🧬 IMGT Sequence Alignment Single Sequence 0 genes

🧬 VBASE3 • TCRbase

αβ & γδ TCR

Vertebrate T-Cell Receptor Universe (3,114 Genes • 9 D-Genes • 91 J-Genes) • αβ & γδ Chains across 31 Species • Systematic Clan & Orthogroup Naming
✨ Human-AI Collaborative Experiment: Werner Müller & Google Antigravity (Gemini Models)

🏠 Portal Home 🛡️ BCRbase (Antibodies) 🧬 TCRbase (TCRs)

⚡ Client WASM: Active (In-Browser)

Reference Catalog:

📊 Single-Cell Repertoire ↗ Switch to VBASE3 ↗

3,114Vertebrate TCR Genes

31Vertebrate Species

9 D / 91 JTCR D & J Elements

4 Lociαβ & γδ (TRA/B/G/D)

Hierarchy & Color: Focus Species: 👤 Human TCR Analyzer 🐁 Mouse TCR Analyzer

🔬 TCRbase Sequence Projection Engine

Paste unknown human or mouse T-cell receptor sequence (DNA or Protein). The engine automatically identifies TCR locus (TRA, TRB, TRG, TRD), closest TCRbase germline, and projects the query directly onto the 2D TCR manifold!

VERTEBRATE BENCHMARK SAMPLES:

🟢 Human 1G4 TCRα (PDB 2BNR • NY-ESO-1)

🔵 Human 1G4 TCRβ (PDB 2BNR • NY-ESO-1)

🟠 Murine 2B4 TCRα (PDB 3QIU • Chien 1984)

🟡 Bovine TRDV1 (GenBank AY644517)

🐟 Zebrafish TRAV (GenBank BC164878)

🐔 Chicken TRA (GenBank M30358)

🦈 Nurse Shark NAR-TCR (PNAS 2006)

TCRbase Manifold Coordinates Projected!

(x: 0, y: 0)

Species: - Chain: - Family: - Clan: - 0 SHM

Closest TCRbase V-Gene

Diversity Element (D)

Joining Element (J) & Boundary

Canonical Boundary Verified

Junctional CDR3

-

Length: 0

DOMAIN ARCHITECTURE & JUNCTIONS:

Operation	Client WASM (In-Browser)	Server Native Rust (M4 Pro)	Speedup
Sequence Landmark Detection & Germline Alignment	~18.5 seqs / sec (54 ms)	8,989 queries / sec (0.11 ms)	🚀 485x
All-vs-All Germline Pairwise Comparisons	~38,900 comps / sec	18,905,000 comps / sec	🚀 485x
PaCMAP 2D Projection (100 Seqs)	~13.9 ms (~7,180 seqs/s)	5.3 ms (~18,750 seqs/s)	🚀 2.6x
Execution Architecture	Single-threaded WebAssembly in Web Worker/V8	16-thread Rayon Work-Stealing + NEON SIMD	Hardware-Native