPSVDIIQGTDEHIVCKVRHSNGNKQKNVPLPV MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSD QPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPK GVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG EGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK VK EGEVSAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFKVK 327 MLTLPPEVSGFIPPRDAFFGNPRKSQLICQASGFSPRQVWSLRDGKQIESGVTTNEVNAEAKNSGPTTYKVTSMLTIQEDAWLSQSVFTCKVEHRGLTFQQNASSMCTSDQPVGISIFTIPPSFASIFNTKSAKLSCLVTDLATYDSVTISWTREENGALKTHTNISESHPNGTFSAMGEATVCVEEWESGEQFTCTVTHVDLPSVLKQTISRPKGVAVHMPSVYVLPPSREQLDLRESATLSCLVTGYSPPDVFVQWVQKGQPVPPDSYVTSAPMPEPQAPGLYFAHSILTVSDEEWNAGETYTCVVAHESLPNRVTERSVDKSTG GSASAPSIFPLVSCE GSASAPSIFPLVSCENSNPTSTVAMGCLAR Canine membrane BCR IgM monomer; short KVK cytoplasmic signaling tail. IGH: 1/8 (Cmu) Canis lupus familiaris immunoglobulin mu heavy chain membrane BCR form (P01874 / AAEX03006126). Canis lupus familiaris immunoglobulin mu heavy chain membrane BCR form (P01874 / AAEX03006126). Membrane-bound canine IgM BCR monomer. VBASE3_C_CANINE_IGHA_SEC_01 L36871 https://www.ncbi.nlm.nih.gov/nuccore/L36871 data/constant_regions/genbank_records/L36871.gb Canis lupus familiaris Dog IGH Igha 01 Standard IgA IgA Secreted 343 SKTSPSVFPLSLCHQESEGYVVIGCLVQGFFPPEPVNVTWNAGKDSTSVKNFPPMKAATGSLYTMSSQLTLPAAQCPDDSSVKCQVQHASSPSKAVSVPCKDNSHPCHPCPSCNEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTEHIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLAGKPTHVNVSVVMAEVDGICY SKTSPSVFPLSLCHQESEGYVVIGCLVQGFFPPEPVNVTWNAGKDSTSVKNFPPMKAATGSLYTMSSQLTLPAAQCPDDSSVKCQVQHASSPSKAVSVPCKD NSHPCHPCPSC NEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTE HIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLA GKPTHVNVSVVMAEVDGICY 241 NSHPCHPCPSCNEPRLSLQKPALEDLLLGSNASLTCTLSGLKDPKGATFTWNPSKGKEPIQKNPERDSCGCYSVSSVLPGCADPWNHGDTFSCTATHPESKSPITVSITKTTEHIPPQVHLLPPPSEELALNELVTLTCLVRGFKPKDVLVRWLQGTQELPQEKYLTWEPLKEPDQTNMFAVTSMLRVTAEDWKQGEKFSCMVGHEALPMSFTQKTIDRLAGKPTHVNVSVVMAEVDGICY SKTSPSVFPLSLCHQ SKTSPSVFPLSLCHQESEGYVVIGCLVQGF N-terminal SKTSPSVFPLSLCHQ; secretory IgA tailpiece with penultimate Cys for J-chain binding. IGH: 8/8 (Calpha) Canis familiaris IgA heavy chain constant region gene, partial cds (L36871). Canis familiaris IgA heavy chain constant region gene, partial cds (L36871). Secreted dimeric canine IgA heavy chain. VBASE3_C_CANINE_IGHE_SEC_01 L36872 https://www.ncbi.nlm.nih.gov/nuccore/L36872 data/constant_regions/genbank_records/L36872.gb Canis lupus familiaris Dog IGH Ighe 01 Standard IgE IgE Secreted 426 TSQDLSVFPLASCCKDNIASTSVTLGCLVTGYLPMSTTVTWDTGSLNKNVTTFPTTFHETYGLHSIVSQVTASGKWAKQRFTCSVAHAESTAINKTFSACALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSESDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPGKRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK TSQDLSVFPLASCCKDNIASTSVTLGCLVTGYLPMSTTVTWDTGSLNKNVTTFPTTFHETYGLHSIVSQVTASGKWAKQRFTCSVAHAESTAINKTFSA CALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSE SDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPG KRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK 327 CALNFIPPTVKLFHSSCNPVGDTHTTIQLLCLISGYVPGDMEVIWLVDGQKATNIFPYTAPGTKEGNVTSTHSELNITQGEWVSQKTYTCQVTYQGFTFKDEARKCSESDPRGVTSYLSPPSPLDLYVHKAPKITCLVVDLATMEGMNLTWYRESKEPVNPGPLNKKDHFNGTITVTSTLPVNTNDWIEGETYYCRVTHPHLPKDIVRSIAKAPGKRAPPDVYLFLPPEEEQGTKDRVTLTCLIQNFFPADISVQWLRNDSPIQTDQYTTTGPHKVSGSRPAFFIFSRLEVSRVDWEQKNKFTCQVVHEALSGSRILQKWVSKTPGK TSQDLSVFPLASCCK TSQDLSVFPLASCCKDNIASTSVTLGCLVT N-terminal TSQDLSVFPLASCCK; four constant domains (CH1-CH4) without independent hinge. IGH: 7/8 (Cepsilon) Canis familiaris IgE heavy chain constant region gene, partial cds (L36872). Canis familiaris IgE heavy chain constant region gene, partial cds (L36872). Secreted