Dog (Canis lupus familiaris) Antibody Analyzer

Canine Antibody & Veterinary Biotherapeutic Workbench

Curated database of 29 Class I canine V-genes, benchmark caninized biotherapeutics (Lokivetmab, Bedinvetmab, Gilvetmab), and light chain lambda-dominance profiling.

Class I V-Genes

J-Segments

D-Elements

Benchmark mAbs

📥 Input Dog Antibody Sequence

DNA or Amino Acid

Load Landmark Preset:

📊 Analysis Results

🐕

Enter a Canine nucleotide or amino acid sequence, or click a landmark preset above to begin.

📚 Canine Class I Functional Repertoire Catalog

Sourced from Stratum 3 Master Catalog (Cys104 Anchored)

Gene ID	Locus	Chain	Classification	Mature V-Exon (to Cys104)	RSS / Evidence	Action

🔬 Benchmark Caninized Monoclonal Antibodies

Approved Veterinary Biotherapeutics

Clone / Therapeutic	Clinical Target	V / J Assignment	Boundary	Therapeutic Mechanism & Significance	Action

🏛️ Caninization Engineering & Comparative Immunogenetics

Companion Animal Antibody Architecture

The Veterinary Monoclonal Antibody Revolution:

Companion animal therapeutics has undergone a rapid paradigm shift with the advent of "caninized" monoclonal antibodies. Rather than using small molecules with non-specific organ toxicity, veterinary medicine now utilizes high-affinity caninized antibodies engineered to match the natural canine immunoglobulin architecture.

Key Structural & Immunogenetic Hallmarks in VBASE3:

Inverted Light Chain Partitioning (~90% Lambda Dominance): Whereas humans exhibit ~60% Kappa and mice >95% Kappa, dogs display an inverted repertoire dominated by the Lambda light chain (~90% IGL vs. ~10% IGK). Therapeutic caninization campaigns must account for this structural preference when selecting light chain pairings.
Restricted Heavy Chain Families: The canine heavy chain repertoire is predominantly composed of Clan III-related IGHV genes that exhibit high homology to human IGHV3, greatly simplifying human-to-canine antibody conversion.
Strict IMGT Synthesis Boundaries: Canonical synthesis endpoints (TVSS for heavy, TVL for lambda, and VEIK/LEIK for kappa) ensure zero constant region bleed-through in recombinant veterinary production.
Repertoire-Confirmed Class I Functional Universe: All 29 canine V-genes in this analyzer represent confirmed functional segments with rearranged physiological evidence, trimmed strictly to Cys104.