canine IgE heavy chain. High affinity for canine Fc-epsilon-RI; key mediator in canine atopic dermatitis. VBASE3_C_CANINE_IGKC_01 BK066061 https://www.ncbi.nlm.nih.gov/nuccore/BK066061 data/constant_regions/genbank_records/BK066061.gb Canis lupus familiaris Dog IGK Igkc 01 Standard (Boxer / Bernese) IgK Kappa Secreted 110 RNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD 0 RNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD RNDAQPAVYLFQPSP RNDAQPAVYLFQPSPDQLHTGSASVVCLLN N-terminal RNDAQPAVYLFQPSP; minority canine light chain (~10% of canine antibodies). IGK: 1/1 (Ckappa) TPA: Canis lupus familiaris IGKC*01 gene for immunoglobulin kappa light chain (BK066061). TPA: Canis lupus familiaris IGKC*01 gene for immunoglobulin kappa light chain (BK066061). Secreted canine kappa light chain constant region. VBASE3_C_CANINE_IGLC1_01 NC_051830 https://www.ncbi.nlm.nih.gov/nuccore/NC_051830 data/constant_regions/genbank_records/NC_051830.gb Canis lupus familiaris Dog IGL Iglc1 01 Standard IgL1 Lambda Secreted 106 GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS 0 GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS GQPKASPSVTLFPPS GQPKASPSVTLFPPSSEELGANKATLVCLI N-terminal GQPKASPSVTLFPPS; predominant light chain in canine antibodies (~90% Lambda). IGL: Tandem Cassette 1 (J1-C1) Canis lupus familiaris chromosome 26, IGLC1 constant region (NC_051830 / IMGT000003). Canis lupus familiaris chromosome 26, IGLC1 constant region (NC_051830 / IMGT000003). Dominant canine lambda constant cassette. Standard light chain backbone for caninized therapeutic mAbs (Lokivetmab, Librela). VBASE3_C_CANINE_IGLC2_01 NC_051830 https://www.ncbi.nlm.nih.gov/nuccore/NC_051830 data/constant_regions/genbank_records/NC_051830.gb Canis lupus familiaris Dog IGL Iglc2 01 Standard IgL2 Lambda Secreted 106 GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS 0 GQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS GQPKASPSVTLFPPS GQPKASPSVTLFPPSSEELGANKATLVCLI N-terminal GQPKASPSVTLFPPS with Val47 variant (SPVTQG); functional lambda cassette. IGL: Tandem Cassette 2 (J2-C2) Canis lupus familiaris chromosome 26, IGLC2 constant region (NC_051830 / IMGT000003). Canis lupus familiaris chromosome 26, IGLC2 constant region (NC_051830 / IMGT000003). Canine lambda constant region allele with Val47. VBASE3_C_CANINE_TRAC_01 BK065026 https://www.ncbi.nlm.nih.gov/nuccore/BK065026 data/constant_regions/genbank_records/BK065026.gb Canis lupus familiaris Dog TRA Trac 01 Standard TRAC TCR Membrane 133 VQDPDPSVYQMRSPKTGRTVCLFTDFDSQADFQKPEGATVISLNSTVLDMKVMDSKSNGALTWNSETNIECKENFQQPFYPSSNYSCDAKLIEKSFETDMDLNFYNLLVIGLRILLLKVIGFNLFMTLRLWSC 0 VQDPDPSVYQMRSPKTGRTVCLFTDFDSQADFQKPEGATVISLNSTVLDMKVMDSKSNGALTWNSETNIECKENFQQPFYPSSNYSCDAKLIEKSFETDMDLNFYNLLVIGLRILLLKVIGFNLFMTLRLWSC VQDPDPSVYQMRSPK VQDPDPSVYQMRSPKTGRTVCLFTDFDSQA N-terminal VQDPDPSVYQMRSPK; pairs with TRBC beta chain in canine alpha/beta TCR. TRA: 1/1 (Calpha) TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRAC gene (BK065026). TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRAC gene (BK065026). Canine TCR alpha constant domain. VBASE3_C_CANINE_TRBC1_01 PV684572 https://www.ncbi.nlm.nih.gov/nuccore/PV684572 data/constant_regions/genbank_records/PV684572.gb Canis lupus familiaris Dog TRB Trbc1 01 Standard TRBC1 TCR Membrane 178 AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSVLVLMAKVKRKGS 0 AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSVLVLMAKVKRKGS AEDLQKVTPPTVTVF AEDLQKVTPPTVTVFEPSEAEISRTQKATL N-terminal AEDLQKVTPPTVTVF; distinguished from TRBC2 by Val168 in transmembrane domain. TRB: Tandem Cassette 1 (Dbeta1-Jbeta1-Cbeta1) Canis lupus familiaris T cell receptor beta constant region 1 (TRBC1) mRNA, partial cds (PV684572). Canis lupus familiaris T cell receptor beta constant region 1 (TRBC1) mRNA, partial cds (PV684572). Canine TCR beta constant domain 1. VBASE3_C_CANINE_TRBC2_01 PV684573 https://www.ncbi.nlm.nih.gov/nuccore/PV684573 data/constant_regions/genbank_records/PV684573.gb Canis lupus familiaris Dog TRB Trbc2 01 Standard TRBC2 TCR Membrane 178 AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSILVLMAKVKRKGS 0 AEDLQKVTPPTVTVFEPSEAEISRTQKATLVCLATGFYPDHVELSWWVNGKEVTSGFSTDPQPYKERPSENDSSYCLSSRLRVSASFWHNPRNHFRCQVQFYGLGDDDEWKYDRVKPITQNISAEAWGRADCGFTSVSYHQGVLSATILYEILLGKATLYAVLVSILVLMAKVKRKGS AEDLQKVTPPTVTVF AEDLQKVTPPTVTVFEPSEAEISRTQKATL N-terminal AEDLQKVTPPTVTVF; distinguished from TRBC1 by Ile168 in transmembrane domain. TRB: Tandem Cassette 2 (Dbeta2-Jbeta2-Cbeta2) Canis lupus familiaris T cell receptor beta constant region 2 (TRBC2) mRNA, partial cds (PV684573). Canis lupus familiaris T cell receptor beta constant region 2 (TRBC2) mRNA, partial cds (PV684573). Canine TCR beta constant domain 2. VBASE3_C_CANINE_TRDC_01 BK065026 https://www.ncbi.nlm.nih.gov/nuccore/BK065026 data/constant_regions/genbank_records/BK065026.gb Canis lupus familiaris Dog TRD Trdc 01 Standard TRDC TCR Membrane 157 SQLPAKPSVFTMRNGTAVACLVKDFYPKAINIRLESSKKLEEYDTAIAISPSGKYSAVKLGRYADPNSVTCSVEHNNEIVHSTDFEPKKKPSGNTKPTEPANVEQMSESFYAPKVHHSSEFTTGTVNMLSLTVLGLRMVFAKSLAINFVLTAKLFFF 0 SQLPAKPSVFTMRNGTAVACLVKDFYPKAINIRLESSKKLEEYDTAIAISPSGKYSAVKLGRYADPNSVTCSVEHNNEIVHSTDFEPKKKPSGNTKPTEPANVEQMSESFYAPKVHHSSEFTTGTVNMLSLTVLGLRMVFAKSLAINFVLTAKLFFF SQLPAKPSVFTMRNG SQLPAKPSVFTMRNGTAVACLVKDFYPKAI N-terminal SQLPAKPSVFTMRNG; pairs with TRGC gamma chain in canine gamma/delta TCR. TRD: 1/1 (Cdelta) TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRDC gene (BK065026). TPA: Canis lupus familiaris breed boxer TRA/TRD locus, TRDC gene (BK065026). Canine TCR delta constant domain. VBASE3_C_RABBIT_IGHG_01 X51647 https://www.ncbi.nlm.nih.gov/nuccore/X51647 data/constant_regions/genbank_records/X51647.gb Oryctolagus cuniculus Rabbit IGH IGHG 01 Native IgG IgG Secreted 324 GQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKPTCPPPELLGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK GQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTV APSTCSKPTCPPPEL LGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARG QPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK 229 APSTCSKPTCPPPELLGGPSSVFLFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK GQPKAPSVFPLAPCC GQPKAPSVFPLAPCCGDTPSSTVTLGCLVK N-terminal GQPKAPSVFPLAPCC. IGH: Cgamma O.cuniculus gene for C alpha1 IgA heavy chain constant region. O.cuniculus gene for C alpha1 IgA heavy chain constant region. Standard rabbit IgG backbone. Widely used for ultra-high affinity research and diagnostic mAbs. VBASE3_C_LLAMA_IGHG1_01 AF246473 https://www.ncbi.nlm.nih.gov/nuccore/AF246473 data/constant_regions/genbank_records/AF246473.gb Lama glama Llama IGH IGHG1 01 Classical IgG1 IgG Secreted 350 ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSQTFTCNVAHPASKTKVDKPVEPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK ASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSQTFTCNVAHPASKTKVDKPV EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCP APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK 252 EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGSTSGSTVALACLVS Conventional heavy chain with full CH1; pairs with light chains. IGH: Cgamma1 Lama glama immunoglobulin gamma-1 heavy chain constant region gene. Lama glama immunoglobulin gamma-1 heavy chain constant region gene. Conventional heavy chain with full CH1. Pairs with light chains. VBASE3_C_LLAMA_IGHG2_01 AF246474 https://www.ncbi.nlm.nih.gov/nuccore/AF246474 data/constant_regions/genbank_records/AF246474.gb Lama glama Llama IGH IGHG2 01 HCAb-LongHinge IgG2 HCAb Secreted 252 EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCP APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK 252 EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK EPKIPQPQPKPQPQP EPKIPQPQPKPQPQPQPQPKPQPKPEPECT Lacks CH1 domain; long 35-aa hinge directly connects VHH domain to CH2. IGH: Cgamma2 Lama glama immunoglobulin gamma-2 heavy chain constant region (HCAb, lacks CH1). Lama glama immunoglobulin gamma-2 heavy chain constant region (HCAb, lacks CH1). Autonomous Heavy-Chain-Only (HCAb) antibody. Splice site mutation causes direct splicing from VHH to long hinge. VBASE3_C_LLAMA_IGHG3_01 AF246475 https://www.ncbi.nlm.nih.gov/nuccore/AF246475 data/constant_regions/genbank_records/AF246475.gb Lama glama Llama IGH IGHG3 01 HCAb-ShortHinge IgG3 HCAb Secreted 228 EPKTPKPQPCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK EPKTPKPQPCP APELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAK GQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK 228 EPKTPKPQPCPAPELLGGPSVFIFPPKPKDVLSISPKPEVTCVVVDVGHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWLNGKEYKCKVSNKGLPAPIEKTISKAKGQPREPQVYTLPPSRDELSKNKVTLTCLIKGFYPSDIAVEWESNGQPVANYKTTPPVLDSDGSYFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSHSPGK EPKTPKPQPCPAPEL EPKTPKPQPCPAPELLGGPSVFIFPPKPKD Lacks CH1 domain; short 11-aa hinge (EPKTPKPQPCP) connects VHH to CH2. IGH: Cgamma3 Lama glama immunoglobulin gamma-3 heavy chain constant region (HCAb, lacks CH1). Lama glama immunoglobulin gamma-3 heavy chain constant region (HCAb, lacks CH1). Short 11-residue hinge HCAb. Directly connects VHH nanobody domain to Fc. VBASE3_C_BOVINE_IGHG1_01 X16701 https://www.ncbi.nlm.nih.gov/nuccore/X16701 data/constant_regions/genbank_records/X16701.gb Bos taurus Cattle IGH IGHG1 01 Native IgG1 IgG Secreted 325 ASTTAPKVYPLSSCCGDKSSSTVTLGCLVSSYMPEPVTVTWNSGALKSGVHTFPAVLQSGLYSLSSMVTVPSSSWLSQTVTCSVAHPASSTTVDKTVPPCPCPPCPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAKGQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK ASTTAPKVYPLSSCCGDKSSSTVTLGCLVSSYMPEPVTVTWNSGALKSGVHTFPAVLQSGLYSLSSMVTVPSSSWLSQTVTCSVAHPASSTTVDKTV PPCPCPP CPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAK GQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK 228 PPCPCPPCPAPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQENPDVKFNWYVDGVEVHKAQTKPREEQFNSTFRVVSVLPIQHQDWLRGKEFKCKVNNKALPAPIEKTISKAKGQPLEPQVYTLAPPQEELSKSKVSLTCLVTGFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDVFTCAVMHETLQNHYTQKSLSHSPGK ASTTAPKVYPLSSCC ASTTAPKVYPLSSCCGDKSSSTVTLGCLVS N-terminal ASTTAPKVYPLSSCC; pairs with bovine ultralong CDR-H3 antibodies. IGH: Cgamma1 Bovine Ig germline heavy chain gamma-1-chain gene C-region, 3' end. Bovine Ig germline heavy chain gamma-1-chain gene C-region, 3' end. Bovine IgG1 heavy chain constant region. Naturally pairs with bovine ultralong CDR-H3 antibodies. VBASE3_C_FELINE_IGHG1A_01 AB016710 https://www.ncbi.nlm.nih.gov/nuccore/AB016710 data/constant_regions/genbank_records/AB016710.gb Felis catus Domestic cat IGH IGHG1A 01 IgG1a IgG1 IgG Secreted 335 ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV RKTDHPPGPKPCDCPKCP PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAK GQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK 237 RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGTTSGATVALACLVL N-terminal ASTTAPSVFPLAPSC with Pro at pos 6 (vs Ser in IgG2); Hinge RKTDHPPGPKPCDCPKCP (18 aa). IGH: 3/6 (Cgamma1a) Felis catus mRNA for IgG1 heavy chain, partial cds (AB016710, Kanai et al. 2000). Felis catus mRNA for IgG1 heavy chain, partial cds (AB016710, Kanai et al. 2000). Primary feline IgG1 subclass backbone used in recombinant therapeutics including Frunevetmab (Solensia, Zoetis) for feline arthritis pain. VBASE3_C_FELINE_IGHG1A_01_MBR BK083199 https://www.ncbi.nlm.nih.gov/nuccore/BK083199 data/constant_regions/genbank_records/BK083199.gb Felis catus Domestic cat IGH IGHG1A 01 IgG1a-BCR IgG1 IgG Membrane 404 ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQGA ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV RKTDHPPGPKPCDCPKCP PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAK GQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFK VKWIFSSVVELKRTIVPDYRNMIGQGA ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQGA 235 RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGTTSGATVALACLVL Membrane BCR: 44-aa extracellular/transmembrane M1 stalk + 27-aa cytoplasmic signaling M2 tail. IGH: 3/6 (Cgamma1a-M) Felis catus isolate OcraZ1 IGH locus, IGHG1A membrane BCR form (BK083199 / AB016710). Felis catus isolate OcraZ1 IGH locus, IGHG1A membrane BCR form (BK083199 / AB016710). Membrane-bound feline BCR IgG1a isoform expressed on memory B-cells. VBASE3_C_FELINE_IGHG1B_01 AB016711 https://www.ncbi.nlm.nih.gov/nuccore/AB016711 data/constant_regions/genbank_records/AB016711.gb Felis catus Domestic cat IGH IGHG1B 01 IgG1b IgG1 IgG Secreted 335 ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDKGQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTV RKTDHPPGPKPCDCPKCP PPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDK GQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK 237 RKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKDKGQPHEPQVYVLPPAQEELSRNKVSVTCLIEGFYPSDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFLYSRLSVDRSRWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTAPSVFPLAPSC ASTTAPSVFPLAPSCGTTSGATVALACLVL N-terminal ASTTAPSVFPLAPSC; Allelic variant b differs by 8 residues in CH2/CH3 from allele a. IGH: 3/6 (Cgamma1b) Felis catus mRNA for IgG1 heavy chain, allele-b (AB016711, Kanai et al. 2000). Felis catus mRNA for IgG1 heavy chain, allele-b (AB016711, Kanai et al. 2000). Feline IgG1b allelic variant (Kanai et al. 2000). VBASE3_C_FELINE_IGHG2_01 KF811175 https://www.ncbi.nlm.nih.gov/nuccore/KF811175 data/constant_regions/genbank_records/KF811175.gb Felis catus Domestic cat IGH IGHG2 01 IgG2 IgG2 IgG Secreted 335 ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTVPKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTV PKTASTIESKTGEGPKCP VPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAK GQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK 237 PKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK ASTTASSVFPLAPSC ASTTASSVFPLAPSCGTTSGATVALACLVL N-terminal ASTTASSVFPLAPSC with Ser at pos 6 (vs Pro in IgG1); Hinge PKTASTIESKTGEGPKCP (18 aa). IGH: 4/6 (Cgamma2) Felis catus immunoglobulin G2 heavy chain constant region mRNA (KF811175, Strietzel et al. 2014, Zoetis). Felis catus immunoglobulin G2 heavy chain constant region mRNA (KF811175, Strietzel et al. 2014, Zoetis). Feline IgG2 constant region characterised by Strietzel et al. 2014 (Zoetis). Intermediate/distinct effector profile. VBASE3_C_FELINE_IGHG2_01_MBR BK083199 https://www.ncbi.nlm.nih.gov/nuccore/BK083199 data/constant_regions/genbank_records/BK083199.gb Felis catus Domestic cat IGH IGHG2 01 IgG2-BCR IgG2 IgG Membrane 404 ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTVPKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQAA ASTTASSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPSVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHRPSSTKVDKTV PKTASTIESKTGEGPKCP VPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAK GQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFK VKWIFSSVVELKRTIVPDYRNMIGQAA ELLLDDSCAEDQDGELDGLWTTISIFITLFLLSVCYSATVTLFKVKWIFSSVVELKRTIVPDYRNMIGQAA 235 PKTASTIESKTGEGPKCPVPEIPGAPSVFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSNVQITWFVDNTEMHTAKTRPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSAMERTISKAKGQPHEPQVYVLPPTQEELSENKVSVTCLIKGFHPPDIAVEWEITGQPEPENNYQTTPPQLDSDGTYFLYSRLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSP ASTTASSVFPLAPSC ASTTASSVFPLAPSCGTTSGATVALACLVL Membrane BCR: 44-aa M1 stalk + 27-aa cytoplasmic M2 tail ending in GQAA. IGH: 4/6 (Cgamma2-M) Felis catus isolate OcraZ1 IGH locus, IGHG2 membrane BCR form (BK083199 / KF811175). Felis catus isolate OcraZ1 IGH locus, IGHG2 membrane BCR form (BK083199 / KF811175). Membrane-bound feline BCR IgG2 isoform. VBASE3_C_FELINE_IGHM_01 BK083199 https://www.ncbi.nlm.nih.gov/nuccore/BK083199 data/constant_regions/genbank_records/BK083199.gb Felis catus Domestic cat IGH IGHM 01 Native IgM IgM Secreted 454 TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPVPVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTGKPTLYNVSLVLSDTATTCY TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPV PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACIL NTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPK DVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST GKPTLYNVSLVLSDTATTCY 348 PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTGKPTLYNVSLVLSDTATTCY TSSRPNLFPLITCES TSSRPNLFPLITCESSLSDEPLVAMGCLAR N-terminal TSSRPNLFPLITCES; Secretory tailpiece GKPTLYNVSLVLSDTATTCY (20 aa). IGH: 1/6 (Cmu) Felis catus isolate OcraZ1 IGH locus, IGHM gene secreted form (BK083199 / D89025). Felis catus isolate OcraZ1 IGH locus, IGHM gene secreted form (BK083199 / D89025). Feline IgM secreted heavy chain (454 aa, CH1-CH4 + tailpiece). VBASE3_C_FELINE_IGHM_01_MBR BK083199 https://www.ncbi.nlm.nih.gov/nuccore/BK083199 data/constant_regions/genbank_records/BK083199.gb Felis catus Domestic cat IGH IGHM 01 Native-BCR IgM IgM Membrane 475 TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPVPVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKSTEGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFKVK TSSRPNLFPLITCESSLSDEPLVAMGCLARDFLPSSVTFSWNYKNNSVVNNQDIQTFPPVLREGKYVATSQVLLPSVDVLQGSDDFLTCNVKHPKGNSEVNVPIPV PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACIL NTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPK DVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST EGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFK VK EGEVSAEEEGFENLNTMASTFIVLFLLSVFYSTTVTLFKVK 328 PVELSPNVTVFIPPRDAFSDNNQRTSQLLCQATGFSPKKISVSWLRDGKPIKSGFNPGNVEAENQGPGPVTYRVLSTLTITENAWLSQSVFTCNVEHSGLTFKKNVSSACILNTQASIRIFAIPPTFASIFQTKSAKLSCRVVDLTTRDSLNISWTRQNGDFLPTTTIFQSNLNNTFSATGEASVCAEDWESGEDFTCTVTHTDLPSPLKKTISKPKDVNKQPPSVYVLPPSREQLSLRESATVTCLVKGFSPADVFVQWLQKGQPMSSESYVTSDPKPEPQDPHLYFVHSTLTVSEEEWSSGETYTCVVGHEALPHMVTERSVDKST TSSRPNLFPLITCES TSSRPNLFPLITCESSLSDEPLVAMGCLAR Membrane BCR: Spliced after CH4 to 39-aa transmembrane M1 + 2-aa cytoplasmic tail VK. IGH: 1/6 (Cmu-M) Felis catus isolate OcraZ1 IGH locus, IGHM membrane BCR form (BK083199). Felis catus isolate OcraZ1 IGH locus, IGHM membrane BCR form (BK083199). Feline membrane-bound naive B-cell receptor (BCR) IgM isoform (475 aa). VBASE3_C_FELINE_IGHA_01 KY795050 https://www.ncbi.nlm.nih.gov/nuccore/KY795050 data/constant_regions/genbank_records/KY795050.gb Felis catus Domestic cat IGH IGHA 01 Native IgA IgA Secreted 344 ESKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVEHYSSTSPAVSVPCRADPPPPCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMSDVEGVCY ESKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVEHYSSTSPAVSVP CRADPPPPCSPCNE PRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVL ENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRL AGKPTHVNVSVVMSDVEGVCY 244 CRADPPPPCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGKKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNGLVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMSDVEGVCY ESKTSPRVFPLSLRT ESKTSPRVFPLSLRTSDPAGQVVIACLVQG N-terminal ESKTSPRVFPLSLRT; Hinge CRADPPPPCSPCNE (14 aa); Tailpiece AGKPTHVNVSVVMSDVEGVCY (21 aa). IGH: 6/6 (Calpha) Felis catus clone cat 2-IGHA-12 IgA constant region mRNA (KY795050, Lu et al. 2017). Felis catus clone cat 2-IGHA-12 IgA constant region mRNA (KY795050, Lu et al. 2017). Feline mucosal IgA heavy chain constant region (335 aa, Lu et al. 2017). VBASE3_C_FELINE_IGHA_01_MBR BK083199 https://www.ncbi.nlm.nih.gov/nuccore/BK083199 data/constant_regions/genbank_records/BK083199.gb Felis catus Domestic cat IGH IGHA 01 Native-BCR IgA IgA Membrane 394 SKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVQHYSSTSPAVSVPCRADPPPQCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLADSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTSVRGPADSREGPQY SKTSPRVFPLSLRTSDPAGQVVIACLVQGFFPPEPVRVTWSPSKEGASIRNFPVVKSASGNLYTTSSQLTLPASQCPDGTSLQCQVQHYSSTSPAVSVPCRA DPPPQCSPCNE PRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVL ENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLA DSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTS VRGPADSREGPQY DSQCLADRREPLPWLVLDLPQEDLEEDAPGASLWPTTVTLLTLFLLSLFYSTALTVTSVRGPADSREGPQY 221 DPPPQCSPCNEPRLSLHKPALEDLLLGSNASITCTLSGLKNPEGALFSWTPSGRKEAIQKPPERDSCGCYSVSSVLPGCAEPWNRGENFSCTASHPELKTPKTDTISKVLENTFRPQVHLLPPPSEELALNELVSLTCLVRGFSPKDVLVRWLQGSQELSREKYLTWGPLQEPDQSVPTFATTSVLRVSAEDWKQGEKFSCMVGHEALPLAFTQKTIDRLA SKTSPRVFPLSLRTS SKTSPRVFPLSLRTSDPAGQVVIACLVQGF Membrane BCR: Spliced after CH3 to 59-aa transmembrane M1 + 13-aa cytoplasmic tail VRGPADSREGPQY. IGH: 6/6 (Calpha-M) Felis catus isolate OcraZ1 IGH locus, IGHA membrane BCR form (BK083199 / KY795050). Felis catus isolate OcraZ1 IGH locus, IGHA membrane BCR form (BK083199 / KY795050). Feline membrane-bound IgA BCR isoform (394 aa). VBASE3_C_FELINE_IGKC_01 AF198257 https://www.ncbi.nlm.nih.gov/nuccore/AF198257 data/constant_regions/genbank_records/AF198257.gb Felis catus Domestic cat IGK IGKC 01 Native IgK Kappa Secreted 110 RSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE 0 RSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE RSDAQPSVFLFQPSL RSDAQPSVFLFQPSLDELHTGSASIVCILN N-terminal RSDAQPSVFLFQPSL; diagnostic RSDAQPS motif distinguishes cat kappa from dog (RNDAQPA) and human (RTVAAPS). IGK: 1/1 (Ckappa) Felis catus immunoglobulin kappa light chain mRNA, complete cds (AF198257, Heska Corp). Felis catus immunoglobulin kappa light chain mRNA, complete cds (AF198257, Heska Corp). Feline kappa light chain constant region (107 aa). Natural light chain for Frunevetmab (Solensia). VBASE3_C_FELINE_IGLC1_01 KY795178 https://www.ncbi.nlm.nih.gov/nuccore/KY795178 data/constant_regions/genbank_records/KY795178.gb Felis catus Domestic cat IGL IGLC1 01 Native IgL1 Lambda Secreted 106 GQPKSAPSVTLFPPSSEELSANKATLVCLISDFYPSGLTVAWKADGTPVTQGVETTKPSKQSNNKYAASSYLSLSPNEWKSHSRFTCQVTHEGSTVEKSVVPAECS 0 GQPKSAPSVTLFPPSSEELSANKATLVCLISDFYPSGLTVAWKADGTPVTQGVETTKPSKQSNNKYAASSYLSLSPNEWKSHSRFTCQVTHEGSTVEKSVVPAECS GQPKSAPSVTLFPPS GQPKSAPSVTLFPPSSEELSANKATLVCLI N-terminal GQPKSAPSVTLFPPS with Ser at pos 6 (vs Ala in canine GQPKASPS and human GQPKAAPS). IGL: 1/11 (Clambda1) Felis catus clone cat 2-IGLC-1 IgG lambda chain constant region (KY795178 / KY795194, Lu et al. 2017). Felis catus clone cat 2-IGLC-1 IgG lambda chain constant region (KY795178 / KY795194, Lu et al. 2017). Feline lambda light chain constant region (106 aa). Cat repertoires are ~60-80% lambda dominant. VBASE3_C_FELINE_TRAC_01 D89022 https://www.ncbi.nlm.nih.gov/nuccore/D89022 data/constant_regions/genbank_records/D89022.gb Felis catus Domestic cat TRA TRAC 01 Native TRAC TCR Secreted 113 TSSKASNPSTISVCLFTDFDSEVNVNPSTESNMIRLKSTSLDMKTMDSKSNWALAWSNSFDLGCNSTFNYTFHSSSEFPCDANVVEKGFETDMNLNFDNLTVIMLRIIFLKAV 0 TSSKASNPSTISVCLFTDFDSEVNVNPSTESNMIRLKSTSLDMKTMDSKSNWALAWSNSFDLGCNSTFNYTFHSSSEFPCDANVVEKGFETDMNLNFDNLTVIMLRIIFLKAV TSSKASNPSTISVCL TSSKASNPSTISVCLFTDFDSEVNVNPSTE N-terminal TSSKASNPSTISVCL; single feline TRAC gene located on chromosome B3. TRA: 1/1 (Calpha) Felis catus mRNA for TCR alpha constant chain, partial cds (D89022, Cho et al. 1998 / Radtanakatikanon 2020). Felis catus mRNA for TCR alpha constant chain, partial cds (D89022, Cho et al. 1998 / Radtanakatikanon 2020). Feline T-cell receptor alpha chain constant domain (113 aa). VBASE3_C_FELINE_TRBC1_01 XM_045052894 https://www.ncbi.nlm.nih.gov/nuccore/XM_045052894 data/constant_regions/genbank_records/XM_045052894.gb Felis catus Domestic cat TRB TRBC1 01 Native TRBC1 TCR Secreted 177 EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGANVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS 0 EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGANVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS EDLKKVSPPKVTVFE EDLKKVSPPKVTVFEPSEAEISRTLKATLV N-terminal EDLKKVSPPKVTVFE; diagnostic Lys5 Lys6 (EDLKK) distinguishes feline TRBC from human (EDLNK/EDLKN) and canine (AEDLQ). TRB: Tandem Cassette 1 Felis catus T cell receptor beta constant region 1 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020). Felis catus T cell receptor beta constant region 1 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020). Feline T-cell receptor beta constant cassette 1 on chromosome A2 (177 aa, Radtanakatikanon et al. 2020). VBASE3_C_FELINE_TRBC2_01 XM_045052894 https://www.ncbi.nlm.nih.gov/nuccore/XM_045052894 data/constant_regions/genbank_records/XM_045052894.gb Felis catus Domestic cat TRB TRBC2 01 Native TRBC2 TCR Secreted 177 EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGASVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS 0 EDLKKVSPPKVTVFEPSEAEISRTLKATLVCLATGFYPDHVELSWWVNGKEVRDGVSTDPEPYKEQSGASVSSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLGKDDQWDYPEAKPVTQNVSADTWGRADCGFTSASYQQGVLSATILYEILLGKATLYAILVSVLALMAKVKRKDS EDLKKVSPPKVTVFE EDLKKVSPPKVTVFEPSEAEISRTLKATLV N-terminal EDLKKVSPPKVTVFE; Ser101 (GASV) distinguishes TRBC2 from Asn101 (GANV) in TRBC1. TRB: Tandem Cassette 2 Felis catus T cell receptor beta constant region 2 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020). Felis catus T cell receptor beta constant region 2 (XM_045052894 / CM001379.3, Radtanakatikanon et al. 2020). Feline T-cell receptor beta constant cassette 2 on chromosome A2 (177 aa). VBASE3_C_FELINE_TRDC_01 D89018 https://www.ncbi.nlm.nih.gov/nuccore/D89018 data/constant_regions/genbank_records/D89018.gb Felis catus Domestic cat TRD TRDC 01 Native TRDC TCR Secreted 125 DFYPKDINIKLEPTKKLEEFDPAIVVSPSGKYSAVKLGRYEDPNSVTCSVEHNSEVVSSTNFEPRTNSSGTVKPKPTESENIKLTPKSISEPKATVRHSSQFTAGNVNMLSLTVLGLRMVFAKSL 0 DFYPKDINIKLEPTKKLEEFDPAIVVSPSGKYSAVKLGRYEDPNSVTCSVEHNSEVVSSTNFEPRTNSSGTVKPKPTESENIKLTPKSISEPKATVRHSSQFTAGNVNMLSLTVLGLRMVFAKSL DFYPKDINIKLEPTK DFYPKDINIKLEPTKKLEEFDPAIVVSPSG N-terminal DFYPKDINIKLEPTK; nested within feline TRA locus on chromosome B3. TRD: 1/1 (Cdelta) Felis catus mRNA for TCR delta constant chain, partial cds (D89018, Cho et al. 1998 / Radtanakatikanon 2020). Felis catus mRNA for TCR delta constant chain, partial cds (D89018, Cho et al. 1998 / Radtanakatikanon 2020). Feline T-cell receptor delta constant domain (125 aa).